Aging in the circadian system: Considerations for health, disease prevention and longevity

Gibson, Elaine; Williams, Wilbur P.; Kriegsfeld, Lance J.

doi:10.1016/j.exger.2008.05.007

Cited by 139 publications

(98 citation statements)

References 70 publications

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“…Chronic disruptions in circadian function are associated with an increase in a variety of disease states, including heart disease, ulcers and diabetes [72]. With advanced age, the genes regulating circadian function at the cellular level become disorganized.…”

Section: Agingmentioning

confidence: 99%

Melatonin and Circadian Rhythm: Aging, Cancer, and Mechanism

Kovacic¹,

Somanathan²

2014

OJPM

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The circadian clock is involved with many aspects of biological processes in animals and plants. Melatonin is a pineal hormone which is known to play a widespread role in the biochemistry of the circadian clock. The present review addresses the clock and melatonin in relation to aging and cancer, which are important aspects of medicine and biochemistry. The literature contains a large variety of associations of these areas with melatonin and circadian rhythm. Mechanistic aspects are addressed with emphasis on the unifying theme based on electron transfer-free radicalsoxidative stress.

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Section: Agingmentioning

confidence: 99%

Melatonin and Circadian Rhythm: Aging, Cancer, and Mechanism

Kovacic¹,

Somanathan²

2014

OJPM

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“…Chronic disruptions in the sleep ⁄ wake cycle inherent in a career in EM may be associated with an increase in a variety of disease states including heart disease, ulcers, cancer, and diabetes. 22,23 Although these health risks are not generational, advancing age increases the probability of disease. 18 Attitude toward shift work differs significantly between generations.…”

Section: Clinical Workmentioning

confidence: 99%

Generational Influences in Academic Emergency Medicine: Structure, Function, and Culture (Part II)

Mohr

Smith‐Coggins

Larrabee

et al. 2011

Academic Emergency Medicine

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Strategies for approaching generational issues that affect teaching and learning, mentoring, and technology in emergency medicine (EM) have been reported. Tactics to address generational influences involving the structure and function of the academic emergency department (ED), organizational culture, and EM schedule have not been published. Through a review of the literature and consensus by modified

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“…77 Moreover, aging and hypertension were also known to affect the internal circadian rhythm. 78,79 Several studies have addressed the second question, which is whether an impaired circadian clock affects disease progression. Penev et al 80,81 repeated phase shifts of the light/dark cycle in cardiomyopathic hamsters and found that disruption of rhythmicity strikingly enhanced disease progression and resulted in shortened longevity.…”

Section: Roles Of the Peripheral Clock In Cardiovascular Diseasesmentioning

confidence: 99%

Circadian clock and vascular disease

Takeda

Maemura

2010

Hypertens Res

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Cardiovascular functions, including blood pressure and vascular functions, show diurnal oscillation. Circadian variations have been clearly shown in the occurrence of cardiovascular events such as acute myocardial infarction. Circadian rhythm strongly influences human biology and pathology. The identification and characterization of mammalian clock genes revealed that they are expressed almost everywhere throughout the body in a circadian manner. In contrast to the central clock in the suprachiasmatic nucleus (SCN), the clock in each tissue or cell is designated as a peripheral clock. It is now accepted that peripheral clocks have their own roles specific to each peripheral organ by regulating the expression of clock-controlled genes (CCGs), although the oscillation mechanisms of the peripheral clock are similar to that of the SCN. However, little was known about how the peripheral clock in the vasculature contributes to the process of cardiovascular disorders. The biological clock allows each organ or cell to anticipate and prepare for changes in external stimuli. Recent evidence obtained using genetically engineered mice with disrupted circadian rhythm showed a novel function of the internal clock in the pathogenesis of endothelial dysfunction, hypertension and hemostasis. Loss of synchronization between the central and peripheral clock also contributes to the pathogenesis of cardiovascular diseases, as restoration of clock homeostasis could prevent disease progression. Identification of CCGs in each organ, as well as discovery of tools to manipulate the phase of each biological clock, will be of great help in establishing a novel chronotherapeutic approach to the prevention and treatment of cardiovascular disorders.

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Aging in the circadian system: Considerations for health, disease prevention and longevity

Cited by 139 publications

References 70 publications

Melatonin and Circadian Rhythm: Aging, Cancer, and Mechanism

Melatonin and Circadian Rhythm: Aging, Cancer, and Mechanism

Generational Influences in Academic Emergency Medicine: Structure, Function, and Culture (Part II)

Circadian clock and vascular disease

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