Aging exacerbates the morphological and mechanical response of mineralized collagen fibrils in murine cortical bone to disuse

Liu, Fa; Hu, Ke; Al-Qudsy, Luban H.; Wu, Lan-Qin; Wang, Zhe; Xu, Huiyun; Ye, Hui; Yang, Pengfei

doi:10.1016/j.actbio.2022.08.064

Cited by 9 publications

(5 citation statements)

References 69 publications

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“…After 5 weeks, all pores were filled with minerals and deposited over the surface of the scaffold. The SEM images revealed that mineral deposition increased with the deposition time [57,58].…”

Section: In Vitro Bio-mineralization Studymentioning

confidence: 98%

Eggshell-Mediated Hematite Nanoparticles: Synthesis and Their Biomedical, Mineralization, and Biodegradation Applications

Ayub,

Bashir,

Majid

et al. 2023

Crystals

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The present study demonstrates the synthesis of phase pure hematite (α-Fe2O3) nanoparticles (NPs) using collagen protein and calcium carbonate extracted from eggshell membranes and eggshells, respectively, as organic additives. To test the influence of organic additives on the quality of the resulting NPs, the amount of eggshell powder was varied between 1 to 5 g in aqueous iron nitrate solution. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and RAMAN analysis confirmed the formation of hematite NPs without any impurities. FTIR spectra revealed the presence of polyphenolic constituents on the surface of the resulting NPs as stabilizers, which may potentially be responsible for the observed antioxidant and antibacterial properties. Furthermore, the stable phase and the presence of low defects divulged the high hardness value (~983 HV) and fracture toughness (8.59 MPa m1/2), which can be exploited for bone implantation. The FE-SEM results demonstrate the formation of spherical particles, which are well-separated NPs. The results of a biodegradation study which was carried out in phosphate-buffered saline (PBS) revealed that the as-prepared NPs retained their hardness even after 72 h of soaking. These prepared NPs showed 95% radical scavenging activity (RSA) and were good carriers against S. aureus bacteria. Moreover, the SEM images of the mineralization of iron oxide NPs confirmed the formation of new bone. After 5 weeks, all pores were filled, and the minerals were deposited on the surfaces of the scaffolds.

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Section: In Vitro Bio-mineralization Studymentioning

confidence: 98%

Eggshell-Mediated Hematite Nanoparticles: Synthesis and Their Biomedical, Mineralization, and Biodegradation Applications

Ayub,

Bashir,

Majid

et al. 2023

Crystals

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show abstract

“…Open sites for mineral nucleation, proteoglycan binding, and crosslinking are provided by the D-periodic spacing of MCF. The deposition of minerals is facilitated by the appropriate arrangement of collagen fibrils, which also enhances the bone’s mechanical qualities [ 53 ]. Because of the mentioned properties, this polymer found its applications in TE of bone grafts ( Figure 3 ) [ 54 ].…”

Section: Materials Used For 3d Scaffold Engineeringmentioning

confidence: 99%

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Vach Agocsova,

Culenova,

Birova

et al. 2023

Materials

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This article provides a thorough overview of the available resorbable biomaterials appropriate for producing replacements for damaged tissues. In addition, their various properties and application possibilities are discussed as well. Biomaterials are fundamental components in tissue engineering (TE) of scaffolds and play a critical role. They need to exhibit biocompatibility, bioactivity, biodegradability, and non-toxicity, to ensure their ability to function effectively with an appropriate host response. With ongoing research and advancements in biomaterials for medical implants, the objective of this review is to explore recently developed implantable scaffold materials for various tissues. The categorization of biomaterials in this paper includes fossil-based materials (e.g., PCL, PVA, PU, PEG, and PPF), natural or bio-based materials (e.g., HA, PLA, PHB, PHBV, chitosan, fibrin, collagen, starch, and hydrogels), and hybrid biomaterials (e.g., PCL/PLA, PCL/PEG, PLA/PEG, PLA/PHB PCL/collagen, PCL/chitosan, PCL/starch, and PLA/bioceramics). The application of these biomaterials in both hard and soft TE is considered, with a particular focus on their physicochemical, mechanical, and biological properties. Furthermore, the interactions between scaffolds and the host immune system in the context of scaffold-driven tissue regeneration are discussed. Additionally, the article briefly mentions the concept of in situ TE, which leverages the self-renewal capacities of affected tissues and highlights the crucial role played by biopolymer-based scaffolds in this strategy.

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“…Thanks to its high biocompatibility, the resulting scaffold can reduce brain lesions and neuronal cell death, while also mitigating neuroinflammation. Derived from biological tissues, collagen can play a crucial role in specific areas of the human body, such as forming the basic mineralized structure in bone tissue to support its mechanical strength [66]. During wound healing, collagen I and collagen III could serve as effective cellular scaffolds, facilitating the formation of new blood vessels and epithelial coverage [67].…”

Section: Involving the Tissue Recoverymentioning

confidence: 99%

Structure, extraction, processing, and applications of collagen as an ideal component for biomaterials - a review

et al. 2023

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Collagen with a multi-hierarchical architecture exhibits powerful biological performance, thus being developed in biomedical applications as a processing building block. The isolated collagen after extraction from biological tissues can be processed into various forms such as fibrils, scaffolds, membranes, microspheres, hydrogels, and sponges for further use in specific applications. This review briefly discusses the multi-hierarchical structure, powerful biological performances, extraction, and processing approaches of collagen as a natural biomaterial. The processing of collagen including dissolution, self-assembly, cross-linking, and electrospinning, is discussed to show more feasibility for specific applications of collagen composite biomaterials. Further emphasis is directed towards the biomedical applications of drug and gene delivery, as well as tissue repair involving bone, cartilage, vascular, and corneal, along with wound healing. Additionally, there is a focus on the development of flexible sensors and electronic skins (e-skins). Furthermore, the potential challenges and perspectives for the development of collagen-based biomaterials are proposed. In short, collagen-based biomaterials are expected to facilitate sustainable development and the next generation of advanced biomaterial applications. Graphical Abstract

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Aging exacerbates the morphological and mechanical response of mineralized collagen fibrils in murine cortical bone to disuse

Cited by 9 publications

References 69 publications

Eggshell-Mediated Hematite Nanoparticles: Synthesis and Their Biomedical, Mineralization, and Biodegradation Applications

Eggshell-Mediated Hematite Nanoparticles: Synthesis and Their Biomedical, Mineralization, and Biodegradation Applications

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Structure, extraction, processing, and applications of collagen as an ideal component for biomaterials - a review

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