Airborne pollutants as potential triggers of systemic autoimmune rheumatic diseases: a narrative review

Celen, Hannelore; Dens, Anne‐Catherine; Ronsmans, Steven; Langhe, Ellen De; Michiels, Stijn

doi:10.1080/17843286.2021.1992582

Cited by 9 publications

(10 citation statements)

References 58 publications

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“…The studies included in this review are from Italy [ 13 ], Egypt [ 14 , 15 , 16 ], Unites States [ 17 , 18 ], Mexico [ 19 , 20 , 21 , 22 ], Sweden [ 23 , 24 ], China [ 25 , 26 , 27 ], Turkey [ 28 ], and Finland [ 29 ]. One study was multicentered [ 14 ].…”

Section: Resultsmentioning

confidence: 99%

“…The inflammatory mediators stimulate the maturation of macrophages in APCs. When joint macrophages are transformed into APCs, these cells have major opportunities to break up autoimmunity control and present self-antigens of joints to T cells, which migrate to articular structures and cause inflammation, leading to RA [ 5 , 26 , 27 , 31 , 32 ].…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

“…Additionally, LAG-3+ regulatory T cells were in lower levels in the serum of RA patients that presented high disease activity than in healthy subjects. Due to these attributions, FGL1 can be used as a possible intervention target in treating RA with different disease activities [ 26 , 139 , 140 , 141 ].…”

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

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Organokines in Rheumatoid Arthritis: A Critical Review

Laurindo

Maio

Barbalho

et al. 2022

IJMS

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Rheumatoid arthritis (RA) is a systemic autoimmune disease that primarily affects the joints. Organokines can produce beneficial or harmful effects in this condition. Among RA patients, organokines have been associated with increased inflammation and cartilage degradation due to augmented cytokines and metalloproteinases production, respectively. This study aimed to perform a review to investigate the role of adipokines, osteokines, myokines, and hepatokines on RA progression. PubMed, Embase, Google Scholar, and Cochrane were searched, and 18 studies were selected, comprising more than 17,000 RA patients. Changes in the pattern of organokines secretion were identified, and these could directly or indirectly contribute to aggravating RA, promoting articular alterations, and predicting the disease activity. In addition, organokines have been implicated in higher radiographic damage, immune dysregulation, and angiogenesis. These can also act as RA potent regulators of cells proliferation, differentiation, and apoptosis, controlling osteoclasts, chondrocytes, and fibroblasts as well as immune cells chemotaxis to RA sites. Although much is already known, much more is still unknown, principally about the roles of organokines in the occurrence of RA extra-articular manifestations.

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Section: Resultsmentioning

confidence: 99%

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

Section: General Aspects Of Ra and The Role Of Myokines Osteokines Ad...mentioning

confidence: 99%

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Organokines in Rheumatoid Arthritis: A Critical Review

Laurindo

Maio

Barbalho

et al. 2022

IJMS

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“…Suspected drivers of SADs include internal and external exposures throughout life, interacting with genetic predispositions 6,7 . Pathogen infection is believed to play a pivotal role in the development of SADs 8 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of serum Epstein–Barr virus envelope glycoproteins antibodies and their association with systemic autoimmune diseases

Li,

Zhong,

Kang

et al. 2024

Journal of Medical Virology

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Systemic autoimmune diseases (SADs) are a growing spectrum of autoimmune disorders that commonly affect multiple organs. The role of Epstein–Barr virus (EBV) infection or reactivation as a trigger for the initiation and progression of SADs has been established, while the relationship between EBV envelope glycoproteins and SADs remains unclear. Here, we assessed the levels of IgG, IgA, and IgM against EBV glycoproteins (including gp350, gp42, gHgL, and gB) in serum samples obtained from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and found that RA and SLE patients exhibited a statistically significant increase in the levels of 8 and 11 glycoprotein antibodies, respectively, compared to healthy controls (p < 0.05). The LASSO model identified four factors as significant diagnostic markers for RA: gp350 IgG, gp350 IgA, gHgL IgM, and gp42 IgA; whereas for SLE it included gp350 IgG, gp350 IgA, gHgL IgA, and gp42 IgM. Combining these selected biomarkers yielded an area under the curve (AUC) of 0.749 for RA and 0.843 for SLE. We subsequently quantified the levels of autoantibodies associated with SADs in mouse sera following immunization with gp350. Remarkably, none of the tested autoantibody levels exhibited statistically significant alterations. Elevation of glycoprotein antibody concentration suggests that Epstein–Barr virus reactivation and replication occurred in SADs patients, potentially serving as a promising biomarker for diagnosing SADs. Moreover, the absence of cross‐reactivity between gp350 antibodies and SADs‐associated autoantigens indicates the safety profile of a vaccine based on gp350 antigen.

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“…Genetic predisposition accounts for approximately 30% of autoimmune diseases; environmental factors including air pollution are also involved the development of these diseases ( 3 , 4 ). Ambient air pollution levels have been reported to have acute adverse effects on population health, primarily in terms of respiratory and cardiovascular conditions ( 5 , 6 ); their role in autoimmune diseases has gained attention in recent years ( 7 ). Environmental exposure to air pollution may mediate the development of autoimmune diseases by increasing inflammatory responses, oxidative stress, and immune responses.…”

Section: Introductionmentioning

confidence: 99%

Exposure to particulate pollutant increases the risk of hospitalizations for Sjögren’s syndrome

et al. 2022

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ObjectiveNumerous researches have reported the role of air pollution in the development of autoimmune diseases. However, few have evaluated the relationship between inhalable particulate matter (PM) exposure and Sjögren’s syndrome (SS). This study aimed to analyze the association between exposure to two particulate pollutants (PM2.5, PM10) and SS-related hospitalizations.MethodsDaily data were obtained on PM2.5 and PM10, meteorological factors, and hospital hospitalizations for SS between 2016 and 2021. The daily data on PM2.5 and PM10, meteorological factors, and the number of SS hospitalizations were collected between 2016 and 2021. A distributed lag non-linear model and a generalized linear model were established to explore the association between PM2.5 and PM10 exposure and hospitalizations for SS. Stratified analyses were performed to explore possible gender-, age-, and season-related differences in PM2.5 and PM10 effects.ResultsExposure to PM2.5 was related to the evaluated risk of hospitalizations for SS (RR=1.015, 95% CI: 1.001-1.029, lag 3 day), similarly, PM10 exposure had a statistically significant positive association with SS hospitalizations (RR =1.013, 95% CI: 1.001-1.026, lag 3 day). Stratified analyses found that exposure to PM2.5 and PM10 exhibited higher impact on SS-related hospitalizations in female patients and exposure to PM2.5 was also associated with the higher risk of SS-related hospitalizations in patients aged ≥ 65 years. In addition, exposure to PM2.5, PM10 in colder season were more likely to increase SS-related hospitalizations.ConclusionOur findings suggested that exposure to PM2.5 and PM10 were significantly linked to an elevated risk of hospitalizations for SS.

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Airborne pollutants as potential triggers of systemic autoimmune rheumatic diseases: a narrative review

Cited by 9 publications

References 58 publications

Organokines in Rheumatoid Arthritis: A Critical Review

Organokines in Rheumatoid Arthritis: A Critical Review

Evaluation of serum Epstein–Barr virus envelope glycoproteins antibodies and their association with systemic autoimmune diseases

Exposure to particulate pollutant increases the risk of hospitalizations for Sjögren’s syndrome

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