Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions

Murray, Kevin; Mahoney, Sophia; Venkatasubramanian, Ravinandan; Seals, Douglas R.; Clayton, Zachary S.

doi:10.1016/j.exger.2023.112105

Cited by 27 publications

(20 citation statements)

References 149 publications

(223 reference statements)

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“…Con ello será posible disminuir los riesgos cardiovasculares, el impacto económico y la carga de mortalidad por las ECV. [39][40][41][42][43][44][45]…”

Section: Discussionunclassified

La carga de enfermedades cardiovasculares en México, 1990-2021. Un resumen del estudio <i>Global Burden of Disease</i> 2021

Fajardo-Dolci,

Vicuña-De Anda,

Ortiz-Vázquez

et al. 2023

GMM

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Antecedentes: La enfermedad cardiovascular (ECV) es una causa importante de mortalidad, con implicaciones económicas para el sistema de salud. Objetivo: Caracterizar la carga de ECV en México de 1990 a 2021 con base en el estudio Global Burden of Disease (GBD), para abordar la carga de salud y enfermedad, sus implicaciones en la salud pública y el desarrollo del sistema de atención médica. Material y métodos: Se describe la mortalidad de las ECV en México y se examina en qué medida el crecimiento y el envejecimiento de la población explican las tendencias, las diferencias por sexo y los patrones geográficos. Resultados: Las ECV representan la primera causa de mortalidad, principalmente por cardiopatía hipertensiva, hemorragia intracerebral, hemorragia subaracnoidea, cardiopatía isquémica y accidente cerebrovascular isquémico. Se observó un cambio de tendencia en hombres y mujeres, mayor mortalidad en mayores de 80 años y en estados del norte del país. Conclusiones: México debe invertir en programas de salud pública para abordar los riesgos modificables, promover el envejecimiento saludable y reducir la muerte prematura por ECV.

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“…Con ello será posible disminuir los riesgos cardiovasculares, el impacto económico y la carga de mortalidad por las ECV. [39][40][41][42][43][44][45]…”

Section: Discussionunclassified

La carga de enfermedades cardiovasculares en México, 1990-2021. Un resumen del estudio <i>Global Burden of Disease</i> 2021

Fajardo-Dolci,

Vicuña-De Anda,

Ortiz-Vázquez

et al. 2023

GMM

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“…Increased physical activity, by way of aerobic exercise, is considered first-line therapy for improving peripheral vascular function with aging [102], particularly in ML/O adult men, with supportive but mixed evidence regarding its efficacy for improving peripheral vascular function in estrogen-deficient postmenopausal women [104]. The beneficial effects of aerobic exercise on the peripheral vasculature have shown to be directly mediated by or associated with reduced inflammation [55,[105][106][107], improved mitochondrial function [66,106,108] and lower burden of cellular senescence [84], which has been reviewed in detail elsewhere [109].…”

Section: Physical Activity/aerobic Exercisementioning

confidence: 99%

Peripheral vascular dysfunction and the aging brain

Wahl,

Clayton

2024

Aging

Self Cite

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Aging is the greatest non-modifiable risk factor for most diseases, including cardiovascular diseases (CVD), which remain the leading cause of mortality worldwide. Robust evidence indicates that CVD are a strong determinant for reduced brain health and all-cause dementia with advancing age. CVD are also closely linked with peripheral and cerebral vascular dysfunction, common contributors to the development and progression of all types of dementia, that are largely driven by excessive levels of oxidative stress (e.g., reactive oxygen species [ROS]). Emerging evidence suggests that several fundamental aging mechanisms (e.g., "hallmarks" of aging), including chronic lowgrade inflammation, mitochondrial dysfunction, cellular senescence and deregulated nutrient sensing contribute to excessive ROS production and are common to both peripheral and cerebral vascular dysfunction. Therefore, targeting these mechanisms to reduce ROS-related oxidative stress and improve peripheral and/or cerebral vascular function may be a promising strategy to reduce dementia risk with aging. Investigating how certain lifestyle strategies (e.g., aerobic exercise and diet modulation) and/or select pharmacological agents (natural and synthetic) intersect with aging "hallmarks" to promote peripheral and/or cerebral vascular health represent a viable option for reducing dementia risk with aging. Therefore, the primary purpose of this review is to explore mechanistic links among peripheral vascular dysfunction, cerebral vascular dysfunction, and reduced brain health with aging. Such insight and assessments of non-invasive measures of peripheral and cerebral vascular health with aging might provide a new approach for assessing dementia risk in older adults.

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“…This correlation was initially explained through the high saturated fat content of these food matrices, while now the involvement of the gut microbiota as a key point connecting animal-derived food and atherosclerosis is also widely recognized [ 35 ]. Together with diet, aerobic exercise has been shown to be one of the best lifestyle interventions to counteract endothelial dysfunction and promote the colonization of a healthy microbiota in the gut, especially in old age, where multiple cardiovascular risk factors coexist [ 36 ]. Indeed, the gut microbiota synthesizes a plethora of metabolites from dietary sources that could be beneficial or detrimental according to the host status, and the composition of the gut microbiota could be influenced by endurance exercise [ 37 , 38 , 39 , 40 , 41 ]; alterations in the microbiota diversity, named dysbiosis, is associated with metabolic disorders onset due to an imbalance in released metabolites.…”

Section: Endothelial Dysfunctionmentioning

confidence: 99%

Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite

Querio

Antoniotti

Geddo

et al. 2023

IJMS

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Endothelial function is essential in the maintenance of systemic homeostasis, whose modulation strictly depends on the proper activity of tissue-specific angiocrine factors on the physiopathological mechanisms acting at both single and multi-organ levels. Several angiocrine factors take part in the vascular function itself by modulating vascular tone, inflammatory response, and thrombotic state. Recent evidence has outlined a strong relationship between endothelial factors and gut microbiota-derived molecules. In particular, the direct involvement of trimethylamine N-oxide (TMAO) in the development of endothelial dysfunction and its derived pathological outcomes, such as atherosclerosis, has come to light. Indeed, the role of TMAO in the modulation of factors strictly related to the development of endothelial dysfunction, such as nitric oxide, adhesion molecules (ICAM-1, VCAM-1, and selectins), and IL-6, has been widely accepted. The aim of this review is to present the latest studies that describe a direct role of TMAO in the modulation of angiocrine factors primarily involved in the development of vascular pathologies.

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Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions

Cited by 27 publications

References 149 publications

La carga de enfermedades cardiovasculares en México, 1990-2021. Un resumen del estudio <i>Global Burden of Disease</i> 2021

La carga de enfermedades cardiovasculares en México, 1990-2021. Un resumen del estudio <i>Global Burden of Disease</i> 2021

Peripheral vascular dysfunction and the aging brain

Modulation of Endothelial Function by TMAO, a Gut Microbiota-Derived Metabolite

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