Aggressive Papillary Thyroid Microcarcinoma

Ardito, G; Revelli, Luca; Giustozzi, E.; Salvatori, Massimo; Fadda, Guido; Ardito, Francesco; Avenia, Nicola; Ferretti, Alice; Rampin, Lucia; Chondrogiannis, Sotirios; Colletti, Patrick M.; Rubello, Domenico

doi:10.1097/rlu.0b013e318279bc65

Cited by 86 publications

(47 citation statements)

References 24 publications

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“…Five studies were conducted in the Republic of Korea [16, 17, 21, 22, 24], one in Spain [18], five in Italy [19, 23, 25, 26, 29], one in Taiwan [20], one in United State of American [27], and one in Turkey [28]. Thirteen reports were retrospective studies [19–25, 27–29], and one was prospective study [26].…”

Section: Resultsmentioning

confidence: 99%

“…The fourteen studies showed inconsistent results regarding PTMC recurrence rate between patients with total thyroidectomy and patients with non-total thyroidectomy. 11 out of the 14 studies showed no significant difference of the recurrence rate between two operation groups; two studies showed that the recurrence rates were significantly higher in patients treated with non-total thyroidectomy [19, 25]; only one study showed that the recurrence rate in total thyroidectomy group was significantly higher than that in non-total thyroidectomy group [23]. These fourteen studies assembled 6839 patients in total, 4519 and 2320 were treated with total thyroidectomy and non-total thyroidectomy, respectively.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A meta-analysis on the effect of operation modes on the recurrence of papillary thyroid microcarcinoma

Song

Huang

et al. 2016

Oncotarget

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Whether total thyroidectomy reduces the recurrence rate in patients with papillary thyroid microcarcinoma (PTMC) is currently controversy. Conclusions of sporadic, inconsistent, and mono-institutional studies need a meta-analysis to evaluate. 525 relevant studies were obtained from initial search on PubMed, 511 studies were excluded by inclusion and exclusion criteria. Eligible data were extracted from each included study. The Odds ratios (ORs) and 95% confidence interval (CI) were used to assess the difference in the recurrence rates between PTMC patients treated with total thyroidectomy and non-total thyroidectomy. OR and 95% CI were calculated using a fixed-effects or a random-effects model. The Q statistic was used to evaluate homogeneity and Beggs test was used to assess publication bias. 14 studies meeting the inclusion criteria were included in this meta-analysis. The over all recurrence rates of pooled patients with total thyroidectomy and non-total thyroidectomy were 2.83% and 2.84% respectively. Primary random-effects model analysis showed, no significant difference of recurrence rates existed between two operation modes (OR = 0.732, 95% CI: 0.444 - 1.208), while, high heterogeneity among studies was found, I-squared index (I2) = 40.2%. After remove one study with high heterogeneity, the OR of the pooled recurrence rates of the total thyroidectomy and the non-total thyroidectomy groups was 0.786 (95% CI: 0.363 - 1.701), further suggesting no significant difference of the recurrence rate exists between two operation modes. Our meta-analysis demonstrated postoperative recurrence of PTMC is not reduced by total thyroidectomy, non-total thyroidectomy is also a good choice to treat PTMC patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A meta-analysis on the effect of operation modes on the recurrence of papillary thyroid microcarcinoma

Song

Huang

et al. 2016

Oncotarget

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“…In our multivariate statistical analysis, we identified extrathyroid invasion, solid pattern, tumor multifocality, and absence of a tumor capsule as significant and independent risk factors for PTMC recurrence [25], although less information was available about postoperative 131 I therapy for multifocal PTC. In our study, the 131 I doses used to treat multifocal and unifocal PTC patients were not statistically different, and a higher rate of postoperative progression was noted in the multifocal group.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of Multifocal Papillary Thyroid Carcinoma

Kuo

Lin

Chao

et al. 2013

International Journal of Endocrinology

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This study was to investigate the clinical features and therapeutic outcomes of multifocal papillary thyroid microcarcinoma (PTMC). A total of 2,418 papillary thyroid carcinoma (PTC) patients had undergone thyroidectomy in one medical center between 1977 and 2010. There were 483 (20.0%) diagnosed with multifocal PTC. The percentage of multifocal PTC was higher in PTMC patients (22.0%) than in non-PTMC patients (19.5%). Demographic and clinical characteristics of PTMC and multifocal PTC in PTC patients were traced. Multifocal PTC patients presented with smaller tumors at an older age, and a higher percentage underwent total or complete thyroidectomy. These patients also showed a higher incidence of postoperative disease progression than did unifocal PTC patients. Comparison of 483 patients with multifocal PTMC and non-PTMC tumors showed a higher incidence of postoperative disease progression in patients with non-PTMC; otherwise, there was no statistical difference in disease-specific and total mortality between these two groups. In conclusion, the incidence of multifocal PTMC was not lower than that of non-PTMC, and postoperative therapies were necessary for both multifocal PTMC and non-PTMC patients.

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“…Ardito и соавт. [32] проанализировали дан-ные, полученные после 5,4 года наблюдения 149 па-циентов с микрокарциномами. Терапия радиоактив-ным йодом в ходе лечения проводилась 49 (33%) па-циентам.…”

Section: агрессивное лечение микрокарцином или их агрессивное течение?unclassified

“…Ученые схо-дятся во мнении, что монофокальная интратиреоид-ная микрокарцинома при наличии благоприятной гистологической формы и отсутствии метастазов в лимфатические узлы (минимальный риск) не тре-бует РЙТ [1,35]. При этом, по данным литературы, РЙТ при папиллярных микрокарциномах применя-ется в 31-100% случаев [11,32,51]. Несомненными показаниями к РЙТ являются: наличие регионарных и отдаленных метастазов, неполная резекция опухо-ли, группа высокого риска рецидива или летальности при полной резекции опухоли (T3, T4, M1, UICC, 7-е издание, 2010 г.)…”

Section: показания к рйтunclassified