Aichi Cancer Center Initial Experience of Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer Using Helical Tomotherapy

Kodaira, Takeshi; Tomita, Natsuo; Tachibana, Hideki; Nakamura, Tatsuya; Nakahara, Rie; Inokuchi, Haruo; Fuwa, Nobukazu

doi:10.1016/j.ijrobp.2008.06.1936

Cited by 32 publications

(27 citation statements)

References 22 publications

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“…Our previous studies also support this result [12,13]. In general, the CTV includes the retropharyngeal nodal regions, Levels Ib, II, III, IV and V in bilateral neck sites for NPC [8,25,26]. However, in this study, the incidences of contralateral LN metastasis existed only at Level II and in the retropharyngeal LN with low frequency among most patients with primary tumours within the midline of the nasopharynx.…”

Section: Nodal Metastasis In Nasopharyngeal Cancersupporting

confidence: 79%

Factors associated with nodal metastasis in nasopharyngeal cancer: an approach to reduce the radiation field in selected patients

Tomita

Fuwa²,

Ariji³

et al. 2011

BJR

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Objectives: The purpose of this study was to investigate factors associated with lymph node (LN) metastasis to identify which nasopharyngeal cancer (NPC) patients can undergo a reduction in the prophylactic radiation field. MRI of biopsy-proven NPC patients was evaluated to determine primary tumour extension and the existence of LN metastasis. Methods: Sex, age, pathological type, T stage, primary tumour size, existence beyond the midline of the nasopharynx at the primary site and parapharyngeal extension of the primary tumour were assessed regarding their impact on the laterality of LN metastasis using the x 2 test. Results: Of the 167 patients, 149 (89%) showed nodal involvement. The existence beyond the midline of the nasopharynx was significantly associated with the laterality of LN metastasis (p,0.0001). Most patients (82%) with primary tumour presence within the midline showed only ipsilateral LN metastasis or no LN metastasis. In addition, contralateral LN metastases were seen only at Level II and the retropharyngeal LN among most of other patients. Conclusion: These results suggest that LN areas other than Level II and the retropharyngeal LN on the contralateral side could be omitted in patients with primary tumour presence within the midline and without the contralateral Level II or the retropharyngeal LN. Whether disease control is compromised by reducing the radiation field for subclinical diseases is a problem that should be solved in the future by prospective study.

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Section: Nodal Metastasis In Nasopharyngeal Cancersupporting

confidence: 79%

Factors associated with nodal metastasis in nasopharyngeal cancer: an approach to reduce the radiation field in selected patients

Tomita

Fuwa²,

Ariji³

et al. 2011

BJR

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“…IMRT is now widely used in clinical practice and has shown clinical beneWt in patients with head-and-neck cancer. IMRT provides a means to spare the parotid glands, thereby avoiding the side eVect of late xerostomia and improving the patients' quality of life (Kodaira et al 2009;Huang et al 2008). With the inherent ability of IMRT to spare the surrounding normal tissues, it is imperative to determine whether there is a compromise in locoregional control.…”

Section: Discussionmentioning

confidence: 99%

Long-term follow-up and a detailed prognostic analysis of patients with oropharyngeal cancer treated with radiotherapy

Tomita

Kodaira

Furutani

et al. 2009

J Cancer Res Clin Oncol

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“…12 Volumetricmodulated arc therapy, a form of rotational IMRT, and stereotactic RT, a form of highly focused irradiation using tridimensional tumor targeting, also offer advantages. 13 Arc therapy reduces IMRT delivery time from 20 minutes to fewer than 5 minutes, while optimizing dose homogeneity and normal tissue sparing, [14][15][16][17][18][19][20][21][22][23][24][25] including parotid gland sparing. 26 Stereotactic fractionated RT allows for the generation of x-ray beams from a single electronic source, which can be rotated or moved around a central focus.…”

Section: Chemoradiation Therapymentioning

confidence: 99%

Oral complications of cancer and cancer therapy

Epstein

Thariat

Bensadoun

et al. 2012

CA A Cancer J Clinicians

431

356

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Answer questions and earn CME/CNEOral complications resulting from cancer and cancer therapies cause acute and late toxicities that may be underreported, underrecognized, and undertreated. Recent advances in cancer treatment have led to changes in the incidence, nature, and severity of oral complications. As the number of survivors increases, it is becoming increasingly recognized that the aggressive management of oral toxicities is needed to ensure optimal long‐term oral health and general well‐being. Advances in care have had an impact on previously recognized oral complications and are leading to newly recognized adverse effects. Here, the authors briefly review advances in cancer therapy, including recent advances in surgery, oral care, radiation therapy, hematopoietic cell transplantation, and medical oncology; describe how these advances affect oral health; and discuss the frequent and/or severe oral health complications associated with cancer and cancer treatment and their effect upon long‐term health. Although some of the acute oral toxicities of cancer therapies may be reduced, they remain essentially unavoidable. The significant impact of long‐term complications requires increased awareness and recognition to promote prevention and appropriate intervention. It is therefore important for the primary oncologist to be aware of these complications so that appropriate measures can be implemented in a timely manner. Prevention and management is best provided via multidisciplinary health care teams, which must be integrated and communicate effectively in order to provide the best patient care in a coordinated manner at the appropriate time. CA Cancer J Clin 2012. © 2012 American Cancer Society.

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Aichi Cancer Center Initial Experience of Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer Using Helical Tomotherapy

Cited by 32 publications

References 22 publications

Factors associated with nodal metastasis in nasopharyngeal cancer: an approach to reduce the radiation field in selected patients

Factors associated with nodal metastasis in nasopharyngeal cancer: an approach to reduce the radiation field in selected patients

Long-term follow-up and a detailed prognostic analysis of patients with oropharyngeal cancer treated with radiotherapy

Oral complications of cancer and cancer therapy

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