Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis

Onoda, Hideko; Kimura, Tokuhiro; Tao, Hiroyuki; Okabe, Kazunori; Matsumoto, Tsuneo; Ikeda, Eiji

doi:10.1111/1759-7714.12638

Cited by 9 publications

(8 citation statements)

References 16 publications

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“…In our study, air bronchogram was not found to be significantly correlated with OS or PFS; however, previous studies (20,21) have suggested that it could be an independent prognostic factor for other malignancies. Onoda et al (20) found that air bronchogram was a favorable prognostic factor for pulmonary pleomorphic carcinoma. They speculated that air bronchogram may indicate a less aggressive tumor, as it shows that the intratumoral bronchi have remained intact, without destruction by tumor invasion or expansion.…”

Section: Discussioncontrasting

confidence: 97%

The characteristic computed tomography findings of pulmonary B-cell non-Hodgkin’s lymphoma and their role in predicting patient survival

Wang¹,

Pan²,

Zhu³

et al. 2021

Quant Imaging Med Surg

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Background: To assess the value of characteristic computed tomography (CT) findings in predicting the survival of patients with pulmonary B-cell non-Hodgkin's lymphoma (NHL).Methods: Eighty-four patients who were histopathologically confirmed with pulmonary B-cell NHL between 2004 and 2018 were retrospectively enrolled. All patients underwent chest CT scan at the time of initial diagnosis in our hospital. Characteristic CT findings and clinicopathological features of the patients were analyzed, and Cox regression models were used to determine the relationship of CT findings with overall survival (OS) and progression-free survival (PFS).Results: Air bronchogram occurred more frequently in patients with early-stage disease, primary pulmonary lymphoma (PPL) and the indolent histological type of lymphoma than in patients with advancedstage disease, secondary pulmonary lymphoma (SPL), and the aggressive histological type (all P<0.05). The halo sign was observed most in the SPL group (19/48, 40%; P=0.004), while the presence of cross-lobe sign was higher in patients with PPL (13/36, 36%; P=0.010). Pleural involvement and hilar/mediastinal lymphadenopathy were observed more in patients with SPL and the aggressive histological type (33/48 and 27/48; 31/46 and 26/46, respectively; all P<0.05). Survival analyses showed that the number of lung lesions, cross-lobe sign, and pleural involvement were independent prognostic factors for PFS, while the halo sign and pleural involvement were significantly correlated with OS (all P<0.05). More aggressive, advanced-stage cases and male patients showed worse outcomes. Conclusions:The halo sign and pleural involvement are independent prognostic factors for OS, while the number of lung lesions, cross-lobe sign, and pleural involvement are correlated with PFS.

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Section: Discussioncontrasting

confidence: 97%

The characteristic computed tomography findings of pulmonary B-cell non-Hodgkin’s lymphoma and their role in predicting patient survival

Wang¹,

Pan²,

Zhu³

et al. 2021

Quant Imaging Med Surg

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“…Therefore, we believe that patients with type III or IV are more likely to benefit from targeted therapy. Some research has indicated that GGO and air bronchogram, which are closely related to the lepidic predominant subtype, are significant risk factors of EGFR mutation in the context of solitary lung cancer; 7,[22][23][24][29][30][31] this may be a good explanation to our results. Considering that most patients with type II and VII do not carry EGFR mutations, standard chemotherapy is still the first-line treatment strategy and targeted therapy can be offered to patients with EGFR mutations.…”

supporting

confidence: 65%

Computed Tomography Morphological Classification of Lung Adenocarcinoma and Its Correlation with Epidermal Growth Factor Receptor Mutation Status: A Report of 1075 Cases

Li¹,

He²,

Fan³

et al. 2021

IJGM

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Background: Many delayed diagnoses of lung adenocarcinoma (LADC) are identified due to poor understanding of protean imaging findings. Moreover, clarifying the relationship between computed tomography (CT) morphological classification and epidermal growth factor receptor (EGFR) mutations of LADC might inform therapeutic decision-making while obtaining pathological specimens is difficult. Here, we retrospectively analyzed CT manifestations of LADC and investigated the morphological classification of tumors in relation to EGFR mutation status. Methods: We included 1075 LADC patients undergoing chest CT and EGFR genotype examinations from January 2013 to January 2019. CT morphological characteristics of tumors were carefully evaluated and their correlation with EGFR mutation status was analyzed using the chi-squared test. Results: Tumors were divided into eight types: I (peripheral solid nodule/mass; 526/1075, 48.93%), II (central solid nodule/mass; 220/1075, 20.47%), III (subsolid nodule/mass; 92/1075, 8.56%), IV (focal consolidation; 32/1075, 2.98%), V (cystic airspace; 14/1075, 1.30%), VI (multiple lesions with similar appearances to I-V; 85/1075, 7.91%), VII (diffuse consolidation; 53/1075, 4.93%), VIII (occult lesion usually obscured by nonobstructive atelectasis; 53/1075, 4.93%). Type III and IV tumors were more frequent in patients with EGFR mutation, whereas type II and VII tumors were more common in patients without EGFR mutation (all P < 0.05). However, we did not identify any significant associations between other tumor types and EGFR mutation status (all P > 0.05). Among patients with type VI tumors, EGFR mutation status was closely related to tumor density (all P < 0.05). Furthermore, type VII tumors were associated with 19 deletion mutation positive and non-L858R mutation positive (all P < 0.05). Conclusion:LADC can be categorized into eight types based on CT imaging. Improving our understanding of the morphological classification and correlation with EGFR mutation status may contribute to the accurate diagnosis of LADC, while suggesting the presence of underlying EGFR genetic mutations.

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“…Pathological massive coagulation necrosis indicates aggressive tumor growth, thereby contributing to poor prognosis [ 8 ]. On the contrary, air bronchogram on CT was suggested to be a favorable prognostic factor, which might reflect intact intratumoral bronchi without tumor invasion [ 16 ]. In addition to the cavity in the tumor, tumor size, and pleural invasion, our study showed for the first time that ringed FDG uptake on PET/CT was a significant prognostic factor of PPC.…”

Section: Discussionmentioning

confidence: 99%

Ringed fluorodeoxyglucose uptake predicted poor prognosis after resection of pulmonary pleomorphic carcinoma

Shishido

Aoyama

Hara

et al. 2022

J Cardiothorac Surg

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Background Pulmonary pleomorphic carcinoma (PPC) is a relatively rare and poorly differentiated non-small cell carcinoma. This study aimed to investigate the clinicopathological features including programmed cell death ligand 1 (PD-L1) expression status in patients with PPC who underwent curative resection. Methods We retrospectively studied 29 consecutive patients who had undergone anatomical lung resections for PPC. Perioperative and pathological variables, including radiological findings, were investigated to define prognostic factors. Results Overall survival (OS) rates were 71.8% at 1 year and 60.0% at 5 years. Disease-free survival (DFS) rates were 54.8% at 1 year and 43.6% at 5 years. Univariate analysis revealed that ringed fluorodeoxyglucose (FDG) uptake on positron emission tomography/computed tomography (PET/CT) (p = 0.003), a cavity in the tumor on CT (p = 0.004), and tumor size (> 40 mm) (p = 0.014) were poor prognostic factors for OS. Regarding DFS, ringed FDG uptake (p = 0.002), a cavity on CT (p < 0.001), tumor size (p = 0.007), and pleural invasion (p = 0.014) were poor prognostic factors. PD-L1 expression was not a prognostic factor. Conclusion This study showed for the first time that ringed FDG uptake on PET/CT is a poor prognostic factor of PPC. PD-L1 expression status was not related to the prognosis. Trial registration The study was approved by the Kobe City Medical Center General Hospital’s ethics board (No. 20112) on August 20, 2020.

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Air bronchogram in pleomorphic carcinoma of the lung is associated with favorable prognosis

Cited by 9 publications

References 16 publications

The characteristic computed tomography findings of pulmonary B-cell non-Hodgkin’s lymphoma and their role in predicting patient survival

The characteristic computed tomography findings of pulmonary B-cell non-Hodgkin’s lymphoma and their role in predicting patient survival

Computed Tomography Morphological Classification of Lung Adenocarcinoma and Its Correlation with Epidermal Growth Factor Receptor Mutation Status: A Report of 1075 Cases

Ringed fluorodeoxyglucose uptake predicted poor prognosis after resection of pulmonary pleomorphic carcinoma

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