Agricultural Practices Affect Arthritis

Newnham, Rex E.

doi:10.1177/026010609100700204

Cited by 23 publications

(12 citation statements)

References 10 publications

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“…Over 50 years of research has concluded that boron is essential for healthy bones and joints . Researchers have also observed that there is a difference in the concentration of boron in arthritic bones (3 ppm) and in healthy bones (56 ppm) . The presence of boron has an influence in a variety of metabolic actions, and it is known that boron interacts with calcium, vitamin D, and magnesium which are all significant for the bone metabolism process .…”

Section: Discussionmentioning

confidence: 99%

“…25 Researchers have also observed that there is a difference in the concentration of boron in arthritic bones (3 ppm) and in healthy bones (56 ppm). 26 The presence of boron has an influence in a variety of metabolic actions, and it is known that boron interacts with calcium, vitamin D, and magnesium which are all significant for the bone metabolism process. 27 Although the underlying mechanisms of the B activity are still being investigated, in recent years, scientists have started to exploit boron-based BG for bone TE applications.…”

Section: Discussionmentioning

confidence: 99%

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Ion Release, Hydroxyapatite Conversion, and Cytotoxicity of Boron‐Containing Bioactive Glass Scaffolds

Balasubramanian

Grünewald

Detsch

et al. 2016

Int J of Appl Glass Sci

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We report the development and characterization of boron‐releasing highly porous three‐dimensional bioactive glass (BG) scaffolds fabricated by the foam replica technique. Three types of bioactive glasses with (wt%) 0.2%, 12.5%, 25% B2O3, and related varying SiO2 contents (wt%): 50%, 37.5%, and 25%, were investigated. The well‐known 13‐93 (silicate) and 13‐93B3 (borate) (in wt% – 56.6% B2O3, 5.5% Na2O, 11.1% K2O, 4.6% MgO, 18.5% CaO, 3.7% P2O5) BGs were used as controls to study the influence of the presence of boron on the mechanical properties, surface reactivity, and cytotoxicity of scaffolds. Surface morphology and surface properties of the BG scaffolds were measured. X‐ray diffraction (XRD) analyses showed that the scaffolds of all five compositions were amorphous. The scaffolds with 12.5 wt% B2O3 exhibited satisfactory compressive strength in the range of 1–2 MPa. A dissolution study in cell culture medium was carried out, and ion release profiles, and apatite formation of the scaffolds were assessed. The cytotoxicity of the scaffolds was evaluated using a stromal cell line (ST2). Cells were found to attach and spread well on the scaffolds' surfaces. We conclude that borosilicate scaffolds containing 12.5 wt% B2O3 provide the best combination of properties, including relatively high mechanical strength, apatite formation, and cytocompatibility, and thus, they are promising candidates for bone tissue engineering.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ion Release, Hydroxyapatite Conversion, and Cytotoxicity of Boron‐Containing Bioactive Glass Scaffolds

Balasubramanian

Grünewald

Detsch

et al. 2016

Int J of Appl Glass Sci

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“…A between country comparison suggests that the prevalence of arthritis is inversely proportional to the level of boron in soil and subsequently the food supply [38]. Given the effect of boron on steroid hormone metabolism, it may also impact on arthritis by increasing the synthesis of corticosteroids.…”

Section: Discussionmentioning

confidence: 99%

Elevation of biosynthesis of endogenous 17‐B oestradiol by boron supplementation: One possible role of dietary boron consumption in humans

Naghii¹,

Mofid

2008

Journal of Nutritional & Environmental Medicine

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Background. Recent evidence indicates that boron has a widespread role in biochemistry and nutrition and may have anti-carcinogenic properties. It interacts with calcium, vitamin D and magnesium, which are all important in bone metabolism. Boron also increases steroid hormone concentrations in animals and humans and hints at a role in the prevention of chronic diseases such as osteoporosis, arthritis and other steroid hormone dependent diseases. It has been suggested that the interaction between boron and steroid hormone metabolism is mediated by the hydroxylation process that steroids need to be biologically active. Thus, the aim of this study was to investigate the effect of boron supplementation on the selected steroid hormone productions or steroidogenesis. Methods. The experimental design consisted of two trials, in two different occasions. Seven healthy male volunteers in one group and another nine healthy male volunteers in the second group consumed two tablets each containing 5 mg of boron per day and blood samples were collected prior to supplementation and after 4 and 8 weeks.Results. The mean total testosterone concentrations increased after supplementations. The mean plasma 17-B oestradiol concentrations increased significantly after 4 weeks (p50.009) and 8 weeks (p50.05) supplementations. The ratio of 17-B oestradiol to testosterone increased significantly (p50.01) after 4 weeks supplementation.Conclusions. It can be speculated that the elevation of endogenous oestrogen as a result of boron supplementation suggests a potential protective role for boron in preventing a number of clinical conditions or chronic diseases, with emphasis in animals or humans who are under stress conditions, which requires further studies and clarifications.

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“…Boron could counteract the effect of peroxide. A possible explanation might be the ability of boron to prevent free radical mediated damage in vivo, which has been demonstrated earlier [22,24]. Size exclusion chromatography of iron-containing proteins exposed to peroxides indicates a change in the elution volume (V e ) of Cyt c (Fig.…”

Section: Discussionmentioning

confidence: 55%