Aging and the cornea

Faragher, R. G. A.; Mulholland, B. J.; Tuft, Stephen; Sandeman, Susan; Khaw, PT

doi:10.1136/bjo.81.10.814

Cited by 121 publications

(80 citation statements)

References 56 publications

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“…Wong et al (2002) also reported a negative correlation (r = -0.237, p<0.01) between CCT and age in adult Hong Kong Chinese. The thinner CCT reported for older age group has been attributed to a decline in the density of keratocytes and a probable breakdown in the collagen fibers in the aging cornea (Faragher et al, 1997). Previous studies in Nigeria described no significant association between CCT and age in normotensives (Iyamu and Ituah, 2008).…”

Section: Discussionmentioning

confidence: 84%

The Relationship between Central Corneal Thickness and Intraocular Pressure in Adult Nigerians without Glaucoma

Iyamu¹,

Kio²,

Idu³

et al. 2011

Sierra Leone j. biomed. res.

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The aim of this study was to investigate the relationship between central corneal thickness (CCT) and intraocular pressure (IOP) in a predominantly black population. A total of eighty-five subjects (right eyes) with mean age 44.7 ± 15.1 years consisting of 49 males and 36 females were recruited for this study. The central corneal thickness was measured by ultrasound pachymetry (SW-1000P pachymeter, Tianjin Suowei Electronic Technology, China) and intraocular pressure with Keeler Pulsair EasyEye Non-contact tonometer (Keeler Instruments, USA). The mean CCT for the studied population was 550.0 ± 36.3µm, while the mean IOP was 15.0 ± 2.6mmHg. Although there was a downward trend in the central corneal thickness towards the older age, the association between CCT and age was significant (r=-0.25, p=0.021). However, the association between intraocular pressure and age was not significant (r=0.091, p=0.41). There was no significant association between CCT and IOP (r=0.052, p=0.64). Neither central corneal thickness nor intraocular pressure was influenced by age. There was no significant association between central corneal thickness and intraocular pressure.

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Section: Discussionmentioning

confidence: 84%

The Relationship between Central Corneal Thickness and Intraocular Pressure in Adult Nigerians without Glaucoma

Iyamu¹,

Kio²,

Idu³

et al. 2011

Sierra Leone j. biomed. res.

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“…On average, our results showed a mean endothelial cell count of 26547341/mm 2 (1SD), with a range of 1960-3691 endothelial cells/mm 2 . Detailed results are shown in Table 1.The breakdown of mean endothelial cell density by age clearly shows decreasing cell counts with increasing age (Figure 2).…”

Section: Sir Corneal Endothelial Cell Density In a Normal Pakistani mentioning

confidence: 87%

Corneal endothelial cell density in a normal Pakistani population

Ashraf

Saeed

Zia

2005

Eye

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“…This significant increase represented progressive age related changes in cornea such as arcus senilis, vogt's white limbal gridle, farinata etc. These degenerative but benign conditions are common in elderly and thus not considered as exclusion criteria for the study [18,19].…”

Section: Discussionmentioning

confidence: 99%

Normal Values of Corneal Optical Densitometry Using Pentacam Scheimpflug Camera

Asrar¹,

Ikram²,

Khan³

et al. 2016

AOVS

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Purpose: The purpose of the study was to illustrate the range of normal values of corneal densitometry using Pentacam Scheimpflug camera. Methodology:Prospective study was conducted at tertiary care Amanat eye hospital. 490 eyes of 490 participants of different age groups were added. All scans were performed in diagnostics room with uniform ambient light, performed by trained ophthalmic technologist. All participants were Pakistani of different ethnic groups. Only one eye of each participant was included to control biasness. T test, One-way ANOVA, pearson correlation coefficient and linear regression model tests were applied for analysis.Results: 490 eyes; 247 right eyes and 243 left eyes were analyzed. Mean age was 41.7±15.27 years (range 20-81 years) with 48.4% male and 51.6% females. based on corneal depth; highest backward scattering of light was observed in anterior (120 µm) layer (20.6±8.52 GSU) than central and posterior layers 13.6±5.17 GSU and 11.7±3.99 GSU respectively. The difference was statistically significant among layers with p< 0.001. Based on corneal surface, minimum backscattering was noted in central 0-6mm zone which increases from central to limbal zone; 0-2mm zone was 13.2±3.81 GSU, 2-6mm zone was 12.6±3.68 GSU, 6-10mm zone was 16.0±8.90 GSU and 10-12mm zone was 22.1±8.26 GSU. The difference was statistically significant with p<0.001. Significant correlation of corneal densitometry and age was observed r= 0.677, p<0.001. Conclusion:Objective assessment of corneal densitometry can be made with Pentacam Scheimpflug. Normative values of corneal density may be used in routine clinical practice and provided a reference for future research.

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Aging and the cornea

Cited by 121 publications

References 56 publications

The Relationship between Central Corneal Thickness and Intraocular Pressure in Adult Nigerians without Glaucoma

The Relationship between Central Corneal Thickness and Intraocular Pressure in Adult Nigerians without Glaucoma

Corneal endothelial cell density in a normal Pakistani population

Normal Values of Corneal Optical Densitometry Using Pentacam Scheimpflug Camera

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