AHNAK-modified microbubbles for the intracranial delivery of triptolide: In-vitro and in-vivo investigations

Feng, Yunjiang; An, Rui; Zhang, Yajun; Chen, Mingjun; Wang, Li; Duan, Yun-you; Xing, Changyang

doi:10.1016/j.ijpharm.2022.122351

Cited by 4 publications

(2 citation statements)

References 65 publications

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“…Subsequently, other researchers also observed the beneficial effect of LITUS in PD animal models ( 114 – 119 ). With the advent of ultrasound combined with microbubble technology, an increasing number of researchers have used this technology to enhance blood-brain-barrier permeability to achieve local drug release in the treatment of PD ( 120 – 122 ).…”

Section: Ultrasonic Stimulation In Central Nervous System Diseasementioning

confidence: 99%

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

Ye²,

Liang³

et al. 2023

Front. Neurol.

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Transcranial ultrasound stimulation is a neurostimulation technique that has gradually attracted the attention of researchers, especially as a potential therapy for neurological disorders, because of its high spatial resolution, its good penetration depth, and its non-invasiveness. Ultrasound can be categorized as high-intensity and low-intensity based on the intensity of its acoustic wave. High-intensity ultrasound can be used for thermal ablation by taking advantage of its high-energy characteristics. Low-intensity ultrasound, which produces low energy, can be used as a means to regulate the nervous system. The present review describes the current status of research on low-intensity transcranial ultrasound stimulation (LITUS) in the treatment of neurological disorders, such as epilepsy, essential tremor, depression, Parkinson's disease (PD), and Alzheimer's disease (AD). This review summarizes preclinical and clinical studies using LITUS to treat the aforementioned neurological disorders and discusses their underlying mechanisms.

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Section: Ultrasonic Stimulation In Central Nervous System Diseasementioning

confidence: 99%

Transcranial low-intensity ultrasound stimulation for treating central nervous system disorders: A promising therapeutic application

Ye²,

Liang³

et al. 2023

Front. Neurol.

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“…We note, however, that the therapeutic effects reported by Zhang et al [129] were also observed in control groups that received nanobubbles without FUS. Feng, et al [132] used FUS to facilitated the delivery of Triptolide (T 10 ) into the brains of alpha-synucleinoverexpressing mice. Triptolide is a compound found in a Chinese medicinal herb that has been found to increase autophagy of alpha-synuclein in vitro [133] but does not easily cross the BBB [134].…”

Section: Fus-mb Animal Modelsmentioning

confidence: 99%

Noninvasive Neuromodulation in Parkinson’s Disease: Insights from Animal Models

Muksuris,

Scarisbrick,

Mahoney

et al. 2023

JCM

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The mainstay treatments for Parkinson’s Disease (PD) have been limited to pharmacotherapy and deep brain stimulation. While these interventions are helpful, a new wave of research is investigating noninvasive neuromodulation methods as potential treatments. Some promising avenues have included transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroconvulsive therapy (ECT), and focused ultrasound (FUS). While these methods are being tested in PD patients, investigations in animal models of PD have sought to elucidate their therapeutic mechanisms. In this rapid review, we assess the available animal literature on these noninvasive techniques and discuss the possible mechanisms mediating their therapeutic effects based on these findings.

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