Agminated blue nevi: a case series and updated dermoscopic review

Abstract

Blue nevi, usually presenting as solitary, bluish, asymptomatic macules or nodules, are formed by collections of dermal melanocytes that failed to complete their migration from the neural crest to the dermo-epidermal junction. The term "agminated blue nevi" refers to multiple lesions grouped, linear, or arranged in a blashkoid distribution. It is a relatively rare phenomenon with less than 35 cases reported in the literature, but only 14 cases with dermoscopic features. We report another 4 cases along with an updated dermoscopic review.

Diagnostic Imaging of Agminated Blue Lesions and Blue Lesions with Satellitosis: Case Series with a Concise Review of the Current Literature

“…Currently, there are 32 cases regarding agminated blue nevi (ABN) published so far in the literature [2][3][4][5][6][7]10,11,14,15,[20][21][22][23][24][25][26][27][28][29][57][58][59][60] (Table 2). The term agminated, by some authors, has also been replaced by other terms such as "plaque-type" or "patch-type" in order to define blue nevi clustered in an area ≤ 10 cm.…”

“…ABN association with GNAQ and CYSLTR2 mutations has been reported in the literature, though in sporadic cases [60]. ABN usually arises as single and solitary cutaneous lesions; however, associations with nevus spilus, exophthalmus, pre-tibial myxoedema, osteoarthropathia (EMO syndrome) and dermatomyositis as well as Darier's disease have been reported in the literature [2][3][4][5][6][7]10,11,14,15,[20][21][22][23][24][25][26][27][28][29][57][58][59][60]. A malignant transformation with a melanoma arising in a previous ABN has been reported [61,62].…”