Ailanthone inhibits non-small cell lung cancer cell growth through repressing DNA replication via downregulating RPA1

Ni, Zhongya; Yao, Chao; Zhu, Xiaowen; Gong, Chenyuan; Xu, Zihang; Wang, Lixin; Li, Suyun; C, Zou; Zhu, Shuchai

doi:10.1038/bjc.2017.319

Cited by 43 publications

(52 citation statements)

References 25 publications

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“…Considering the potential acute and chronic effects of YTE‐17, the safety of YTE‐17 was also observed in AOM/DSS mice after gavaged with YTE‐17 for 12 weeks (Supporting Figure S5). Consistent with the results in the Ni's report, 54 no signs of damage of liver lobule and renal tubular epithelial cells in both group of the mice.…”

Section: Discussionsupporting

confidence: 92%

The active fraction of Garcinia yunnanensis suppresses the progression of colorectal carcinoma by interfering with tumorassociated macrophage‐associated M2 macrophage polarization in vivo and in vitro

Sui

Tan

et al. 2020

FASEB j.

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Colorectal cancer (CRC) is the third most common solid tumor worldwide and has shown resistance to several immunotherapies, particularly immune checkpoint blockade therapy, which is effective in many other types of cancer. Our previous studies indicated that the active fraction of Garcinia yunnanensis (YTE‐17), had potent anticancer activities by regulating multiple signaling pathways. However, knowledge regarding the mechanism and effect of YTE‐17 in the prevention of CRC is limited. This study tested the effects of YTE‐17 on colon cancer development in vivo by using two murine models: the carcigenic azoxymethane/dextran sulfate sodium (AOM/DSS)‐induced CRC model and a genetically induced model using ApcMin/+ mice. Here, the tumor load, tumor number, histology, and even some oncogenes were used to evaluate the effect of YTE‐17. The intragastric administration of YTE‐17 for 12 weeks significantly decreased CRC incidence, tumor number and size, immunity, and some tumor‐associated macrophage (TAM) markers, including CD206, Arg‐1, IL‐10, and TGF‐β. Importantly, the macrophages depletion by clodronate (CEL) also played a role in reducing the tumor burden and inhibiting tumor development, which were not affected by YTE‐17 in the ApcMin/+ mice. Moreover, the YTE‐17 treatment attenuated CRC cell growth in a co‐culture system in the presence of macrophages. Consistently, YTE‐17 effectively reduced the tumor burden and macrophage infiltration and enhanced immunity in the AOM/DSS and ApcMin/+ colon tumor models. Altogether, we demonstrate that macrophages in the microenvironment may contribute to the development and progression of CRC cells and propose YTE‐17 as a new potential drug option for the treatment of CRC.

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Section: Discussionsupporting

confidence: 92%

The active fraction of Garcinia yunnanensis suppresses the progression of colorectal carcinoma by interfering with tumorassociated macrophage‐associated M2 macrophage polarization in vivo and in vitro

Sui

Tan

et al. 2020

FASEB j.

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“…Oxidative stress-induced neuronal damage is critical for the development of ischemic stroke [1]. Ischemic stroke is a devastating disease and has been considered as the predominant cause of mortality and chronic disability worldwide [2].…”

Section: Introductionmentioning

confidence: 99%

Scutellaria barbata D. Don (SBD) protects oxygen glucose deprivation/reperfusion-induced injuries of PC12 cells by up-regulating Nrf2

Wang

Li²,

Zhang³

2019

Artificial Cells, Nanomedicine, and Biotechnology

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This study aimed to investigate the potential effect of Scutellaria barbata D. Don (SBD) on oxygen glucose deprivation/reperfusion (OGD/R)-injured PC12 cells. PC12 cells were pretreated with various concentrations of 0.1-0.8 mg/ml SBD for indicated times (12-48 h) and then subjected to OGD/R injury. Cell viability, apoptosis and proliferation were detected using MTT assay, flow cytometry, Ki67 staining and western blot. Oxidative damage was assessed by detecting MDA content, SOD activity and GSH levels. The mitochondrial membrane potential (Dwm) was measured by Rh123 staining. Western blot was performed to assess the expression levels of Nrf2 and PI3K/AKT pathway-related proteins. We found that SBD pretreatment promoted cell viability and proliferation but inhibited apoptosis of OGD/R-injured PC12 cells in dosage-and time-dependent manner. Meanwhile, SBD attenuated oxidative damage and restored mitochondria dysfunction, as evidenced by the reduced MDA content, the increased SOD and GSH levels, and the increased Dwm. Furthermore, SBD induced the expression of Nrf2 in a PI3K/AKT-dependent signalling. Knockdown of Nrf2 blocked the protective effects of SBD on PC12 cells. In conclusion, this study demonstrates that SBD pretreatment protects PC12 cells against OGD/R-induced injury. The potential mechanism may be through up-regulating the expression of Nrf2 in a PI3K/AKT-dependent pathway. ARTICLE HISTORY

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“…Macheret et al indicated that the enhancement of DNA replication is an important symbol of cancer progression ( 50 ). A recent study revealed that ailanthone can suppress NSCLC growth by restraining DNA replication through reducing RPA1 (replication protein A1) ( 51 ). In our research, the prediction signature was not only connected with the immune response but also with tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

A Seven Immune-Related lncRNAs Model to Increase the Predicted Value of Lung Adenocarcinoma

Liu

et al. 2020

Front. Oncol.

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Background Recent research has shown that immune-related lncRNA plays a crucial part in the tumor immune microenvironment. This study tried to identify immune-related lncRNAs and construct a robust prediction model to increase the predicted value of lung adenocarcinoma (LUAD). Methods RNA expression data of LUAD were download from the Cancer Genome Atlas (TCGA) database. Immune genes were acquired from the Molecular Signatures Database (MSigDB). The immune gene related lncRNAs were acquired by the “limma R” package and Cytoscape3.7.1. Cox regression analysis was applied to construct this forecast model. The prognostic model was validated by the testing cohort which was acquired by the bootstrap method. Results A total of 551 lncRNA expression profiles including 497 LUAD tissues and 54 non-LUAD tissues were obtained. A total of 331 immune genes were acquired. The result of the Cox regression analysis showed that seven lncRNAs (AC022784-1, NKILA, AC026355-1, AC068338-3, LINC01843, SYNPR-AS1, and AC123595-1) can be performed to construct the prediction model to forecast the prognosis of LUAD. Kaplan–Meier curves indicated that our prediction model can distribute LUAD patients into two different risk groups (high and low) with significant statistical significance ( P = 1.484e-07). Cox analysis and independent analysis illustrated that the seven-lncRNAs prediction model was an isolated factor by comparing it with other clinical variables. We validated the accuracy of our model in the testing dataset. Furthermore, the prognostic model also showed higher predictive efficiency than three other published prognostic models. The two different survival groups represented diverse immune features according to principal components analysis. GSEA analysis (gene set enrichment analysis) indicated that seven-lncRNAs signatures may be involved in the progression of tumorigenesis. Conclusions We have established a seven immune-related lncRNAs prediction model. This prognostic model had significant clinical significance that increased the predicted value and guided the personalized treatment for LUAD patients.

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Ailanthone inhibits non-small cell lung cancer cell growth through repressing DNA replication via downregulating RPA1

Cited by 43 publications

References 25 publications

The active fraction of Garcinia yunnanensis suppresses the progression of colorectal carcinoma by interfering with tumorassociated macrophage‐associated M2 macrophage polarization in vivo and in vitro

The active fraction of Garcinia yunnanensis suppresses the progression of colorectal carcinoma by interfering with tumorassociated macrophage‐associated M2 macrophage polarization in vivo and in vitro

Scutellaria barbata D. Don (SBD) protects oxygen glucose deprivation/reperfusion-induced injuries of PC12 cells by up-regulating Nrf2

A Seven Immune-Related lncRNAs Model to Increase the Predicted Value of Lung Adenocarcinoma

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