AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel

Chen, Chao; Song, Zhegang; Zheng, Xiaoyan; He, Zikai; Liu, Bin; Huang, Xuhui; Kong, Deling; Ding, Dan; Tang, Ben Zhong

doi:10.1039/c6sc03859j

Cited by 102 publications

(69 citation statements)

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“…[ 58 ] Interestingly, most AIE photosensitizers are activated by visible or ultraviolet (UV) irradiation. [ 59 ] NIR is converted into visible or UV light by UCNPs. Since NIR irradiation can penetrate tissues to higher depths, these UCNPs can be used as noninvasive PDT agents.…”

Section: Strategies For Targeting the Tmementioning

confidence: 99%

Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

et al. 2020

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Tailoring personalized cancer nanomedicines demands detailed understanding of the tumor microenvironment. In recent years, smart upconversion nanoparticles with the ability to exploit the unique characteristics of the tumor microenvironment for precise targeting have been designed. To activate upconversion nanoparticles, various bio‐physicochemical characteristics of the tumor microenvironment, namely, acidic pH, redox reactants, and hypoxia, are exploited. Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. Detailed understanding of the tumor microenvironment and the personalized design of upconversion nanoparticles will result in more effective clinical translation.

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Section: Strategies For Targeting the Tmementioning

confidence: 99%

Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

et al. 2020

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“…Aiming to enhance the therapeutic efficiency of drugs, adjuvants have been widely employed in CHT. Tang and Ding's groups 123 reported for the first time an AIE-active adjuvant named TPE-Py-FFGYSA, which was composed of a TPE fragment, FFG tripeptide and a peptide sequence YSAYPDSVPMMS (YSA) ( Figure 25 ). The FFG unit does not only play a role as a linker between TPE and YSA, but is also capable of promoting the AIE performance of TPE-Py-FFGYSA as well, resulting from more efficient restriction of intramolecular motions (RIM) thanks to the existence of an aromatic capping group in FFG.…”

Section: Recent Developmentmentioning

confidence: 99%

Theranostics based on AIEgens

Wang

Lee²,

Wei³

et al. 2018

Theranostics

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The utilization of luminogens with aggregation-induced emission (AIE) characteristics has recently been developed at a tremendous pace in the area of theranostics, mainly because AIE luminogens (AIEgens) hold various distinct advantages, such as good biocompatibility, excellent fluorescence properties, simple preparation and modification, perfect size of nano-aggregation for enhanced permeability and retention effect, promoted efficiencies of photodynamic and photothermal therapies, efficient photoacoustic imaging, and ready constructions of multimodal imaging and therapy. Significant breakthroughs and developments of theranostics based on AIEgens have been achieved in the past few years, and great progress has been witnessed in many theranostic modalities, indicating that AIEgens remarkably complement conventional theranostic materials and promote the development of theranostics. This review provides theoretical insights into the advantages of AIEgens in theranostics, and systematically summarizes the basic concepts, seminal studies, recent trends and perspectives in theranostics based on AIEgens. We believe that AIEgens would be promising multifunctional theranostic platforms in clinical fields and facilitate significant advancements in this research-active area.

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“…This work suggests a new research direction that a photosensitizer can serve as a nontoxic adjuvant to amplify the antitumor efficacy of radiotherapy. The same groups also demonstrated that using AIE adjuvant as a photosensitizer can amplify the antitumor efficacy of paclitaxel with an IC 50 value of 7.8 × 10 −9 m , which is only 10.3% of that of paclitaxel alone …”

Section: Cellular Imaging and Theranosticsmentioning

confidence: 94%

Unity Makes Strength: How Aggregation‐Induced Emission Luminogens Advance the Biomedical Field

et al. 2018

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research fields to provide new opportunities for precise and personalized medical treatment of patients. [16][17][18][19][20][21][22][23][24][25][26][27] An ideal fluorescent agent should have low toxicity, high brightness, excellent stability, good selectivity, and versatile functionality. To date, a vast variety of synthetic fluorescent materials, including organic dyes, [28][29][30] fluorescent proteins, [31,32] inorganic quantum dots (QDs), [33,34] conjugated polymer nanoparticles (NPs), [35][36][37][38][39][40] metallic nanoclusters, [41] as well as upconversion NPs, [42][43][44] have been explored and demonstrated for biological applications.Among the above-mentioned fluorescent materials, synthetic organic dyes and dye-loaded fluorescent NPs have attracted special attention due to the good biocompatibility and easy availability. However, a considerable number of organic dyes are hydrophobic, which often form aggregation through π-π stacking in aqueous solutions and buffers even though different strategies have been applied to improve their water solubility. The serious π-π stacking interactions among dye molecules facilitate nonradiative pathways to relax the exciton energy, leading to partially or completely quenched fluorescence. This phenomenon is well known as aggregation-caused quenching (ACQ) effect, [45] which is the main obstacle of construction of highly emissive fluorescence bioprobes in complicated biological microenvironments. Although great efforts have been made from various aspects to overcome the notorious undesired ACQ effect, [46] it remains a major challenge for the significant improvement of traditional fluorescent bioprobes in biomedicine and life sciences.In 2001, Tang and co-workers discovered a novel fluorescent phenomenon that is opposite to the ACQ effect: the organic Figure 4. Confocal images of Hela cancer cells after incubation with A-D) A6-A9 (5 × 10 −6 m) for 15 min, respectively. Adapted with permission. [104]

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AIEgen-based theranostic system: targeted imaging of cancer cells and adjuvant amplification of antitumor efficacy of paclitaxel

Abstract: An AIEgen-based theranostic system is developed to amplify the antitumor efficacy of paclitaxel with a synergistic effect of “0 + 1 > 1”.

Cited by 102 publications

References 50 publications

Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment

Theranostics based on AIEgens

Unity Makes Strength: How Aggregation‐Induced Emission Luminogens Advance the Biomedical Field

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