AIEgens for microbial detection and antimicrobial therapy

Bai, Haotian; He, Wei; Chau, Joseph Lik Hang; Zhang, Zheng; Kwok, Ryan T. K.; Lam, Jacky W. Y.; Tang, Ben Zhong

doi:10.1016/j.biomaterials.2020.120598

Cited by 104 publications

(76 citation statements)

References 71 publications

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“…The incubation time of up to 20 min allowed TPA‐DT‐Py to pass through the outermost phospholipid membrane to the middle peptidoglycan layer. [ 37 ] Unfortunately, MTPA‐DT‐Qy could neither stain S. aureus nor E. coli , likely due to its own weaker aggregate luminescence (Figure S50, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Molecular Engineering of Efficient Singlet Oxygen Generators with Near‐Infrared AIE Features for Mitochondrial Targeted Photodynamic Therapy

Yuan

Liang

et al. 2021

Adv Funct Materials

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Aggregation‐caused fluorescence quenching with insufficient production of reactive oxygen species (ROS) has limited the application of photosensitizers (PSs) in fluorescence‐imaging‐guided photodynamic therapy (PDT). Aggregation‐induced emission PSs (AIE‐PSs) exhibit enhanced fluorescence intensity and a high efficiency of ROS generation in the aggregation state, which provides an opportunity to solve the above problems. Herein, a series of AIE‐PSs are successfully designed and synthesized by adjusting the D–A intensity through molecular engineering. The photophysical properties and theoretical calculations prove that the synergistic effect of 3,4‐ethylenedioxythiophene and quinolinium increases the intramolecular charge transfer effect (ICT) of the whole molecule and promotes the intersystem crossing (ISC) from the lowest excited singlet state (S1) to the lowest triplet state (T1). Among these AIE‐PSs, the optimal AIE‐PS (TPA‐DT‐Qy) exhibits the highest generation yield of 1O2 (5.3‐fold of Rose Bengal). Further PDT experiments show that the TPA‐DT‐Qy has a highly efficient photodynamic ablation of breast cancer cells (MCF‐7 and MDA‐MB‐231) under white light irradiation. Moreover, the photodynamic antibacterial study indicates that TPA‐DT‐Qy has the discrimination and excellent photodynamic inactivation of S. aureus. This work provides a feasible strategy for the molecular engineering of novel AIE‐PSs to improve the development of fluorescence‐imaging‐guided PDT.

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Section: Resultsmentioning

confidence: 99%

Molecular Engineering of Efficient Singlet Oxygen Generators with Near‐Infrared AIE Features for Mitochondrial Targeted Photodynamic Therapy

Yuan

Liang

et al. 2021

Adv Funct Materials

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“…Among all the organic PSs that have been reported, PSs with aggregation-induced emission (AIE) characteristics have attracted increasing attention since some AIE-active PSs were demonstrated to exhibit a unique aggregation-induced enhancement of ROS [ 28 , 29 ]. So far, AIE-active PSs have been successfully developed for microbe detection, discrimination, and infection treatment [ [30] , [31] , [32] , [33] , [34] ]. Other than that, by precise molecular design in terms of adjusting the π-conjugation system and engineering the electron donor-acceptor moiety, AIE luminogens (AIEgens) with wide color tunability in the visible light range could be obtained, allowing for a white light-driven biocidal effect [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

AIEgen-loaded nanofibrous membrane as photodynamic/photothermal antimicrobial surface for sunlight-triggered bioprotection

Wen

et al. 2021

Biomaterials

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The outbreak of infectious diseases such as COVID-19 causes an urgent need for abundant personal protective equipment (PPE) which leads to a huge shortage of raw materials. Additionally, the inappropriate disposal and sterilization of PPE may result in a high risk of cross-contamination. Therefore, the exploration of antimicrobial materials possessing both microbe interception and self-decontamination effects to develop reusable and easy-to-sterilize PPE is of great importance. Herein, an aggregation-induced emission (AIE)-active luminogen-loaded nanofibrous membrane (TTVB@NM) sharing sunlight-triggered photodynamic/photothermal anti-pathogen functions are prepared using the electrospinning technique. Thanks to its porous nanostructure, TTVB@NM shows excellent interception effects toward ultrafine particles and pathogenic aerosols. Benefiting from the superior photophysical properties of the AIE-active dopants, TTVB@NM exhibits integrated properties of wide absorption in visible light range, efficient ROS generation, and moderate photothermal conversion performance. A series of antimicrobial evaluations reveal that TTVB@NM could effectively inactivate pathogenic aerosols containing bacteria (inhibition rate: >99%), fungi (~88%), and viruses (>99%) within only 10 min sunlight irradiation. This study represents a new strategy to construct reusable and easy-to-sterilize hybrid materials for potential bioprotective applications.

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“…[ 27 , 28 ] PSs with aggregation‐induced emission (AIE) properties have recently become powerful tools for PDT of bacteria, fungi, and tumor. [ 21 , 24 , 26 , 29 ] These PSs are usually featured with propeller‐shaped molecular conformations, and show not only enhanced FL but also elevated ROS sensitizing efficiency in the aggregated or solid‐state, as compared to that in the discrete molecular state. Despite the successful applications of AIEgen for PDT of bacteria, fungi, and tumor, research on PDI of the virus has been seldom reported.…”

Section: Introductionmentioning

confidence: 99%

A Membrane‐Targeting Photosensitizer with Aggregation‐Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human Coronaviruses

Leung

et al. 2021

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COVID‐19 pandemic, caused by severe acute respiratory syndrome coronavirus 2, has resulted in global social and economic disruption, putting the world economy to the largest global recession since the Great Depression. To control the spread of COVID‐19, cutting off the transmission route is a critical step. In this work, the efficient inactivation of human coronavirus with photodynamic therapy (PDT) by employing photosensitizers with aggregation‐induced emission characteristics (DTTPB) is reported. DTTPB is designed to bear a hydrophilic head and two hydrophobic tails, mimicking the structure of phospholipids on biological membranes. DTTPB demonstrates a broad absorption band covering the whole visible light range and high molar absorptivity, as well as excellent reactive oxygen species sensitizing ability, making it an excellent candidate for PDT. Besides, DTTPB can target membrane structure, and bind to the envelope of human coronaviruses. Upon light irradiation, DTTPB demonstrates highly effective antiviral behavior: human coronavirus treated with DTTPB and white‐light irradiation can be efficiently inactivated with complete loss of infectivity, as revealed by the significant decrease of virus RNA and proteins in host cells. Thus, DTTPB sensitized PDT can efficiently prevent the infection and the spread of human coronavirus, which provides a new avenue for photodynamic combating of COVID‐19.

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AIEgens for microbial detection and antimicrobial therapy

Cited by 104 publications

References 71 publications

Molecular Engineering of Efficient Singlet Oxygen Generators with Near‐Infrared AIE Features for Mitochondrial Targeted Photodynamic Therapy

Molecular Engineering of Efficient Singlet Oxygen Generators with Near‐Infrared AIE Features for Mitochondrial Targeted Photodynamic Therapy

AIEgen-loaded nanofibrous membrane as photodynamic/photothermal antimicrobial surface for sunlight-triggered bioprotection

A Membrane‐Targeting Photosensitizer with Aggregation‐Induced Emission Characteristics for Highly Efficient Photodynamic Combat of Human Coronaviruses

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