Aging and diabetic retinopathy: Inherently intertwined pathophysiological processes

Li, Qingbo; Wang, Mengqi; Li, Xiaorong; Shao, Yan

doi:10.1016/j.exger.2023.112138

Cited by 10 publications

(5 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a result of diabetes, many metabolic changes occur within the cell, leading to an increased level of oxidative stress, which may contribute to the regression of telomere length [45] . There was also an association between DR and increased oxidative stress and activation of proin ammatory signaling pathways [19,46] . As a result of chronic hyperglycemia induces a set of metabolic abnormalities that enhance ROS generation and ultimately lead to oxidative stress in the retina, resulting in retinal cell apoptosis and irregular function of the retina [47] .…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of age-related cardiovascular events is in uenced by several aging biomarkers, including telomere length, DNA methylation age, somatic cell mutations, and in ammatory markers [16] . Research progress has indicated that a number of factors contribute to the pathogenesis of DR, including senescence-associated secretory phenotypes, advanced glycation end products, oxidative stress on the endoplasmic reticulum, and impaired autophagy [17][18][19] . CVH is an appropriate prevention and management strategy for reducing the burden of DR due to its close association with established cardiovascular disease (CVD) risk factors.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phenotypic age and biological age mediate the association between Life's Essential 8 and diabetic retinopathy among US adults

Wang,

Jin,

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Cardiovascular disease (CVD) is closely associated with Diabetic retinopathy (DR), and the prevalence of DR is steadily increasing. Life's Essential 8 (LE8), a recently updated assessment of cardiovascular health (CVH), was examined in this study to determine if it was related to diabetes among adults in the United States. Methods 316 DR participants and 2,314 non-DR participants were included in the analyses using data from the National Health and Nutrition Examination Survey (NHANES) database (2005–2018). LE8 scores, derived from eight individual metrics, were categorized into three groups: low (0–49), moderate (50–74), and high (75–100). Combining certain biomarker sets allowed for the measurement of both phenotypic age (PA) and biological age (BA). In order to evaluate the relationship between LE8 scores and DR, weighted logistic regression and linear analysis were used. The mediating function of PA and BA was investigated by mediation analysis. Results After adjusting for all covariates, higher LE8 scores were associated with a lower risk of DR (odds ratio [OR], 0.49; 95% confidence interval [CI], 0.26–0.93; P for trend = 0.027). A 10-score increase in LE8 score was related to a 17% decrease in the risk of DR (multivariate-adjusted OR = 0.83, 95% CI: 0.73–0.95). Mediation analysis indicated that PA and BA partially mediated 47.57% and 28.11% of the association between LE8 scores and DR, respectively. Conclusion A negative association was found between LE8 scores and the presence of DR, possibly mediated by PA and BA. As a result of these findings, encouraging adherence to optimal CVH levels may be beneficial in reducing the prevalence of DR.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phenotypic age and biological age mediate the association between Life's Essential 8 and diabetic retinopathy among US adults

Wang,

Jin,

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…DR is a most common complications of diabetes mellitus, whose hallmark, i.e., hyperglycaemia, is associated with increased accumulation of ROS in different tissues, including the retina [ 43 ].…”

Section: Oxidative Stress and Eye Pathologiesmentioning

confidence: 99%

Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases

Rodella

Honisch

Gatto³

et al. 2023

Nutrients

View full text Add to dashboard Cite

This review aims to discuss the delicate balance between the physiological production of reactive oxygen species and the role of antioxidant nutraceutical molecules in managing radicals in the complex anatomical structure of the eye. Many molecules and enzymes with reducing and antioxidant potential are present in different parts of the eye. Some of these, such as glutathione, N-acetylcysteine, α-lipoic acid, coenzyme Q10, and enzymatic antioxidants, are endogenously produced by the body. Others, such as plant-derived polyphenols and carotenoids, vitamins B2, C, and E, zinc and selenium, and omega-3 polyunsaturated fatty acids, must be obtained through the diet and are considered essential nutrients. When the equilibrium between the production of reactive oxygen species and their scavenging is disrupted, radical generation overwhelms the endogenous antioxidant arsenal, leading to oxidative stress-related eye disorders and aging. Therefore, the roles of antioxidants contained in dietary supplements in preventing oxidative stress-based ocular dysfunctions are also discussed. However, the results of studies investigating the efficacy of antioxidant supplementation have been mixed or inconclusive, indicating a need for future research to highlight the potential of antioxidant molecules and to develop new preventive nutritional strategies.

show abstract

“…Changes in RPE cells become more pronounced with increased oxidative stress and the development of chronic ocular diseases such as cataracts, glaucoma, age-related macular degeneration (AMD), Stargardt disease and diabetic retinopathy [11,[17][18][19]. Thus, AMD is characterized by the chronic and progressive degeneration of RPE cells, photoreceptors and retinal neurons [20].…”

Section: Introductionmentioning

confidence: 99%

Retinal Pigment Epithelium Pigment Granules: Norms, Age Relations and Pathology

Dontsov,

Ostrovsky

2024

IJMS

View full text Add to dashboard Cite

The retinal pigment epithelium (RPE), which ensures the normal functioning of the neural retina, is a pigmented single-cell layer that separates the retina from the Bruch’s membrane and the choroid. There are three main types of pigment granules in the RPE cells of the human eye: lipofuscin granules (LG) containing the fluorescent “age pigment” lipofuscin, melanoprotein granules (melanosomes, melanolysosomes) containing the screening pigment melanin and complex melanolipofuscin granules (MLG) containing both types of pigments simultaneously—melanin and lipofuscin. This review examines the functional role of pigment granules in the aging process and in the development of oxidative stress and associated pathologies in RPE cells. The focus is on the process of light-induced oxidative degradation of pigment granules caused by reactive oxygen species. The reasons leading to increased oxidative stress in RPE cells as a result of the oxidative degradation of pigment granules are considered. A mechanism is proposed to explain the phenomenon of age-related decline in melanin content in RPE cells. The essence of the mechanism is that when the lipofuscin part of the melanolipofuscin granule is exposed to light, reactive oxygen species are formed, which destroy the melanin part. As more melanolipofuscin granules are formed with age and the development of degenerative diseases, the melanin in pigmented epithelial cells ultimately disappears.

show abstract

Aging and diabetic retinopathy: Inherently intertwined pathophysiological processes

Cited by 10 publications

References 116 publications

Phenotypic age and biological age mediate the association between Life's Essential 8 and diabetic retinopathy among US adults

Phenotypic age and biological age mediate the association between Life's Essential 8 and diabetic retinopathy among US adults

Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases

Retinal Pigment Epithelium Pigment Granules: Norms, Age Relations and Pathology

Contact Info

Product

Resources

About