Aging and Kyphosis

Gerhard, Glenn S.; Kasales, Claudia J.

doi:10.1093/gerona/58.11.b968

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…Consistent with our data, a similar decrease in mineral density in both vertebrae and femur bone was earlier reported in intrinsically aged mice (Kalu, 1995). Kyphosis (curvature of the spine), as observed in the mutant and intrinsically aged mice, may be linked to osteoporosis with loss of trabecular bone in vertebral bodies of the middorsal spine or to muscle atrophy (Gerhard & Kasales, 2003) or a combination thereof, as most likely in our model. In humans, osteoporosis causes kyphosis through the deformity of the vertebral bodies (Cummings & Melton, 2002).…”

Section: Discussionmentioning

confidence: 88%

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

et al. 2010

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SummaryThe free radical theory of aging postulates that the production of mitochondrial reactive oxygen species is the major determinant of aging and lifespan. Its role in aging of the connective tissue has not yet been established, even though the incidence of aging-related disorders in connective tissue-rich organs is high, causing major disability in the elderly. We have now addressed this question experimentally by creating mice with conditional deficiency of the mitochondrial manganese superoxide dismutase in fibroblasts and other mesenchymederived cells of connective tissues in all organs. Here, we have shown for the first time that the connective tissuespecific lack of superoxide anion detoxification in the mitochondria results in reduced lifespan and premature onset of aging-related phenotypes such as weight loss, skin atrophy, kyphosis (curvature of the spine), osteoporosis and muscle degeneration in mutant mice. Increase in p16 INK4a , a robust in vivo marker for fibroblast aging, may contribute to the observed phenotype. This novel model is particularly suited to decipher the underlying mechanisms and to develop hopefully novel connective tissuespecific anti-aging strategies.

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Section: Discussionmentioning

confidence: 88%

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

et al. 2010

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The Efficacy of Manual Therapy on Musculoskeletal Pain in Menopause: A Systematic Review

Espírito Santo,

Moita,

Nunes

2024

Healthcare

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(1) Background: The aim of this review was to evaluate the effects of manual therapy for musculoskeletal pain in menopausal women. (2) Methods: A comprehensive search of manuscripts published from inception until 29 February 2024 was conducted on PubMed, EBSCO Information Services (EBSCOhost), Physiotherapy Evidence Database (Pedro), Web of Science, Scientific Electronic Library Online (SciELO), Cochrane Central Register of Controlled Clinical Trials, and Scopus using Medical Subject Headings (MeSH) and free terms. Randomized controlled trials (RCT) investigating the effects of manual therapy for musculoskeletal pain in postmenopausal women were included. Articles published in non-English or non-Portuguese languages, case reports, expert opinions, dissertations, conference papers, and gray literature were excluded. Studies were screened for population, musculoskeletal pain, intervention, and pain outcome by two independent reviewers using an ad hoc data extraction form. (3) Results: A total of 5 RCTs (4 with high risk of bias and 1 with low risk of bias) were included (total sample = 245), addressing thumb carpometacarpal osteoarthritis, thoracic kyphosis, chronic neck and backache, knee osteoarthritis, and sternocostal joint pain. The combined results of these studies showed improved musculoskeletal pain in menopausal women; duration of the follow-up was between 4 weeks to 6 months. Conclusions: The majority of studies included in this systematic review were effective in reducing musculoskeletal pain in menopausal women. These results come mainly from studies with a high risk of bias with small sample sizes, and the most representative follow-up period was short-term. Therefore, the results of this systematic review should be interpreted with caution.

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Aging and Kyphosis

Cited by 2 publications

References 8 publications

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

The Efficacy of Manual Therapy on Musculoskeletal Pain in Menopause: A Systematic Review

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