Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine

Rakov, Helena; Angelis, Meri De; Renko, Kostja; Hönes, Georg Sebastian; Zwanziger, Denise; Moeller, Lars C.; Schramm, Karl‐Werner; Führer, Dagmar

doi:10.1089/thy.2018.0377

Cited by 22 publications

(40 citation statements)

References 27 publications

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“…For a comprehensive analysis of age-effects on organ-specific TH homeostasis and HPT axis, we studied C57BL/6 mice at 3 and 22 months and analysed age effects on circulating and tissue TH concentrations, target gene expression and Dio1 activity. We found lower free T 4 concentrations in serum of old compared to young mice, which were associated with decreased TH tissue concentrations in liver and hearts in the old animals [24]. Others reported T 3 and TSH serum concentrations to increase with age, whereas TH content of the brain, heart and muscle were not altered, but hepatic and renal T 3 concentrations decreased [23].…”

Section: Ageing Alters Thyroid Function and Th Action In Tissuessupporting

confidence: 43%

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Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses

Kerp

Gassen

Führer

2020

Exp Clin Endocrinol Diabetes

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Age and sex impact prevalence and clinical features of thyroid disease. Thyroid dysfunction occurs with a higher frequency in elderly patients and females. Moreover, age alters clinical presentation of hyper- and hypothyroidism and onset of thyroid hormone (TH) related co-morbidities leading to increased risk for underdiagnosis and maltreatment in the elderly. Rodent models allow further insights into mechanisms of age- and sex-dependent TH action in target tissues. In this review, we summarize findings from mouse studies showing distinct effects of age and sex on systemic versus organ-specific TH action and discuss their wider implication for clinical care.

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Section: Ageing Alters Thyroid Function and Th Action In Tissuessupporting

confidence: 43%

“…In a further study we challenged 3 and 23 months old male mice with a single T 4 injection [24]. Even though this resulted in comparable TSH suppression in both age groups, a significantly smaller increment of serum T 3 after T 4 injection was found in the old mice.…”

Section: Acute Thyroxine Challenge Unmasks Age Impact On Th Metabolismmentioning

confidence: 90%

Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses

Kerp

Gassen

Führer

2020

Exp Clin Endocrinol Diabetes

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“…It is also important to mention that tissue responsiveness to TH may vary with age and sex, which may be related to tissue-specific alterations in T4 to T3 conversion. 122–124 The interplay between age and sex are particularly interesting in TH-induced changes in body weight and energy expenditure in mice, with sex modifying the response of TH differently in old males compared with old females. 122–124…”

Section: Introductionmentioning

confidence: 99%

The role of thyroid hormone in metabolism and metabolic syndrome

Teixeira

Santos

Pazos‐Moura

2020

Therapeutic Advances in Endocrinology

125

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Metabolic syndrome (MetS) and thyroid dysfunction are common in clinical practice. The objectives of this review are to discuss some proposed mechanisms by which thyroid dysfunctions may lead to MetS, to describe the bidirectional relationship between thyroid hormones (THs) and adiposity and finally, to resume a list of recent studies in humans that evaluated possible associations between thyroid hormone status and MetS or its clinical components. Not solely THs, but also its metabolites regulate metabolic rate, influencing adiposity. The mechanisms enrolled are related to its direct effect on adenosine triphosphate (ATP) utilization, uncoupling synthesis of ATP, mitochondrial biogenesis, and its inotropic and chronotropic effects. THs also act controlling core body temperature, appetite, and sympathetic activity. In a bidirectional way, thyroid function is affected by adiposity. Leptin is one of the hallmarks, but the pro-inflammatory cytokines and also insulin resistance impact thyroid function and perhaps its structure. MetS development and weight gain have been positively associated with thyroid-stimulating hormone (TSH) in several studies. Adverse glucose metabolism may be related to hyperthyroidism, but also to reduction of thyroid function or higher serum TSH, as do abnormal serum triglyceride levels. Hypo- and hyperthyroidism have been related to higher blood pressure (BP), that may be consequence of genomic or nongenomic action of THs on the vasculature and in the heart. In summary, the interaction between THs and components of MetS is complex and not fully understood. More longitudinal studies controlling each of all confounding variables that interact with endpoints or exposure factors are still necessary.

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“…Thyroid tests depend on age. TSH increases with age and is thus found in lower normal ranges in younger subjects [1,2]. It is generally accepted that optimal thyroid tests are important for reproduction (e.g., Korevaar et al [3]).…”

Section: Introductionmentioning

confidence: 99%

Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

Karbownik-Lewińska

Stępniak

Żurawska

et al. 2020

IJERPH

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High-normal TSH can be associated with metabolic abnormalities and infertility. Aims of this study are to analyze retrospectively if routinely measured blood laboratory and anthropometric parameters differ between women of reproductive age with TSH < 2.5 mIU/L and with TSH ≥ 2.5 mIU/L. Retrospective analysis was performed in 466 female inpatients, aged 13–51, hospitalized in an endocrine department. The group of 280 patients with normal thyroid tests (TSH 0.27-4.2 mIU/L; normal FT3 and FT4) was selected and it was divided into two subgroups, i.e., with TSH < 2.5 mIU/L and TSH ≥ 2.5 mIU/L (n = 66; 23.6%). After excluding patients on L-thyroxine treatment (n = 240), those with TSH ≥ 2.5 mIU/L constituted 22.92% (n = 55). In the group of 280 patients with normal thyroid tests, an abnormally high concentration of triglycerides and an abnormally low HDLC/cholesterol ratio occurred more frequently in women with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (17% vs. 7%, p = 0.017; 14% vs. 5%, p = 0.015, respectively). Increased concentration of thyroid antibodies, i.e., TPOAb, occurred more frequently in patients with TSH ≥ 2.5 mIU/L than those with TSH < 2.5 mIU/L (27% vs. 9%, p = 0.001). The same differences were found in the group of 240 patients after excluding those on L-thyroxine treatment. Blood lymphocyte concentration was the only independent linear parameter associated with TSH ≥ 2.5 mIU/L (OR = 1.551, p = 0.024) but only in the group of 280 patients with normal thyroid tests. TSH concentration correlated positively with blood lymphocyte (r = 0.129, p = 0.031) and TPOAb (r = 0.177, p = 0.005) concentrations but only in the group of 280 patients with normal thyroid tests. Less favorable lipid profiles and a higher prevalence of thyroid antibodies in women of reproductive age with high-normal TSH suggests that L-thyroxine treatment should be considered in such patients. The significance of a positive association between high-normal TSH and blood lymphocytes requires further evaluation.

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Aging Is Associated with Low Thyroid State and Organ-Specific Sensitivity to Thyroxine

Cited by 22 publications

References 27 publications

Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses

Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses

The role of thyroid hormone in metabolism and metabolic syndrome

Less Favorable Lipid Profile and Higher Prevalence of Thyroid Antibodies in Women of Reproductive Age with High-Normal TSH—Retrospective Study

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