Aging Mechanisms: Linking oxidative stress, obesity and inflammation

Abstract

Aging cannot be defeated in anyway in the world even having new and advanced technology. But molecular mechanism is a successful method to control aging. Many complex and multifunctional factors are the main cause of aging. It is evident that the studies regarding cellular, genetic, and pathological and biochemical changes are exploring more and more pathways linking various diverse mechanism explaining aging. Implications of basic mechanisms of aging for improving both longevity and quality of life in human needs a clear understanding and takes a long time. However, reactive oxygen species (ROS) indicate a growing body even in the presence of fundamental mechanisms. According to oxidative stress theory, advanced and permanent addition of oxidative damage on critical aspects of aging process instigated by ROS influences. Telomeres theory is another, new aging theory that holds many promising possibilities for the field of anti-aging medicine. The theory was originated from the surge of technological breakthroughs in genetics and genetic engineering. Telomeres have also been found related to obesity. Obesity also leads to accelerated cellular processes. A "causative agent in aging" is considered inflammation that underlies a mechanism showing that for survival acute inflammatory response is necessary but long term exposure to different antigens than predicted by evolution cause low-grade inflammatory status which intern contributes to age-associated illness and death. The condition known as "inflammaging".

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

“…Numerous age-related diseases undergo the inflammation process, which is a risk factor in or partly of disease development (DeBalsi et al, 2017 ). For instance, several age-related diseases including diabetes, dementia, metabolic syndrome, osteoporosis, cancer, arthritis, and cardiovascular diseases have been recognized as inflammatory disorders (Tan et al, 2015b ; Abbas et al, 2017 ; Liu et al, 2017 ). The interaction between inflammation and oxidative stress is tightly associated with the prostaglandins (PGs) biosynthetic pathway that produces reactive species (Kawahara et al, 2015 ).…”

Hallmarks of Aging: An Autophagic Perspective

“…The ROS are considered metabolites of molecular oxygen during cellular respiration, being very reactive due to an unpaired electron (40). Mitochondria are the major ROS producers and perhaps the organelle most affected by them.…”

Detector location selection based on VIP analysis in near-infrared detection of dural hematoma

“…Most hematomas caused by traumatic brain injury are positioned extradurally or intradurally under the skull, which is located at the third level, i.e. the cerebrospinal fluid level in the brain model (Bullock et al, 2006, Abbas et al, 2017). When traumatic brain hematoma occurs, the absorption coefficient of the dural position will increase significantly.…”