AIDS Complicated by Syphilis Can Mimick Uveitis and Crohn's Disease

Kleiner, Robert C.; Najarian, Lawrence; Levenson, Jeffrey; Kaplan, Henry J.

doi:10.1001/archopht.1987.01060110032016

Cited by 20 publications

(2 citation statements)

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“…(4) Syphilitic uveitis as leading symptom in secondary syphilis [32], (5) Syphilitic retrobulbar neuritis with blindness in both eyes [33], (6) Iridocyclitis with optic atrophy and concomitant (HIV-induced) ulcerous proctitis mis taken as morbus Crohn. Diagnosis of syphilitic uveitis was made after examination of the cerebrospinal fluid and correct interpretation of the skin lesions [34]. (7) Syphilitic retrobulbar neuritis with unilateral blind ness [35].…”

Section: Clinical Formssupporting

confidence: 41%

Syphilis and HIV Infection

Rufli

1989

Dermatology

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Treponema pallidum and HIV are both sexually transmitted agents of infectious diseases with epidemiological similarities. Ulcerous genital diseases such as primary syphilis facilitate transmission of HIV. An increasing number of case reports gives evidence that in HIV-infected patients secondary syphilis runs a more severe course and may present as syphilis maligna and that neurological complications of secondary and tertiary syphilis seem to occur more frequently and at an earlier stage. The clinical evaluation, interpretation of serology and choice of treatment schedules must take these considerations into account.

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Section: Clinical Formssupporting

confidence: 41%

Syphilis and HIV Infection

Rufli

1989

Dermatology

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“…One hundred and forty‐three original descriptions of patients with syphilitic uveitis were identified. These cases were identified in 41 different papers 2,6,7,9–11,14,17–52 …”

Section: Resultsmentioning

confidence: 99%

Syphilitic uveitis: a review of clinical manifestations and treatment outcomes of syphilitic uveitis in human immunodeficiency virus‐positive and negative patients

Amaratunge

Camuglia

Hall

2010

Clinical Exper Ophthalmology

136

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The incidence of syphilis and syphilitic uveitis in our community is increasing. The prevalence of associated neurosyphilis is unknown, and it remains unclear whether syphilitic uveitis should be treated as secondary syphilis with intramuscular penicillin or neurosyphilis with intravenous penicillin. The (English language) literature was reviewed for all unique cases of syphilitic uveitis reported from 1984 to June 2008. For each case the following data were recorded: the clinical features of the syphilis, the uveitis and any associated neurosyphilis, the human immunodeficiency virus (HIV) status, lumbar puncture findings, treatment and follow up. We identified 143 patients in 41 original reports of syphilitic uveitis (93 HIV-positive and 50 HIV-negative). Posterior uveitis was reported in 79 patients (55.2%); panuveitis was reported in 36 patients (25.2%); anterior/intermediate uveitis was reported in only 28 patients (19.6%). Lumbar puncture findings were abnormal in 82 patients (57%), and the majority of these patients (76%, 62 out of 82) were HIV-positive. One hundred and ten (77%) patients were treated with intravenous therapy, usually penicillin. Most recovered from the syphilis, however, a proportion did not recover full vision. There were 13 (9%) treatment failures, which tended to occur in patients who were HIV-positive (n = 11), had abnormal lumbar puncture findings (n = 8) and/or were treated (n = 11) intravenously. There is a high incidence of abnormal lumbar puncture findings in patients with syphilitic uveitis and a strong association with HIV infection. Most received appropriate therapy with a low relapse rate, which was not related to the type of therapy.

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