Air temperature variability and high-sensitivity C reactive protein in a general population of China

Kang, Yuting; Tang, Haosu; Jiang, Linlin; Wang, Su; Wang, Xin; Chen, Zuo; Zhang, Linfeng; Zheng, Congyi; Wang, Zengwu; Huang, Gang; Gao, Runlin; investigators, China Cvd study

doi:10.1016/j.scitotenv.2020.141588

Cited by 26 publications

(13 citation statements)

References 35 publications

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“…Also, other established inflammatory markers were not measured in our study to confirm their course. Furthermore, smoking 32) and weather 33) during hospital stay and operation day as CRP-influencing factors were not investigated. The treatment with anti-inflammatory drugs and immune modulatory drugs was also not investigated but rheumatoid disease was excluded from the study.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in Serum C-Reactive Protein Course after Total Hip Arthroplasty

Rohe

Röhner

Windisch³

et al. 2022

Clin Orthop Surg

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Background Gender-specific medicine has become an important part in investigating the course of various diseases. C-reactive protein (CRP) is used as an inflammatory marker for detecting inflammations and even infections after total hip arthroplasty (THA). The general course of CRP after THA is well known, but there is controversy about its association with sex. Therefore, we aimed to investigate if there is an influence of sex on the CRP after THA in the first 10 days after operation in a complication-free course in male and female patients and to re-evaluate the specific postoperative CRP course with its maximum on the second to third postoperative days. Methods We retrospectively reviewed patients who had been treated with THA due to primary osteoarthritis through the same approach using an equal model of a cementless stem and a cup and complication-free between 2013 and 2016. Patients with active inflammation, rheumatoid arthritis, secondary arthrosis, active cancer disease, and documented postoperative complications were not included. The CRP values before THA and up to 10 days after THA were recorded and tested for sex discrepancy. Factor analyses were performed, and CRP values were adjusted for confounders (age, operation time, diabetes mellitus, and body mass index [BMI]). Results A total of 1,255 patients (728 women and 527 men) were finally analyzed. Men were younger and had a longer operation time and a higher BMI compared to women. The prevalence of overweight was higher in men, while obesity (BMI > 40 kg/m 2 ), diabetes mellitus, renal failure, and American Society of Anaesthesiologists status showed no significant difference between men and women. Men had significantly higher CRP values than women between the 2nd and the 7th postoperative days, with the largest difference on the 4th postoperative day (men, 130.48 mg/L; women, 87.26 mg/L; p = 0.018). Conclusions Based on the results of more precise sex-specific evaluation of the postoperative CRP course after THA, the present study showed for the first time that there was a gender discrepancy in the CRP course after complication-free THA in the first 7 postoperative days. Furthermore, this study confirmed the postoperative CRP course with its maximum on the third postoperative day.

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Section: Discussionmentioning

confidence: 99%

Sex Differences in Serum C-Reactive Protein Course after Total Hip Arthroplasty

Rohe

Röhner

Windisch³

et al. 2022

Clin Orthop Surg

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“…In addition, the levels of hs-CRP are not only elevated by urate-stimulated inflammation, but are also affected by age, gender and various health status-related factors, such as comorbidities. 44 45 Thus, surrogate biomarkers would need to be determined more specifically to reflect urate activity and changes in urate activity with SU-lowering therapies.…”

Section: Discussionmentioning

confidence: 99%

Association between serum urate level and carotid atherosclerosis: an insight from a post hoc analysis of the PRIZE randomised clinical trial

et al. 2022

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ObjectivesElevated serum urate (SU) levels are associated with arterial atherosclerosis and subsequent cardiovascular events. However, an optimal therapeutic target SU level for delaying atherosclerotic progression in patients with hyperuricaemia remains uncertain. The aim of this analysis was to assess an association between changes in SU level and carotid intima–media thickness (IMT) to examine whether an optimal SU concentration exists to delay atherosclerotic progression.MethodsThis was a post hoc analysis of the PRIZE (programme of vascular evaluation under uric acid control by xanthine oxidase inhibitor, febuxostat: multicentre, randomised controlled) study of Japanese adults with asymptomatic hyperuricaemia. The primary endpoint of this analysis was an association between changes in SU levels and mean common carotid artery IMT (CCA-IMT) after 24 months of febuxostat treatment.ResultsAmong subjects treated with febuxostat (n=239), a total of 204 who had both data on SU and mean CCA-IMT at baseline and 24 months were included in this analysis. The mean baseline SU level was 7.7±1.0 mg/dL, and febuxostat treatment significantly reduced SU concentrations at 24 months (estimated mean change ‒3.051 mg/dL, 95% CI ‒3.221 to ‒2.882). A multivariable linear regression analysis revealed that a reduction in SU level was associated with changes in mean CCA-IMT values at 24 months (p=0.025). In contrast, the achieved SU concentrations were not associated with changes in mean CCA-IMT at 24 months.ConclusionA greater reduction in SU, but not its achieved concentrations, may be associated with delayed progression of carotid IMT in patients with asymptomatic hyperuricaemia treated with febuxostat.Trial registration numberUMIN000012911

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“…The potential biological mechanisms of the association between TV and CVD/ CED YLL rates are not fully understood. Kang et al found that short-term exposures to TV significantly increased the level of high-sensitivity C reactive protein among 11,623 Chinese people, which is an important circulating biomarker of systemic inflammation, and is related to a series of adverse cardiovascular events [41]. In addition, TV may affect heart rate variability by autonomic nervous system [42,43], which will further increase the risk of cardiovascular mortality [44].…”

Section: Discussionmentioning

confidence: 99%

Mortality burden attributable to temperature variability in China

Gong

Zhou

et al. 2022

J Expo Sci Environ Epidemiol

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BACKGROUND: Several studies have investigated the associations between temperature variability (TV) and death counts. However, evidence of TV-attributable years of life lost (YLL) is scarce. OBJECTIVES: To investigate the associations between TV and YLL rates (/100,000 population), and quantify average life loss per death (LLD) caused by TV in China. METHODS: We calculated daily YLL rates (/100,000 population) of non-accidental causes and cardiorespiratory diseases by using death data from 364 counties of China during 2006-2017, and collected meteorological data during the same period. A distributed lag non-linear model (DLNM) and multivariate meta-analysis were used to estimate the effects of TV at national or regional levels. Then, we calculated the LLD to quantify the mortality burden of TV. RESULTS: U-shaped curves were observed in the associations of YLL rates with TV in China. The minimum YLL TV (MYTV) was 2.5 °C nationwide. An average of 0.89 LLD was attributable to TV in total, most of which was from high TV (0.86, 95% CI: 0.56, 1.16). However, TV caused more LLD in the young (<65 years old) (1.87, 95% CI: 1.03, 2.71) than 65-74 years old (0.85, 95% CI: 0.40-1.31) and ≥75 years old (0.40, 95% CI: 0.21-0.59), cerebrovascular disease (0.74, 95% CI: 0.36, 1.11) than respiratory disease (0.54, 95% CI: 0.21, 0.87), South (1.23, 95% CI: 0.77, 1.68) than North (0.41, 95% CI: −0.7, 1.52) and Central China (0.40, 95% CI: −0.02, 0.81). TVattributed LLD was modified by annual mean temperature, annual mean relative humidity, altitude, latitude, longitude, and education attainment. SIGNIFICANCE: Our findings indicate that high and low TVs are both associated with increases in premature death, however the majority of LLD was attributable to high TV. TV-related LLD was modified by county level characteristics. TV should be considered in planning adaptation to climate change or variability. IMPACT:(1) We estimated the associations of TV with YLL rates, and quantified the life loss per death (LLD) caused by TV.(2) An average of 0.89 years of LLD were attributable to TV, most of which were from high TVs.(3) TV caused more LLD in the young, cerebrovascular disease, and southern China. (4) The mortality burdens were modified by county level characteristics.

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Air temperature variability and high-sensitivity C reactive protein in a general population of China

Cited by 26 publications

References 35 publications

Sex Differences in Serum C-Reactive Protein Course after Total Hip Arthroplasty

Sex Differences in Serum C-Reactive Protein Course after Total Hip Arthroplasty

Association between serum urate level and carotid atherosclerosis: an insight from a post hoc analysis of the PRIZE randomised clinical trial

Mortality burden attributable to temperature variability in China

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