Airflow Limitation Is Accompanied by Diaphragm Dysfunction

Hellebrandová, Lenka; Chlumský, J; Vostatek, Pavel; Novák, Daniel; Rýznarová, Z; Bunc, Václav

doi:10.33549/physiolres.933064

Cited by 33 publications

(22 citation statements)

References 34 publications

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“…COPD patients experience decreased FEV 1 progressively every year by 50 to 60 ml [16,17]. As in our study the %FEV 1 value decreased in both groups.…”

Section: Discussionsupporting

confidence: 68%

The Effects of Allopurinol on Glutathione Sulfhydryl (GSH) Serum Level, %FEV1, Six Minute Walking Test, and CAT Score of Chronis Obstructive Pulmonary Disease Patients

Sutanto¹,

Suradi²,

Samuel³

2019

KLS

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“…COPD patients experience decreased FEV 1 progressively every year by 50 to 60 ml [16,17]. As in our study the %FEV 1 value decreased in both groups.…”

Section: Discussionsupporting

confidence: 68%

The Effects of Allopurinol on Glutathione Sulfhydryl (GSH) Serum Level, %FEV1, Six Minute Walking Test, and CAT Score of Chronis Obstructive Pulmonary Disease Patients

Sutanto¹,

Suradi²,

Samuel³

2019

KLS

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“…viruses or allergens), would lead to a vicious cycle of hypersensitive responses (Song and Chang 2015). There is also progress in the identification of various signalling pathways (Hellebrandová et al 2016) involved in the sensitization of the TRP channels by pro-inflammatory agents (Kádková et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Cough Reflex Sensitivity in Asthmatic Children

Kunč

Fabry²,

Lucanska³

et al. 2020

Physiol Res

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New knowledge about the neural aspects of cough has revealed a complex network of pathways that initiate cough. The effect of inflammation on cough neural processing occurs at multiple peripheral and central sites within the nervous system. Evidence exists that direct or indirect neuroimmune interaction induces a complex response, which can be altered by mediators released by the sensory or parasympathetic neurons and vice versa. The aim of this study was to clarify changes of cough reflex sensitivity – the activity of airway afferent nerve endings - in asthmatic children. 25 children with asthma and 15 controls were submitted to cough reflex sensitivity measurement - capsaicin aerosol in doubling concentrations (from 0.61 to 1250 µmol/l) was inhaled by a single breath method. Concentrations of capsaicin causing two (C2) and five coughs (C5) were reported. Asthmatic children' (11 boys and 14 girls, mean age 9 ± 1 yrs) cough reflex sensitivity (geometric mean, with the 95 % CI) for C2 was 4.25 (2.25-8.03) µmol/l vs. control C2 (6 boys and 9 girls, mean age 8 ± 1 yrs) was 10.61 (5.28-21.32) µmol/l (p=0.024). Asthmatic children' C5 was 100.27 (49.30-203.93) µmol/l vs. control C5 56.53 (19.69-162.35) µmol/l (p=0.348). There was a statistically significant decrease of C2 (cough threshold) in the asthmatic patients relative to controls (p-value for the two-sample t-test of log(C2) for the one-sided alternative, p-value = 0.024). The 95 % confidence interval for the difference of the mean C2 in asthma vs. control, [1.004, 6.207]. For C5, the difference was not statistically significant (p-value = 0.348). There was a statistically significant decrease of cough reflex sensitivity (the activity of airway afferent nerve endings) - C2 value in the asthmatic children relative to controls.

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“…Another important advantage of chest MRI over chest CT is that it allows us to acquire simultaneous information on lung structure and function without using ionising radiation. This opens up new ways to study lung mechanics in asthmatic subjects [59].…”

Section: Radio Ga Gamentioning

confidence: 99%

Paediatric lung imaging: the times they are a-changin'

et al. 2018

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Until recently, functional tests were the most important tools for the diagnosis and monitoring of lung diseases in the paediatric population. Chest imaging has gained considerable importance for paediatric pulmonology as a diagnostic and monitoring tool to evaluate lung structure over the past decade. Since January 2016, a large number of papers have been published on innovations in chest computed tomography (CT) and/or magnetic resonance imaging (MRI) technology, acquisition techniques, image analysis strategies and their application in different disease areas. Together, these papers underline the importance and potential of chest imaging and image analysis for today's paediatric pulmonology practice. The focus of this review is chest CT and MRI, as these are, and will be, the modalities that will be increasingly used by most practices. Special attention is given to standardisation of image acquisition, image analysis and novel applications in chest MRI. The publications discussed underline the need for the paediatric pulmonology community to implement and integrate state-of-the-art imaging and image analysis modalities into their structure-function laboratory for the benefit of their patients.

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Airflow Limitation Is Accompanied by Diaphragm Dysfunction

Cited by 33 publications

References 34 publications

The Effects of Allopurinol on Glutathione Sulfhydryl (GSH) Serum Level, %FEV1, Six Minute Walking Test, and CAT Score of Chronis Obstructive Pulmonary Disease Patients

The Effects of Allopurinol on Glutathione Sulfhydryl (GSH) Serum Level, %FEV1, Six Minute Walking Test, and CAT Score of Chronis Obstructive Pulmonary Disease Patients

Cough Reflex Sensitivity in Asthmatic Children

Paediatric lung imaging: the times they are a-changin'

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