Aging amplifies a gut microbiota immunogenic signature linked to heightened inflammation
Maria Elisa Caetano-Silva,
Akriti Shrestha,
Audrey F. Duff
et al.
Abstract:Aging is associated with low-grade inflammation that increases the risk of infection and disease, yet the underlying mechanisms remain unclear. Gut microbiota composition shifts with age, harboring microbes with varied immunogenic capacities. We hypothesized the gut microbiota acts as an active driver of low-grade inflammation during aging. Microbiome patterns in aged mice strongly associated with signs of bacterial-induced barrier disruption and immune infiltration, including marked increased levels of circul… Show more
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