2024
DOI: 10.3390/molecules29174065
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Agents Targeting the Bacterial Cell Wall as Tools to Combat Gram-Positive Pathogens

Aliaksandr Zhydzetski,
Zuzanna Głowacka-Grzyb,
Michal Bukowski
et al.

Abstract: The cell wall is an indispensable element of bacterial cells and a long-known target of many antibiotics. Penicillin, the first discovered beta-lactam antibiotic inhibiting the synthesis of cell walls, was successfully used to cure many bacterial infections. Unfortunately, pathogens eventually developed resistance to it. This started an arms race, and while novel beta-lactams, either natural or (semi)synthetic, were discovered, soon upon their application, bacteria were developing resistance. Currently, we are… Show more

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