Aging Lung: Molecular Drivers and Impact on Respiratory Diseases—A Narrative Clinical Review
Paweł Górski,
Adam J. Białas,
Wojciech J. Piotrowski
Abstract:The aging process significantly impacts lung physiology and is a major risk factor for chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), asthma, and non-IPF interstitial lung fibrosis. This narrative clinical review explores the molecular and biochemical hallmarks of aging, such as oxidative stress, telomere attrition, genomic instability, epigenetic modifications, proteostasis loss, and impaired macroautophagy, and their roles in lung se… Show more
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