AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

“…Nrf2, a redox sensitive transcription factor, has been reported to play critical roles in regulating antioxidant and inflammatory responses (Huang et al, 2015). In normal conditions, Nrf2 is sequestered in the cytoplasm and bound with Keap1 (Sid et al, 2014). Activating of Nrf2 could induce the expression of HO-1, which has been demonstrated to have antioxidant activity (Juan et al, 2005;Reisman et al, 2009).…”

Linalool Inhibits LPS-Induced Inflammation in BV2 Microglia Cells by Activating Nrf2

“…Nrf2 is the primary transcription factor which plays an important role in regulating inflammatory and antioxidant responses [23]. Normally, Nrf2 is sequestered in the cytoplasm and combined with its inhibitors Keap1 [24]. Once stimulating, Nrf2 translocates to the nucleus and regulates the transcription of antioxidant proteins such as HO-1 [25,26].…”

5-Aminoimidazole-4-carboxyamide-1-β-D-ribofranoside stimulates the ratenhancer of split- and hairy-related protein-2gene via atypical protein kinase C lambda

“…It is well known that the AMPK directly phosphorylates peroxisome-proliferator-activated receptor g coactivator 1a in muscle (32). In contrast, recent report showed that AICAR induced Nrf2 activation by an AMPK-independent mechanism (33). Although it remains to be determined the mechanism which how AICAR stimulates transcription of the rat SHARP-2 gene, SHARP-2 could be added to a list of the AICAR-responsive transcription factors.…”