Aggregation-Induced Emission (AIE) has gone through a rapid development since it’s discovery back in 2001. It is a famous research topic as it shows many advantages compared with traditional fluorescent material struggling with the issue of Aggregation-caused quenching (ACQ), since it only emits fluorescence when gathered. AIE material can provide better sensitivity, better photobleaching resistance and SNR compared with traditional material. AIE material can be applied in the fields of biosensing and bioimaging to replace traditional material with a better performance. This article describes the concept and structure of AIE material, shows types of the material with examples, also introduces the application of AIE material in photodynamic therapy, this article talks about the concept, usage, advantages and drawbacks of applying material with AIE characteristics in photodynamic therapy.