2021
DOI: 10.1096/fasebj.2021.35.s1.04133
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Aggregation of wild‐type gelsolin peptides and mutants and inhibition

Abstract: Gelsolin amyloidosis is a disease characterized by several point mutations that lead to cleavage and fibrillization of gelsolin. The D187 mutation to N or Y leads to aggregation of peptide fragments with shortest aggregating peptide identified as 182SFNNGDCFILD192. Recently, G167 has also been identified as relevant gelsolin mutation, which leads to gelsolin deposits in kidneys but its aggregation is much less understood. Hence, we systematically investigated in vitro the aggregation propensities of the follow… Show more

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