Aggressive Squamous Cell Carcinoma Originating as a Marjolinʼs Ulcer

SABIN, SHAWN R.; Goldstein, Glenn D.; Rosenthal, Howard G.; Haynes, Kimberly K.

doi:10.1097/00042728-200402000-00026

Cited by 2 publications

(2 citation statements)

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“…[14] For early prevention of this condition, diagnostic biopsies are recommended as part of wound care and repeated at frequent intervals and from multiple sites as necessary. [15] CONCLUSION As demonstrated in this study, awareness of the potential for malignant transformation in a wound over time is important, even though the wound may appear to be no more than a simple lesion. Marjolin's ulcer is likely to develop into SCC, and the prognosis can be poor.…”

Section: Discussionmentioning

confidence: 78%

From Basic Chronic Wounds To Mortal Endings; Squamous Cell Carsinom Arising From Hidradenitis Suppurativa and Pilonidal Sinus Diseases

Öz¹

2018

South Clin Ist Euras

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Marjolin's ulcer is an aggressive ulcerating malignancy that arises in a chronic wound and most often takes the form of squamous cell carcinoma (SCC). It often occurs in old burn scars, but it may also develop in post-traumatic lesions or chronic wounds. The prognosis is often poor as a result of delayed diagnosis. Presently described are cases in which chronic hidradenitis suppurativa and pilonidal sinus developed into SCC.

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Section: Discussionmentioning

confidence: 78%

From Basic Chronic Wounds To Mortal Endings; Squamous Cell Carsinom Arising From Hidradenitis Suppurativa and Pilonidal Sinus Diseases

Öz¹

2018

South Clin Ist Euras

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“…15,18 MUs in the lower limbs reportedly have higher rates of lymph node metastasis, distant metastasis, and recurrence. 19,20 However, these findings remain controversial.…”

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confidence: 99%

Prognostic factors of Marjolin’s ulcers: A Meta-analysis and Systemic Review Assisted with Machine Learning Techniques

Cheng

Liu

et al. 2022

Plastic &Amp; Reconstructive Surgery

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Marjolin ulcer (MU) is a malignant tumor that commonly arises from previously injured skin, including burn injuries, traumatic wounds, scars, and other chronic nonhealing inflammatory conditions. It most often develops in deep burn wounds with a prolonged Background: Marjolin ulcers (MUs) are malignant tumors arising from previously injured skin, including burn wounds, scars, chronic ulcers, and other chronic nonhealing inflammatory conditions. They have a potentially long latent period. The authors aimed to establish the prognostic factors for recurrence, metastasis, and disease-specific death related to MU. Methods: The authors performed a comprehensive search of PubMed, Embase, and the Cochrane Library. After assessing the methodologic quality of case series, they performed a meta-analysis and systematic review. Furthermore, the authors used machine learning to predict patient survival time. Results: MUs on the upper limbs, head, and neck had a higher risk of recurrence. Contrastingly, lower grade lesions, absence of lymph node metastasis, and a tumor diameter of less than 10 cm were associated with lower recurrence risk. The risks were unrelated to age and latent period. In addition, patients without lymph node metastasis had a lower risk of developing distant metastasis. Furthermore, the risk of disease-specific death was lower in patients with a lower tumor grade, absent lymph node metastasis, small tumor diameter (<10 cm), and tumors located in regions other than the head and neck. Correlation analysis showed that the age at initial injury was negatively correlated with the latent period of MU. Conclusions: The authors found that tumor grade, tumor site, lymph node status, and tumor size are important predictors of a worse prognosis. To integrate these predictors, the authors created an equation to predict the survival time for individual patients by means of machine learning processes. Moreover, the authors found that MU developed more quickly in older individuals with injuries.

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Aggressive Squamous Cell Carcinoma Originating as a Marjolinʼs Ulcer

Cited by 2 publications

References 4 publications

From Basic Chronic Wounds To Mortal Endings; Squamous Cell Carsinom Arising From Hidradenitis Suppurativa and Pilonidal Sinus Diseases

From Basic Chronic Wounds To Mortal Endings; Squamous Cell Carsinom Arising From Hidradenitis Suppurativa and Pilonidal Sinus Diseases

Prognostic factors of Marjolin’s ulcers: A Meta-analysis and Systemic Review Assisted with Machine Learning Techniques

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