Agroclimatic regionalization is an effective way to utilize agricultural climate resources in a reasonable manner. Accurate and objective agroclimatic regionalization plays a great directive role in ecological layout and decision support for agriculture farming. The purpose of this article was to investigate the influence of climate change on agroclimatic regions in China. Following the same regionalization principle concept as the theory and techniques of agroclimatic regionalization, three agroclimatic regions, the Tibetan High Cold Region (THCR), Northwest Arid Region (NAR), and Eastern Monsoon Region (EMR) were identified in China. The changes in the three agroclimatic regions were analyzed from 1961 to 2020 in the past and from 2006 to 2060 in the future. Future changes in agroclimatic regions were estimated from 2006 to 2030 and from 2031 to 2060 under scenarios RCP2.6, RCP4.5, and RCP8.5 for greenhouse gas emissions. The borders of agoclimatic regions had changed as a result of global climate warming and precipitation variability. There was a surplus in the geographical displacement and range of agroclimatic region borders in 1991 to 2020, especially when compared to those in 1961–1990. The TCHR exhibited significant spatial variation, with its northeast corner shifting nearly 170 km to the southwest. In the future, the area ratio of the THCR will be 26% by 2031–2060 under the RCP8.5 scenario, with the highest decline (1% compared to that in the reference period of 1981–2005), while under the RCP4.5 and RCP2.6 scenarios it will stabilize the area ratio at 27%. The eastern boundary of the NAR will migrate south or east, while the center boundary will rise northward. Under all three climatic scenarios, the area ratio will be 25% (down 1%). The range of the EMR will expand. The area ratio of the EMR will increase by 1% under the RCP2.6 and RCP4.5 scenarios and by 2% under the RCP8.5 scenario. Overall, our study may facilitate an in-depth understanding of agroclimatic regions changes and thus provide a scientific reference for the distribution of agricultural production and sustainable development under climate change in China.