Agomelatine could prevent brain and cerebellum injury against LPS-induced neuroinflammation in rats

Savran, Mehtap; Aslankoç, Rahime; Özmen, Özlem; Erzurumlu, Yalçın; Savaş, Hasan Basri; Temel, Esra Nurlu; Koşar, Pınar Aslan; Boztepe, Saim

doi:10.1016/j.cyto.2019.154957

Cited by 40 publications

(29 citation statements)

References 59 publications

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“…Some drugs that are not originally developed to regulate sirtuins have currently been found to have neuroprotective properties via a SIRT-involved pathway. For instance, the long-acting glucagon-like peptide-1 analogs, liraglutide ( He et al, 2020 ), agomelatine ( Savran et al, 2020 ), and dexmedetomidine ( Chen et al, 2019 ), exert a SIRT1-dependent neuroprotective effect and critically regulate the metabolism. Furthermore, the antibiotic, minocycline, modulates SIRT3 to protect BBB integrity ( Yang et al, 2015 ), and bexarotene attenuates neuroinflammation by modulating SIRT6 ( Zuo et al, 2019 ).…”

Section: Sirtuins As Promising Therapeutic Targetsmentioning

confidence: 99%

Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?

et al. 2020

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Traumatic brain injury (TBI), a leading cause of morbidity worldwide, induces mechanical, persistent structural, and metabolic abnormalities in neurons and other brain-resident cells. The key pathological features of TBI include neuroinflammation, oxidative stress, excitotoxicity, and mitochondrial dysfunction. These pathological processes persist for a period of time after TBIs. Sirtuins are evolutionarily conserved nicotinamide-adenine dinucleotide (NAD+)-dependent deacetylases and mono-ADP-ribosyl transferases. The mammalian sirtuin family has seven members, referred to as Sirtuin (SIRT) 1-7. Accumulating evidence suggests that SIRT1 and SIRT3 play a neuroprotective role in TBI. Although the evidence is scant, considering the involvement of SIRT2, 4-7 in other brain injury models, they may also intervene in similar pathophysiology in TBI. Neurodegenerative diseases are generally accepted sequelae of TBI. It was found that TBI and neurodegenerative diseases have many similarities and overlaps in pathological features. Besides, sirtuins play some unique roles in some neurodegenerative diseases. Therefore, we propose that sirtuins might be a promising therapeutic target for both TBI and associated neurodegenerative diseases. In this paper, we review the neuroprotective effects of sirtuins on TBI as well as related neurodegeneration and discuss the therapeutic potential of sirtuin modulators.

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Section: Sirtuins As Promising Therapeutic Targetsmentioning

confidence: 99%

Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?

et al. 2020

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“…LPS is an endotoxin in the cell wall of gram-negative bacteria and has been used to evoke inflammation in the nervous system. LPS releases tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), which causes inflammation-mediated neuronal damage [4]. Moreover, neuroinflammation induced by LPS showed excessive apoptosis in the brain [5,6].…”

Section: Introductionmentioning

confidence: 99%

Voluntary Wheel Running Improves Spatial Learning Memory by Suppressing Inflammation and Apoptosis via Inactivation of Nuclear Factor Kappa B in Brain Inflammation Rats

2020

Int Neurourol J

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Purpose: Exercise has been shown to protect against diverse brain diseases. Voluntary exercise improves cognition and has a neuroprotective effect. The aim of this investigation is to study the effect of voluntary wheel running on brain inflammation in rats with regard to inflammation and apoptosis.Methods: Brain inflammation was caused by intracranial injection of lipopolysaccharide using a stereotaxic instrument. Voluntary wheel running group were conducted during 21 consecutive days, staring 2 days after brain inflammation.Results: Brain inflammation increased proinflammatory cytokine production and apoptosis cell death in the hippocampus. There changes in the hippocampus deteriorated spatial learning memory. However, voluntary wheel running suppressed the secretion of inflammatory cytokines and apoptotic neuronal cell death via inactivation of nuclear factor kappa B (NF-κB)/NF-κB inhibitor-α pathway. Voluntary wheel running also promoted the recovery of the spatial learning memory impairment.Conclusions: Voluntary wheel running after brain inflammation enhanced spatial learning memory by suppressing proinflammatory cytokine secretion and apoptosis cell death. Voluntary wheel running is also expected to be effective in inflammatory diseases of the urogenital system.

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“…The increase in antioxidant capacity in response to the increase in oxidative stress may mislead the measurement of TOS only in terms of causing oxidative damage, cell, tissue, and organ damage. By comparing the change in the TOS / TAS ratio, an accurate comparison is possible by eliminating the potentially misleading antioxidant reactive response for oxidative damage [21][22][23]. Thanks to TAS, TOS and OSI values, information and interpretation can be made about the oxidant-antioxidant capacity status, which is known to have a role in the etiology of many diseases, including pathologies with neurological and central nervous system involvement [21].…”

Section: Discussionmentioning

confidence: 99%

“…Disulfide (µmol / l) / alb (g / l). Oxidative stress index = total oxidant status / total antioxidant status) [19][20][21][22][23][24][25][26][27]. The results of hemogram and Vitamin B12, 25 OH D levels were retrospectively taken from their files.…”

Section: Laboratory Analysismentioning

confidence: 99%

Thiol Disulfide Balance Oxidative Stress and Paraoxonase 1 Activities in Children and Adolescents Aged 6-16 Years with Specific Learning Disorders

Savaş¹,

Sayar

Kara³

2021

ELECTRON J GEN MED

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Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters.Methods: All participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. Total oxidant status, total antioxidant status, thiol balance, ischemia modified albumin, paraoxonase 1 activity, arylesterase activity, zinc and copper levels were measured by the spectrophotometric methods.Results: Compared to the control, the SLD group had statistically significantly lower values for PON1 antioxidant enzyme activity (p=.045), ARY antioxidant enzyme activity (p<.001), 25 OH Vitamin D (p=.005), reduced thiol ratio (p=.028), thiol oxidation reduction ratio (p=.01), native thiols (p=.024) and significantly higher values for total oxidant status (p=.017), oxidized thiol ratio (p=.028). Conclusion:The relationship between oxidative stress and SLD diagnosis in our results will be very important if it is supported by further new studies. In this case, evaluation of vitamin D, oxidative stress, antioxidant status and thiol balance may come to the agenda in the diagnosis and treatment of SLD.

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Agomelatine could prevent brain and cerebellum injury against LPS-induced neuroinflammation in rats

Cited by 40 publications

References 59 publications

Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?

Will Sirtuins Be Promising Therapeutic Targets for TBI and Associated Neurodegenerative Diseases?

Voluntary Wheel Running Improves Spatial Learning Memory by Suppressing Inflammation and Apoptosis via Inactivation of Nuclear Factor Kappa B in Brain Inflammation Rats

Thiol Disulfide Balance Oxidative Stress and Paraoxonase 1 Activities in Children and Adolescents Aged 6-16 Years with Specific Learning Disorders

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