Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms

Albánez, Silvia; Ogiwara, Kenichi; Michels, Alison; Hopman, Wilma M.; Grabell, Julie; James, Paula; Lillicrap, David

doi:10.1111/jth.13294

Cited by 119 publications

(139 citation statements)

References 53 publications

(57 reference statements)

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“…1 and 2), as supported by other studies (Albánez et al, 2016; Favaloro et al, 2005). These may explain the higher incidence of thrombosis in older individuals, since Fbg, FVIII and VWF are the three acknowledged risk factors for thrombosis.…”

Section: Discussionsupporting

confidence: 87%

“…FVIII and VWF levels were significantly lower in O than in non-O groups, whereas no significant differences were calculated among the non-O groups (A, B and AB). Similar results have been confirmed in other populations in USA (Miller et al, 2003), Australia (Favaloro et al, 2005), Norway (Orstavik et al, 1985), Japan (Kokame et al, 2011), Brazil (Rios et al, 2012), Italy (Gallinaro et al, 2008), Canada (Albánez et al, 2016), and so on, which imply that the diversities of FVIII and VWF levels were partially determined by ABO blood types. This result may be explained by the variable clearance of VWF as an effect of the ABO glycosylation patterns.…”

Section: Discussionsupporting

confidence: 82%

“…This result may be explained by the variable clearance of VWF as an effect of the ABO glycosylation patterns. Although the mechanism of the effect of ABO on VWF levels is still unclear, the widely accepted hypothesis is that the significantly lower VWF levels in O-group subjects are due to a shorter VWF survival, which is mainly attributable to a faster clearance (Albánez et al, 2016; Casari et al, 2013; Gallinaro et al, 2008; Lenting, Christophe & Denis, 2015; Song et al, 2015). In a genome-wide association study, it was found that common variants in ABO and VWF genes explained about 18.7% of the variations in VWF levels (Desch et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

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Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Wang

Dou

et al. 2017

PeerJ

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BackgroundABO blood group is a hereditary factor of plasma levels of coagulation factor VIII (FVIII) and von Willebrand factor (VWF). Age and gender have been shown to influence FVIII, VWF, fibrinogen (Fbg), and ADAMTS13 (A disintegrin and metalloprotease with thrombospondin type 1 motif, 13). We investigated the effects of ABO type, age, and gender on plasma levels of FVIII, Fbg, VWF, and ADAMTS13 in a Chinese population.MethodsA total of 290 healthy volunteers were eligible for this study. ABO blood group was determined by indirect technique. FVIII:C and Fbg were measured by clotting assays. VWF antigen (VWF:Ag), collagen-binding activity (VWF:CBA), and ADAMTS13 antigen were assessed by ELISA, whereas VWF ristocetin cofactor activity (VWF:Rcof) was performed by agglutination of platelets with ristocetin.ResultsMean FVIII:C and VWF levels (VWF:Ag, VWF:CBA, and VWF:Rcof) were significantly higher in non-O than in O type subjects (p < 0.05 for all comparison). ADAMTS13 antigen decreased with increasing age, whereas the other parameters increased. Other than ADAMTS13 (p < 0.01), no gender-related variations were observed in the other parameters. Moreover, FVIII:C, Fbg, VWF:Ag, VWF:CBA, and VWF:Rcof showed significant and positive relationships with age (r = 0.421, 0.445, 0.410, 0.401, and 0.589, resp.; all p < 0.001), whereas a negative relationship was observed for ADAMTS13 antigen (r = 0.306; p = 0.006). Furthermore, FVIII:C were strongly correlated with VWF:Ag, VWF:CBA, and VWF:Rcof (r = 0.746, r = 0.746, and r = 0.576, resp.; p < 0.0001). VWF parameters were also strongly correlated with each other (r = 0.0.847 for VWF:Ag and VWF:CBA; r = 0.722 for VWF:Ag and VWF:Rcof; p < 0.0001).ConclusionsABO blood group, age, and gender showed different effects on plasma levels of FVIII:C, Fbg, VWF:Ag, VWF:CBA, VWF:Rcof, and ADAMTS13 antigen. These new data on a Chinese population are quite helpful to compare with other ethnic groups.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Wang

Dou

et al. 2017

PeerJ

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“…Albanez S, et al [19] showed the influence of age and the ABO group on the plasma concentration of coagulation factor [19,20]. We were not able to study this point as this parameter was not recorded in our study.…”

Section: Discussioncontrasting

confidence: 47%

Determining Concentrations of Factors VIII, IX and Fibrinogen in Fresh Frozen Plasma: An Alternative to Improve Treatment of Hemorrhagic Diseases in a Developing Country

Diallo¹

2017

HIJ

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Fresh frozen plasma (FFP) remains the only treatment of bleeding events in some developing countries. But access to this blood derived-product could be difficult. Determined the concentrations of coagulation factors VIII, IX and fibrinogen used in Mali. We have determined prospectively the concentrations of these factors from October 2015 to Conclusion:Concentrations of coagulation factors in the FFP bags produce by NBTC are 1.6 fold lower for factor VIII, and 2.3 fold for factor IX than in other countries. We suggest that the production and distribution of cryoprecipitate could be improved for the effective management of bleeding events in resource-limited countries with no access to specific concentrate coagulation factor.

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“…As a functional assay, VWF ristocetin cofactor (VWF:RCo) levels <30 U/dL are strongly associated with a clinical bleeding phenotype and the presence of an identified VWF mutation in type 1 VWD 12. Other genetic factors that influence VWF levels, including the “platelet type” of VWD18 ( GP1BA mutation) and the ABO blood groups 19. Newer associations between VWF antigen levels and polymorphisms in non-VWF genes have been identified by genome wide association studies, including polymorphisms in secretory protein genes, such as STAB5 , STX2 , and STXBP5 20.…”

Section: The Genetics and Synthesis Of Vwfmentioning

confidence: 99%

Von Willebrand Disease in the elderly: clinical perspectives

Chapin

2018

CIA

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Von Willebrand disease (VWD) is an inherited bleeding disorder that affects up to 1% of the population. In most cases, VWD results from a mutation in the von Willebrand Factor (VWF) gene, which alters the amount and function of VWF, a key glycoprotein in both primary and secondary hemostasis. A comprehensive analysis of patients with VWD should include VWF activity, antigen levels, platelet function, and a careful bleeding history. Treatment options include antifibrinolytics, desmopressin, and VWF replacement therapy. VWF levels fluctuate due to age, stress, environmental exposures, and pharmacologic treatment. Treatment guidelines exist to treat and prevent bleeding for patients undergoing surgery and medical procedures, but often these must be reevaluated in the setting of age-related comorbidities including cardiovascular events, venous thrombosis, and malignancy. In addition, many age-related complications are associated with a secondary acquired von Willebrand syndrome (AVWS), including malignancies, hypothyroidism, cardiovascular diseases, and cardiac replacement devices. The current literature is limited by a lack of older patients in clinical trials. Larger studies are needed to determine if age-related comorbidities affect VWD patients at different frequencies than the general elderly population. There is also a significant need for registry-based studies to evaluate many age-related comorbidities in VWD patients.

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Aging and ABO blood type influence von Willebrand factor and factor VIII levels through interrelated mechanisms

Cited by 119 publications

References 53 publications

Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Influences of ABO blood group, age and gender on plasma coagulation factor VIII, fibrinogen, von Willebrand factor and ADAMTS13 levels in a Chinese population

Determining Concentrations of Factors VIII, IX and Fibrinogen in Fresh Frozen Plasma: An Alternative to Improve Treatment of Hemorrhagic Diseases in a Developing Country

Von Willebrand Disease in the elderly: clinical perspectives

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