Aging and head and neck cancer insights from single cell and spatial transcriptomic analyses
Yi Pei,
Zhuying Mou,
Lai Jiang
et al.
Abstract:Background
Head and neck squamous cell carcinoma(HNSCC) is the sixth most common malignancy worldwide, with more than 890,000 new cases and 450,000 deaths annually. Its major risk factors include smoking, alcohol abuse, aging, and poor oral hygiene. Due to the lack of early and effective detection and screening methods, many patients are diagnosed at advanced stages with a five-year survival rate of less than 50%. In this study, we deeply explored the expression of Aging-related genes(ARGs) in HNS… Show more
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