Aging and HIV

Justice, Amy C.; Falutz, Julian

doi:10.1097/coh.0000000000000081

Cited by 27 publications

(13 citation statements)

References 34 publications

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“…Although results of the present study highlight the potential combined effects of meth and HIV for HPA dysregulation, we were unable to examine the association of HIV alone without a METH-HIV+ group in this study. There is increasing recognition of persistent inflammation in treated HIV infection (Lederman et al, 2013), which is thought to be due in part to intestinal damage by HIV and could be augmented by alcohol or other substance use (Justice & Falutz, 2014). HIV-induced increases in pro-inflammatory cytokines such as IL-6 could bind to adrenal inflammatory receptors and amplify cortisol output independent of prevailing ACTH levels (Path et al, 1997).…”

Section: | Discussionmentioning

confidence: 99%

Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive, methamphetamine‐using men who have sex with men

Rodriguez

Jones

Kumar

2017

Human Psychopharmacology

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Results: There were no group differences in prevailing adrenocorticotropic hormone (ACTH) or cortisol levels, but the association between ACTH and cortisol was moderated by METH + HIV+ group (β = −0.19, p < .05). Compared to METH-HIV− men, METH + HIV+ MSM displayed 10% higher log 10 cortisol levels per standard deviation lower ACTH. Both groups of methamphetamine-using MSM had lower insulin resistance and greater syndemic burden (i.e., sleep disturbance, severe depression, childhood trauma, and polysubstance use disorder) compared to METH-HIV− men. However, the disaggregated functional relationship between ACTH and cortisol in METH + HIV+ MSM was independent of these factors. Conclusions:Further research is needed to characterize the bio-behavioral pathways that explain dysregulated HPA axis functioning in HIV-positive, methamphetamine-using MSM.

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Section: | Discussionmentioning

confidence: 99%

Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive, methamphetamine‐using men who have sex with men

Rodriguez

Jones

Kumar

2017

Human Psychopharmacology

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“…We conducted an anonymous online survey from March to August 2016 with PLWH who reported at least one of the following HANA conditions: asthma, bronchitis, cardiovascular disease, COPD, diabetes, liver disease, osteoporosis, renal failure, or arthritis. We selected these conditions after reviewing the literature and consulting with experts in the field;[44–51] these conditions are the most frequent causes of morbidity and mortality in PLWH. To be eligible to participate in the study, individuals had to: be at least 18 years of age, provide informed consent, report having at least 1 HANA condition, and read/write in English.…”

Section: Methodsmentioning

confidence: 99%

Self-Management Strategies for Coping with Adverse Symptoms in Persons Living with HIV with HIV Associated Non-AIDS Conditions

et al. 2017

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People living with HIV (PLWH) are living longer, but many are now affected by HIV-associated non-AIDS (HANA) conditions and their associated adverse symptoms. An online survey was conducted with 769 PLWH with HANA conditions in the US. Information was elicited on symptoms experienced, self-management strategies employed, and the helpfulness of these strategies. Open ended responses were collected for self-management strategies. A qualitative data analytic approach was used to organize the 4036 self-management strategies into thematic categories, with eight main categories emerging, including: taking medication, modifying activity, altering diet, seeking help, waiting, substance use, managing thoughts and attitudes, and altering the physical environment. Of the self-management strategy subcategories, social support was the most helpful self-management strategy with waiting/doing nothing being the least helpful approach. Findings can be used to inform the development of self-management interventions and to support health care professionals in recommending symptom self-management strategies to their patients.

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“…HANA conditions included: asthma, bronchitis, cardiovascular disease, COPD, diabetes, liver disease, osteoporosis, renal failure, or arthritis. 34,35 For the sex-based analysis, the data collected in the follow-up reproductive status survey was linked through study identifiers to the data collected in the original symptom survey. All data were entered into a data management program ( Excel ), and data integrity and assumptions were checked.…”

Section: Data Management and Analysismentioning

confidence: 99%

In people living with HIV (PLWH), menopause (natural or surgical) contributes to the greater symptom burden in women: results from an online US survey

et al. 2018

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Aging and HIV

Cited by 27 publications

References 34 publications

Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive, methamphetamine‐using men who have sex with men

Short circuit: Disaggregation of adrenocorticotropic hormone and cortisol levels in HIV‐positive, methamphetamine‐using men who have sex with men

Self-Management Strategies for Coping with Adverse Symptoms in Persons Living with HIV with HIV Associated Non-AIDS Conditions

In people living with HIV (PLWH), menopause (natural or surgical) contributes to the greater symptom burden in women: results from an online US survey

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