Aggressive Squamous Cell Carcinomas in Persons Infected With the Human Immunodeficiency Virus

British HIV Association guidelines for HIV‐associated malignancies 2014

“…Immunochemotherapy has significantly improved outcome in the HIV-negative setting, and a number of reports suggest that the overall risk of CNS relapse has decreased with the addition of rituximab to CHOP chemotherapy [83][84][85] although this has not been detected in all reports [86]. This observation supports the hypothesis that CNS relapse is less likely to occur if there is improved control of systemic disease.…”

“…In the pre-HAART era, several chemotherapeutic agents (bleomycin, vinblastine, vincristine and etoposide) were shown to have activity against KS in case series and small Phase II trials using different combinations and doses of these drugs [84][85][86][87][88]. However, liposomal anthracyclines and taxanes have become established as the backbone of current standard systemic cytotoxic therapy against KS.…”

Highly aggressive squamous cell carcinoma in an HIV-infected patient

“…Five patients had well differentiated tumors, 4 had intermediately differentiated lesions and 1 had a poorly differentiated SCC. The authors also found that patients initially undergoing combination surgery and radiation therapy or radical neck dissection had the best outcomes 12 .…”

“…Nguyen and cols 12 recently reported a case series of 10 patients diagnosed with aggressive SCC based on rapid growth rate, a diameter of over 1.5cm, a history of recurrence and/or evidence of metastasis. A total of 41 SCC lesions were recorded from these 10 patients.…”

Human Immunodeficiency Virus (HIV) Positive Case with Squamous Cell Larynx Cancer: Difficulties in the Choice of Treatment

“…Laryngeal squamous cell carcinoma (SCC) is rarely encountered in human immunodeficiency virus (HIV)-positive patients compared to other HIV-related malignancies such as Kaposi's sarcoma and non-Hodgkin's lymphoma (1,2). Laryngeal SCC is observed at a younger age and in a more advanced stage, and it progresses more aggressively (3).…”