Aggression After Traumatic Brain Injury: Prevalence and Correlates

Rao, Vani; Rosenberg, Paul B.; Bertrand, Melaine; Salehinia, Saeed; Spiro, Jennifer; Vaishnavi, Sandeep; Rastogi, Pramit; Noll, Kathy; Schretlen, David J.; Brandt, Jason; Cornwell, Edward E.; Makley, Michael; Miles, Quincy Samus

doi:10.1176/appi.neuropsych.21.4.420

Cited by 84 publications

(78 citation statements)

References 34 publications

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“…Prevalence rates for irritability and aggression after traumatic brain injury (TBI) for example range from 29% to 96% (see for example McNett, Sarver, & Wilczewski, 2012;Rao et al, 2009;Sabaz et al, 2014;Visscher, Van Meijel, Stolker, Wiersma, & Nijman, 2011). Scholten et al (2016) in a systematic review found that prevalence rates for depressive disorders after TBI are up to 21% to 57% after follow-up periods of on average 1.5 to 3 years.…”

Section: Introductionmentioning

confidence: 99%

Effects of a behaviour management technique for nursing staff on behavioural problems after acquired brain injury

Winkens

Heugten

Pouwels

et al. 2017

Neuropsychological Rehabilitation

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The ABC method is a behaviour management technique for use by nurses. ABC refers to the identification of Antecedent events, target Behaviours, and Consequent events. In this longitudinal intervention study with double baseline measurements we evaluated the effectiveness of the ABC method in patients with behavioural problems after acquired brain injury. Fifty-six patients participated in this study. Outcome was measured in terms of overall neuropsychiatric problem behaviour, aggression, apathy and emotional burden experienced by nurses. A process evaluation was performed to investigate usability and acceptability of the method and identify factors that influenced effectiveness. Friedman's ANOVA showed a small significant reduction over time in overall neuropsychiatric problem behaviour and aggression. The reduction was most prominent between the first baseline measurement and the post-implementation and follow-up measurements, not between the second baseline measurement and the post-implementation or followup measurements. This first group study on the effects of the ABC method could not prove this technique is effective for patients with behavioural problems after acquired brain injury. Nurses indicated that the ABC method was not fully implemented in their daily routines. This may have influenced results and makes it yet premature to draw firm conclusions on the effects of the ABC method.

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Section: Introductionmentioning

confidence: 99%

Effects of a behaviour management technique for nursing staff on behavioural problems after acquired brain injury

Winkens

Heugten

Pouwels

et al. 2017

Neuropsychological Rehabilitation

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“…Longitudinal studies have shown that aggressive behavior emerges in early childhood with a peak between 2 and 4 years of age, but decreases during childhood in most individuals (Alink et al, 2006;Cote et al, 2006Cote et al, , 2007Tremblay et al, 2004). Abnormal levels of aggression in childhood and adulthood are a characteristic of several psychiatric disorders (Coccaro 2012;Coie et al, 1992;Nestor, 2002) and may be caused by traumatic brain injury (Rao et al, 2009;Tateno et al, 2003), substance abuse (Boles & Miotto, 2003;Moore et al, 2008), and neurodegenerative diseases (Lai et al, 2003;Moechars et al, 1996;Volicer & Hurley, 2003).…”

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confidence: 99%

Epigenome-Wide Association Study of Aggressive Behavior

et al. 2015

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Aggressive behavior is highly heritable, while environmental influences, particularly early in life, are also important. Epigenetic mechanisms, such as DNA methylation, regulate gene expression throughout development and adulthood, and may mediate genetic and environmental effects on complex traits. We performed an epigenome-wide association study (EWAS) to identify regions in the genome where DNA methylation level is associated with aggressive behavior. Subjects took part in longitudinal survey studies from the Netherlands Twin Register (NTR) and participated in the NTR biobank project between 2004 and 2011 (N = 2,029, mean age at blood sampling = 36.4 years, SD = 12.4, females = 69.2%). Aggressive behavior was rated with the ASEBA Adult Self-Report (ASR). DNA methylation was measured in whole blood by the Illumina HM450k array. The association between aggressive behavior and DNA methylation level at 411,169 autosomal sites was tested. Association analyses in the entire cohort showed top sites at cg01792876 (chr8; 116,684,801, nearest gene = TRPS1, p = 7.6 × 10 −7 , False discovery rate (FDR) = 0.18) and cg06092953 (chr18; 77,905,699, nearest gene = PARD6G-AS1, p = 9.0 ×10 −7 , FDR = 0.18). Next, we compared methylation levels in 20 pairs of monozygotic (MZ) twins highly discordant for aggression. Here the top sites were cg21557159 (chr 11; 107,795,699, nearest gene = RAB39, p = 5.7 × 10 −6 , FDR = 0.99), cg08648367 (chr 19; 51,925,472, nearest gene = SIGLEC10, p = 7.6 × 10 −6 , FDR = 0.99), and cg14212412 (chr 6; 105,918,992, nearest gene = PREP, p = 8.0 × 10 −6 , FDR = 0.99). The two top hits based on the entire cohort showed the same direction of effect in discordant MZ pairs (cg01792876, P discordant twins = 0.09 and cg06092953, P discordant twins = 0.24). The other way around, two of the three most significant sites in discordant MZ pairs showed the same direction of effect in the entire cohort (cg08648367, P entire EWAS = 0.59 and cg14212412, P entire EWAS = 3.1 × 10 −3 ). Gene ontology analysis highlighted significant enrichment of various central nervous system categories among higher-ranking methylation sites. Higher-ranking methylation sites also showed enrichment for DNase I hypersensitive sites and promoter regions, showing that DNA methylation in peripheral tissues is likely to be associated with aggressive behavior.

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“…In presented case, in programme A, relative beta training was applied, according to recent findings in the subject literature [26,34], although it proved to be ineffective. The patient's attention did not improve which, generally, is a bad sign for recovery [35][36][37][38][39].…”

Section: Discussionmentioning

confidence: 92%

“…technique that modulates cortical activity [25,26]. During rTMS, a fluctuating magnetic field is used to induce an electrical current discharged through a coil held to the scalp over the brain region of interest.…”

Section: Program B -Administered In 2 Modules: A) Module 3 -Repetitivmentioning

confidence: 99%

“…One of the more exciting aspects of this treatment to emerge is the extension of intervention beyond the clinical setting into real-life social environments to which the patients return to after discharge from acute hospitalization and rehabilitation. However, the results are limited and the functional gains often minimal [17,22,23,24,25,26]. Therefore, adjunct interventions that can augment the response of the brain to the behavioural and cognitive training employed might be useful to enhance therapy-induced recovery in TBI patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Application of ERPs neuromarkers for assessment and treatment of a patient with chronic crossed aphasia after severe TBI and long-term coma – Case Report

Chantsoulis¹,

Półrola²,

Góral-Półrola³

et al. 2017

Ann Agric Environ Med.

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Objective. The study aimed to evaluate the application of ERPs neuromarkers for the assessment and treatment of a patient with chronic crossed aphasia after severe TBI and a long-term coma. Case report. An ambidextrous female patient, aged 29, suffered from posttraumatic chronic crossed aphasia, severe TBI and a prolonged coma after a car accident. The patient took part in two differentiated rehabilitation programmes of neurotherapy included 20 sessions of relative beta training and 20 sessions of rTMS; both programmes were combined with behavioural training. The patient was tested 3 times: before the experiment, after completion of programme A, and after completion of programme B. Results. In the 1 st recording, the neuromarker of aphasia was found -an excess of the P2 wave over the left temporal area. There was a cognitive control deficit -an excess of omission errors and an increase of RT variability -all indexes of sporadic ADHD. In the 2 nd recording, slight improvements in cognitive control, and language functions were found. In the 3 rd recording, after the rTMS sessions most of her cognitive dysfunctions had been resolved, including language functions. It should be stressed that the activation (especially the increase in the ERP potential of the right side over the frontal lobe) was found. The neuromarker of aphasia did not change, only the location had slightly moved frontally. Conclusions. The application of ERP neuromarkers assists in the diagnosis, treatment, and academic success of an ambidextrous patient with chronic posttraumatic aphasia and sporadic ADHD. ERPs can be used to assess the functional brain changes induced by neurotherapeutical programmes.

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Aggression After Traumatic Brain Injury: Prevalence and Correlates

Cited by 84 publications

References 34 publications

Effects of a behaviour management technique for nursing staff on behavioural problems after acquired brain injury

Effects of a behaviour management technique for nursing staff on behavioural problems after acquired brain injury

Epigenome-Wide Association Study of Aggressive Behavior

Application of ERPs neuromarkers for assessment and treatment of a patient with chronic crossed aphasia after severe TBI and long-term coma – Case Report

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