Airway hyperresponsiveness correlates with airway TSLP in asthma independent of eosinophilic inflammation

Andreasson, Louise Munkholm; Dyhre-Petersen, Nanna; Hvidtfeldt, Morten; Jørgensen, Gustav Ørting; Von Bülow, Anna; Klein, Ditte Kjærsgaard; Uller, Lena; Erjefält, Jonas; Porsbjerg, Celeste; Sverrild, Asger

doi:10.1016/j.jaci.2023.11.915

Cited by 6 publications

(1 citation statement)

References 34 publications

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“…Studies investigating the role of TSLP in asthma demonstrate a correlation, indicating elevated serum levels of TSLP in asthmatic patients compared to healthy individuals. The authors also discuss associations with male gender, increasing age, and eosinophilia, which are suggested to be linked with higher concentrations of TSLP in the blood [22]. Similarly, in children, higher concentrations of TSLP have been revealed in patients with asthma, but no significant differences were found when dividing the asthmatic group into allergic and non-allergic individuals.…”

Section: Discussionmentioning

confidence: 95%

Exploring TSLP and IL-33 Serum Levels and Genetic Variants: Unveiling Their Limited Potential as Biomarkers for Mild Asthma in Children

Połomska,

Sikorska-Szaflik,

Drabik-Chamerska

et al. 2024

JCM

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As the burden of mild asthma is not well understood, the significance of expanding research in the group of patients with mild asthma is emphasized. Thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL-33) are involved in the pathogenesis of atopy and the immune response to inhaled environmental insults, such as allergens, in asthmatic patients. Objectives: The objective of this study was to explore the correlation between specific polymorphisms within the genes encoding TSLP and IL-33, as well as the concentrations of TSLP and IL-33 in the serum, and the occurrence of pediatric mild asthma. Methods: The analysis encompassed 52 pediatric patients diagnosed with mild bronchial asthma, including both atopic and non-atopic cases, and a control group of 26 non-asthmatic children. Recruitment was conducted through a comprehensive questionnaire. Parameters such as allergic sensitization, serum levels of circulating TSLP and IL-33, and the identification of single-nucleotide polymorphisms in TSLP (rs11466750 and rs2289277) and IL-33 (rs992969 and rs1888909) were assessed for all participants. Results: Significantly lower mean serum TSLP concentrations were observed in asthmatic subjects compared to the control group, with atopic asthma patients showing even lower TSLP levels than non-atopic counterparts. No significant differences were found in mean serum IL-33 concentrations between the two groups. Considering the allele model, for both tested SNPs of IL-33, we observed that patients with asthma, atopic asthma, and atopy statistically less frequently possess the risk allele. Conclusions: Our study findings suggest that IL-33 and TSLP do not serve as ideal biomarkers for mild asthma in children. Their effectiveness as biomarkers might be more relevant for assessing disease severity rather than identifying asthma in pediatric patients. Further research focusing on the association between TSLP and IL-33 gene polymorphisms and asthma is expected to significantly advance disease management.

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Section: Discussionmentioning

confidence: 95%