Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system

Mi, Bobin; Xiong, Yuan; Knoedler, Samuel; Alfertshofer, Michael; Panayi, Adriana C.; Wang, Haixing; Lin, Sien; Li, Gang; Liu, Guohui

doi:10.1038/s41413-024-00346-4

Cited by 2 publications

References 186 publications

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Associations Among Estrogens, the Gut Microbiome and Osteoporosis

Kverka,

Stepan

2024

Curr Osteoporos Rep

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Purpose of the Review The purpose of this Review was to summarize the evidence on the associations among estrogen status, cellular senescence, the gut microbiome and osteoporosis. Recent Findings Indicate that osteoporosis is a global public health problem that impacts individuals and society. In postmenopausal women, a decrease in estrogen levels is associated with a decrease in gut microbial diversity and richness, as well as increased permeability of the gut barrier, which allows for low-grade inflammation. The direct effects of estrogen status on the association between bone and the gut microbiome were observed in untreated and treated ovariectomized women. In addition to the direct effects of estrogens on bone remodeling, estrogen therapy could reduce the risk of postmenopausal osteoporosis by preventing increased gut epithelial permeability, bacterial translocation and inflammaging. However, in studies comparing the gut microbiota of older women, there were no changes at the phylum level, suggesting that age-related comorbidities may have a greater impact on changes in the gut microbiota than menopausal status does. Summary Estrogens modify bone health not only by directly influencing bone remodeling, but also indirectly by influencing the gut microbiota, gut barrier function and the resulting changes in immune system reactivity.

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Associations Among Estrogens, the Gut Microbiome and Osteoporosis

Kverka,

Stepan

2024

Curr Osteoporos Rep

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Annotation and assessment of functional variants in regulatory regions using epigenomic data in farm animals

Ma,

Kuang,

Zhang

et al. 2024

Preprint

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Single nucleotide polymorphisms (SNPs) and small insertions/deletions (2-50bp) in genomic regulatory regions may impact function, and although widespread, they are largely unexplored in livestock. Here leveraging >500 epigenomic datasets from pigs, cattle, sheep, and chickens, 8-39 million variants were identified with candidate functional confidence. Using our Functional Confidence scoring system, these candidate functional variants were further ranked as High, Moderate, Low, Minimal, or Possible functional confidence by scoring for likelihood of disrupting transcription factor (TF)-chromatin binding based on their presence in eight genomic regulatory features. Predictive reliability analysis of estimated breeding values (EBVs) based on High/Moderate Confidence variants from pig shows a 23∼46% increase in reliability compared to EBVs based on general SNPs, illustrating the versatility of Functional Confidence scoring system for identifying potential functional variants in livestock. Therefore, we developed the Integrated Functional Mutation (IFmut) platform and embed the Functional Confidence scoring system for users to effortlessly navigate through epigenomic data or pinpoint specific genomic features/regions, uncover potential function of new variants or previously identified ones. Our work offers the scientific community a powerful and flexible tool, tailor-made for delving deep into variant function, setting a new benchmark in livestock research and breeding strategies.

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Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system

Cited by 2 publications

References 186 publications

Associations Among Estrogens, the Gut Microbiome and Osteoporosis

Associations Among Estrogens, the Gut Microbiome and Osteoporosis

Annotation and assessment of functional variants in regulatory regions using epigenomic data in farm animals

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