Aggregation-induced signal amplification strategy based on peptide self-assembly for ultrasensitive electrochemical detection of melanoma biomarker

Yuan, Liang; Li, Mengfei; Li, Jiaying; Zhu, Tao-Feng; Dong, Mingdong; Liu, Lei

doi:10.1016/j.aca.2024.342214

Cited by 5 publications

(1 citation statement)

References 54 publications

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“…This lack of alteration might suggest that the binding sites, particularly the pyridine nitrogen ends, were inaccessible to the incoming metal ions due to extensive selfassembly in the aqueous medium. [34] In contrast, investigating the interaction of compound 2 with metal ions in the aqueous medium proved challenging as the solution of compound 2 was found to be unstable, precipitating within an hour. Consequently, to circumvent this issue, a neutral surfactant (Brij-58) was employed as a solubilizing agent.…”

Section: Resultsmentioning

confidence: 99%

Tuning Sensing Efficacy of Oligo(phenylenevinylene) Based Chromogenic Probes: Effect of Alkyl Substituents on Metal Ion Detection at Micelle‐Water Interface

Barkale,

Dey

2024

Chemistry An Asian Journal

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In this work, we conducted a comparative analysis of the metal ion sensing capabilities of two pyridine‐end oligo p‐phenylenevinylene compounds featuring different alkyl substituents (‐C4H9 and ‐C16H33) within a micelle medium. Our findings revealed a correlation between the positioning of the probe molecules within the micelle and the length of the alkyl chains, impacting their self‐assembly tendencies and optical characteristics. The compound with shorter alkyl chains demonstrated a superior affinity towards Hg2+ ions, whereas exposure to the compound with longer alkyl substituent resulted in a color‐changing response with both Cu2+and Hg2+ ions. Intriguingly, the sensitivity towards Hg2+ ions heightened with increasing alkyl chain length. This trend persisted in non‐polar solvents like THF. The capacity to modulate sensing efficacy solely by adjusting the length of the alkyl chains represents a relatively uncommon occurrence in the existing literature. This discovery suggests promising prospects for engineering sensory devices equipped with adaptable sensitivity.

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Section: Resultsmentioning

confidence: 99%

Tuning Sensing Efficacy of Oligo(phenylenevinylene) Based Chromogenic Probes: Effect of Alkyl Substituents on Metal Ion Detection at Micelle‐Water Interface

Barkale,

Dey

2024

Chemistry An Asian Journal

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Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes

Campuzano,

Pedrero,

Barderas

et al. 2024

Anal Bioanal Chem

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Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years. Among them, its compromised performance in complex biological matrices due to fouling or receptor stability issues, the limitations in determining toxic and small analytes, and its use, conditioned to the commercial availability of commercial receptors and the exploration of natural molecular interactions, deserved to be highlighted. To address these challenges, in addition to the intrinsic properties of electrochemical biosensing, its coupling with biomimetic materials has played a fundamental role, among which bioinspired phage and peptide probes stand out. The versatility in design and employment of these probes has opened an unimaginable plethora of possibilities for electrochemical biosensing, improving their performance far beyond the development of highly sensitive and selective devices. The state of the art offers robust electroanalytical biotools, capable of operating in complex samples and with exciting opportunities to discover and determine targets regardless of their toxicity and size, the commercial availability of bioreceptors, and prior knowledge of molecular interactions. With all this in mind, this review offers a panoramic, novel, and updated vision of both the tremendous advances and opportunities offered by the combination of electrochemical biosensors with bioinspired phage and peptide probes and the challenges and research efforts that are envisioned in the immediate future. Graphical Abstract

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A Novel Enzyme-Based Electrochemical Biosensor for Sensitive Detection of Hydrogen Peroxide Based on the Fluorescent Peptide Self-Assembled Nanomaterials

Tang,

Li,

et al. 2024

J Inorg Organomet Polym

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Aggregation-induced signal amplification strategy based on peptide self-assembly for ultrasensitive electrochemical detection of melanoma biomarker

Cited by 5 publications

References 54 publications

Tuning Sensing Efficacy of Oligo(phenylenevinylene) Based Chromogenic Probes: Effect of Alkyl Substituents on Metal Ion Detection at Micelle‐Water Interface

Tuning Sensing Efficacy of Oligo(phenylenevinylene) Based Chromogenic Probes: Effect of Alkyl Substituents on Metal Ion Detection at Micelle‐Water Interface

Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes

A Novel Enzyme-Based Electrochemical Biosensor for Sensitive Detection of Hydrogen Peroxide Based on the Fluorescent Peptide Self-Assembled Nanomaterials

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