Aggressive Periodontitis and its Multidisciplinary Focus:  Review of the Literature

Frías-Muñoz, Maribel; Araujo-Espino, Roxana; Martínez-Aguilar, Víctor Manuel; Alcalde, Teresina Correa; Aguilera-Galaviz, Luis; Gaitán-Fonseca, César

doi:10.15517/ijds.v19i3.28869

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Tooth decay and periodontitis are types of dental diseases caused by oral bacteria. Tooth decay leads to the formation of cavities, as known as dental caries, resulting from the growth of microbial biofilms that produce acid, infecting the enamel and dentine [2]. Periodontal disease is defined as an endogenous microbial disease that defects the tooth structure and periodontium [3].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Antibacterial Potential of Sarang Semut (Myrmecodia pendans) against Oral Pathogenic Bacteria: An In Vitro Study

Primasari¹,

Apriyanti²,

Ambardhani³

et al. 2022

TODENTJ

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Background: Dental diseases are generally caused by oral bacteria such as Enterococcus faecalis, Streptococcus mutans, and Streptococcus sanguinis. These bacteria have resistance to synthetic drugs; thus, it is required to discover new antibacterial agents. Sarang Semut (Myrmecodia pendans) has been empirically used as a medicinal plant to treat various conditions, including those caused by pathogenic bacteria. Objective: The present study was aimed to investigate the antibacterial activity of Sarang Semut extracts against E. faecalis, S. mutans, and S. sanguinis. Materials and Methods: Sarang Semut was extracted with several solvents to yield n-hexane, ethyl acetate, methanol, and water extracts. Each extract and combination were adjusted for assay with chlorhexidine, fosfomycin, and quercetin and used as positive controls. Results: The n-hexane extract showed activity with inhibition zone values of 7.15 and 10.45 ppm against E. faecalis and S. mutans at 1%, respectively. All combination extracts could inhibit the growth of E. faecalis and S. sanguinis. The synergistic effects resulting from the combination of extract-fosfomycin were also presented in this evaluation, with the strongest shown by water-fosfomycin against S. mutans, with inhibition zones of 28.5 mm at 1%. Conclusion: Sarang Semut extracts demonstrated antibacterial activity against oral pathogenic bacteria. These results offer alternative natural sources for the new antibacterial drug candidate.

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Section: Introductionmentioning

confidence: 99%

Formulation and Antibacterial Potential of Sarang Semut (Myrmecodia pendans) against Oral Pathogenic Bacteria: An In Vitro Study

Primasari¹,

Apriyanti²,

Ambardhani³

et al. 2022

TODENTJ

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“…Periodontitis is one of the most common periodontal diseases. It is a multifactorial disease that can be affected by genetic, environmental factors, living standards, and systemic diseases (AlJehani, 2014 ; Cheng et al, 2015 ; De Pablo et al, 2009 ; Frías‐Muñoz et al, 2018 ; Yoon et al, 2017 ). Data from previous studies have shown the different prevalence of periodontitis in the population, which is ranged from 13.5% to 83.5% (Balaji et al, 2018 ; Machado et al, 2018 ; Singh et al, 2012 ; Susin et al, 2011 ; Wellapuli & Ekanayake, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of P53 protein expression in gingival tissues of patients with chronic periodontitis by immunohistochemistry methods

Minabian

Torabi

et al. 2022

Clinical & Exp Dental Res

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Objective Periodontitis is one of the most important periodontal diseases that can be affected by many factors. Although the mechanism of periodontitis development is not yet fully understood, previous studies suggest that apoptosis may be one of the pathological factors that can affect the process of the disease by destroying old and damaged cells. Low expression of P53 protein is one of the reasons for delaying cell death that allows damaged cells to survive longer and gives more time for the chance of mutations and pathogenesis. Because of the important role of P53 in gingival cells of patients with chronic periodontitis, the objective of our study is to evaluate the P53 protein expression in gingival tissues of patients with chronic periodontitis by immunohistochemistry methods. Materials and Methods In this cross‐sectional study, 35 patients with severe to moderate chronic periodontitis (loss of attachment ≥3 mm, probing depth ≥5 mm) with no treatment and 25 people who were healthy for periodontal problems were examined. Gingival biopsies from marginal and attached gingiva were obtained, prepared, and mounted on slides. Then, the expression of P53 on each slide was evaluated by optic microscopy after using P53 antibodies and staining with hematoxylin‐eosin (immunohistochemistry method). Data were analyzed using independent t‐test, Mann–Whitney U‐test, and Spearman correlation test using SPSS Statistics version 18.0. Results The mean ages of participants in the case and control groups were 37.58 and 32.09, respectively. Our results showed that the expression of P53 was not significant in periodontitis compared to the control group (p > .05). Also, gender could not affect the expression of P53 in both groups (p > .05), and there was no significant relationship between age and P53 gene incidence. Conclusion Chronic periodontitis has no significant effect on P53 expression, so changes in apoptosis due to P53 expression in periodontitis are not significant.

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“…Chronic Periodontitis Disease (CPD) is a chronic multi-factorial inflammation disease because contribution of genetic and environmental factors as well as age, living standards and systemic diseases to initiation and progression of disease (1,2,3), which occurs in the supporting tissues of the tooth, that include gingiva , periodontal ligament , cementum and alveolar bone this is caused by the accumulation of bacterial groups on the surfaces of the teeth as well as between the teeth and thus will lead to side effects on the health gingiva due to the stimulation of the immune response against these bacterial assemblies that lead to damage and destroyed of gingival tissues and observed that the sensitivity of the host plays an important role in the initiation and development of chronic periodontitis (4,5). CPD is diagnosed by several indicators which include the presence and extent of periodontal pockets, loss of clinical attachment, pattern and extent of alveolar bone loss, or a combination of these findings (6).…”

Section: Introductionmentioning

confidence: 99%

Assessment of liver enzymes in saliva and serum of Iraqi patients with chronic periodontitis disease

Ridha¹,

Kadri²

2020

JoBRC

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Objective: The present study aimed to assess of four liver enzymes, Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP) and Gamma-Glutamyl Transpeptidase (GGT). Material and Methods: Based on periodontal clinical parameters, sixty four patients with chronic periodontitis (CP) and twenty four controls were enrolled in the study. Saliva and serum samples were collected and Automated Chemistry Analyzer AU 480 was employed to assess levels of enzymes. Results: Compared to healthy controls, the levels of the four enzymes were significant increased in serum of patients, especially in the severe group while in the saliva a significant increase observed only in the level of AST. Moreover, Alanine Aminotransferase (ALT), Aspartate Transaminase (AST), Alkaline Phosphatase (ALP) and Gamma-Glutamyl Transpeptidase (GGT) the levels of these enzymes in serum were significantly higher than those in saliva. Conclusion: ALT, AST, ALP and GGT serum levels are suggested to be important indicators for disease progression as well as predict the liver health.

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Aggressive Periodontitis and its Multidisciplinary Focus: Review of the Literature

Cited by 4 publications

References 13 publications

Formulation and Antibacterial Potential of Sarang Semut (Myrmecodia pendans) against Oral Pathogenic Bacteria: An In Vitro Study

Formulation and Antibacterial Potential of Sarang Semut (Myrmecodia pendans) against Oral Pathogenic Bacteria: An In Vitro Study

Evaluation of P53 protein expression in gingival tissues of patients with chronic periodontitis by immunohistochemistry methods

Assessment of liver enzymes in saliva and serum of Iraqi patients with chronic periodontitis disease

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