Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips

Schulze, Frank; Gao, Xinghua; Viržonis, Darius; Damiati, Samar; Schneider, Marlon R.; Kodzius, Rimantas

doi:10.3390/genes8100244

Cited by 94 publications

(57 citation statements)

References 146 publications

(175 reference statements)

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“…The large surface area of PM 2.5 contributes to the combination of toxic compounds, including polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), and transition metals [ 4 , 5 ]. PM 2.5 can be inhaled into the gas exchange area of human lungs [ 6 , 7 ] where the ultrafine component is released to the systemic circulatory system, causing damage to cells and tissues [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

Cho

Hsieh

Tsai

et al. 2018

IJERPH

157

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Air pollution is a very critical issue worldwide, particularly in developing countries. Particulate matter (PM) is a type of air pollution that comprises a heterogeneous mixture of different particle sizes and chemical compositions. There are various sources of fine PM (PM2.5), and the components may also have different effects on people. The pathogenesis of PM2.5 in several diseases remains to be clarified. There is a long history of epidemiological research on PM2.5 in several diseases. Numerous studies show that PM2.5 can induce a variety of chronic diseases, such as respiratory system damage, cardiovascular dysfunction, and diabetes mellitus. However, the epidemiological evidence associated with potential mechanisms in the progression of diseases need to be proved precisely through in vitro and in vivo investigations. Suggested mechanisms of PM2.5 that lead to adverse effects and chronic diseases include increasing oxidative stress, inflammatory responses, and genotoxicity. The aim of this review is to provide a brief overview of in vitro and in vivo experimental studies of PM2.5 in the progression of various diseases from the last decade. The summarized research results could provide clear information about the mechanisms and progression of PM2.5-induced disease.

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Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

Cho

Hsieh

Tsai

et al. 2018

IJERPH

157

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“…Finally, despite that the degree of computer science does not include specific subjects related to sustainable energy sources or climate change and sustainable development, students and graduates are able to develop multiple applications related with environment protection. In collaboration with Nicolas Boccard professor of the Economics Faculty, students of computer science have developed an application for air quality detection [21]. Fig.…”

Section: B Collaborations With Public and Private Institutionsmentioning

confidence: 99%

Sustainable Energies as an Educational Challenge: Regarding Engineering Studies at the University of Girona

González¹,

Pacheco²,

Luo³

et al. 2024

RE&PQJ

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Education is a keyword when environmental sustainability and climate change mitigation are pursued. It is a global objective that affect all the World, so social and technological universities are engaged with the aim of mitigating the change and improving the necessary adaptation. From the technical school of the University of Girona, our educational framework, consisting of a set of degrees with just some subject related with sustainable energies, is introduced. This work overpasses teaching activity within the university walls because contacts with local entities and the research of productive wind energy lands are also reported. Private and public contacts are both described, the problem is a social issue that focuses on the public interest but also a business opportunity for the private companies.

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“…Lung-on-a-chip devices are widely used to examine the toxicity of several nanoparticles and to understand the pulmonary diseases resulting from blockage of the small airways due to liquid plug formation that prevents gas flow in alveoli [ 156 ]. Oxygen transfer efficiency and fluid mechanical resistance are two critical parameters that must be taken into consideration during the design of the human lung [ 157 ].…”

Section: Application Of Microfluidics For Protein Synthesis and Drmentioning

confidence: 99%

Microfluidic Devices for Drug Delivery Systems and Drug Screening

Damiati

Kompella

Kodzius

2018

Genes

Self Cite

296

199

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Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology enables the generation of highly stable, uniform, monodispersed particles with higher encapsulation efficiency. Since the existing preclinical models are inefficient drug screens for predicting clinical outcomes, microfluidic platforms might offer a more rapid and cost-effective alternative. Compared to 2D cell culture systems and in vivo animal models, microfluidic 3D platforms mimic the in vivo cell systems in a simple, inexpensive manner, which allows high throughput and multiplexed drug screening at the cell, organ, and whole-body levels. In this review, the generation of appropriate drug or gene carriers including different particle types using different configurations of microfluidic devices is highlighted. Additionally, this paper discusses the emergence of fabricated microfluidic cell-free protein synthesis systems for potential use at point of care as well as cell-, organ-, and human-on-a-chip models as smart, sensitive, and reproducible platforms, allowing the investigation of the effects of drugs under conditions imitating the biological system.

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Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips

Cited by 94 publications

References 146 publications

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

In Vitro and In Vivo Experimental Studies of PM2.5 on Disease Progression

Sustainable Energies as an Educational Challenge: Regarding Engineering Studies at the University of Girona

Microfluidic Devices for Drug Delivery Systems and Drug Screening

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