Airway Obstruction Correlates with Collagenase-2 (MMP-8) Expression and Activation in Bronchial Asthma

Prikk, Kaiu; Maisi, Päivi; Pirilä, Emma; Reintam, Mari-Ann; Salo, Tuula; Sorsa, Timo; Sepper, Ruth

doi:10.1097/01.lab.0000035023.53893.b6

Cited by 105 publications

(123 citation statements)

References 48 publications

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…In the same compartment, the concentrations of free soluble MMP-8 and -9 and neutrophil-specific human neutrophil lipocalin are all increased in tobacco smokers with subclinical emphysema [42]. In addition, the intracellular level of MMP-8 tends to be higher in patients with severe asthma than in those with mildto-moderate asthma [86]. Furthermore, the local concentration or activity of MMP-9 is increased in patients with asthma after allergen challenge, and MMP-9 mediates allergen-induced nonspecific hyperresponsiveness in sensitised mouse airways in vivo; these observations are fully in line with this particular proteinase having a functional impact [84,[87][88][89].…”

Section: Matrix Metalloproteinasesmentioning

confidence: 78%

Neutrophils, interleukin-17A and lung disease

Lindén¹

2005

Eur Respir J

221

182

View full text Add to dashboard Cite

It is now established that an excessive and sustained mobilisation of neutrophils is a hallmark of several chronic inflammatory lung disorders, including severe obstructive lung disease. This article reviews evidence that the cytokine interleukin (IL)-17A is a major orchestrator of sustained neutrophilic mobilisation.Current evidence suggests that IL-17A is produced by T-lymphocytes, and that it exerts an orchestrating effect on the accumulation and associated activity of neutrophils in the bronchoalveolar space indirectly, through an induced release of specific cytokines and colonystimulating factors in resident lung cells.Although the involvement of IL-17A in inflammatory lung disorders is supported by several recent studies, its causative role is still uncertain.However, the unique position of interleukin-17A at the interface between acquired and innate immunity puts this cytokine forward as an important signal for the reinforcement of host defence; it also implies that interleukin-17A may constitute a useful target for pharmacotherapeutic intervention.

show abstract

Section: Matrix Metalloproteinasesmentioning

confidence: 78%

Neutrophils, interleukin-17A and lung disease

Lindén¹

2005

Eur Respir J

221

182

View full text Add to dashboard Cite

show abstract

“…Besides MMP-9 production, neutrophils also produce MMP-8 that is stored in their secondary granules and released upon stimulation. An increase of MMP-8 expression has been reported in bronchial biopsies and in bronchoalveolar lavage from asthmatic patients suggesting that this enzyme could play an important role in this disease (Cataldo et al, 2001;Prikk et al, 2002). To verify this hypothesis, we recently applied a mouse model of asthma to MMP-8 deficient mice (MMP-8 KO) and we found surprisingly that mice lacking MMP-8 displayed a severe granulocytic inflammation in airways after allergen exposure .…”

Section: Implication Of Mmps In the Pathogenesis Of Asthmamentioning

confidence: 99%

Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases

Guéders

Foidart

Noël

et al. 2006

European Journal of Pharmacology

279

224

View full text Add to dashboard Cite

In healthy lung, Matrix Metalloproteinases (MMPs) and their physiological inhibitors, tissue inhibitors of matrix metalloproteinases (TIMPs), are produced in the respiratory tract by a panel of different structural cells. These activities are mandatory for many physiological processes including development, wound healing and cell trafficking. Deregulation of proteolytic-antiproteolytic network and inappropriate secretion of various MMPs by stimulated structural or inflammatory cells is thought to take part to pathophysiology of numerous lung diseases including asthma, chronic obstructive pulmonary disease (COPD), lung fibrosis and lung cancer. Cytokines and growth factors are involved in these inflammatory processes and some of those mediators interact directly with MMPs and TIMPs leading either to a regulation of their expression or changes in their biological activities by proteolytic cleavage. In turn, cytokines and growth factors modulate secretion of MMPs establishing a complex network of reciprocal interactions. Every MMP seem to play a rather specific role and some variations of their expression are observed in different lung diseases. The precise role of these enzymes and their inhibitors is now studied in depth as they could represent relevant therapeutic targets for many diseases. Indeed, MMP inhibition can lead either to a decrease of the intensity of a pathological process or, in the contrary for some of them, to an increase of disease severity. In this review, we focus on the role played by MMPs and TIMPs in asthma and we provide an overview of their potential roles in COPD, lung fibrosis and lung cancer, with a special emphasis on loops including MMPs and cytokines and growth factors relevant in these diseases.Keywords: Matrix metalloproteinase; Tissue inhibitor of MMP; Asthma; Cytokine; Growth factors Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs)Matrix metalloproteinases (MMPs), or matrixins, belong to the metzincin superfamily of metalloproteinases, also including astacins, ADAMs (a protein with a disintegrin and metallopro-tease domain) and ADAM-TS proteases (ADAM with a thrombospondin-like motif) (Sternlicht and Werb, 2001;Folgueras et al., 2004;Handsley and Edwards, 2005;Noel et al., 2004). MMPs are proteolytic enzymes believed to be implicated in many physiological and pathological processes including embryonic development, morphogenesis, reproductive processes, bone remodeling, wound healing, cancer, arthritis, atherosclerosis, MMPs are zinc and calciumdependent enzymes being able to degrade virtually all extracellular matrix components. This can modulate cell behaviour by creating influential cellular environment (Shapiro, 1998). The extracellular matrix is a complex network of molecules including collagens, fibronectin, laminin, entactin/ nidogen and heparan sulfate proteoglycans (Mott and Werb, 2004). The extracellular matrix is a mechanical support for cells but also acts as a reservoir for cytokines and growth factors (vascular endothelial ...

show abstract

“…Diseases of the respiratory system. Clinical data from asthma patients suggest that levels of activated MMP-8 in bronchoalveolar lavage fluid (BALF) are an indicator of disease severity and are correlated with airway obstruction (Prikk et al, 2002). Also, MMP-8-deficient mice developed more severe inflammation than wild type mice in an allergen-induced airway inflammation model and showed more neutrophils in the bronchoalveolar lavage fluid (Gueders et al, 2005).…”

Section: Neoplastic Diseasesmentioning

confidence: 99%

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Sbardella

Fasciglione

Gioia

et al. 2012

Molecular Aspects of Medicine

210

212

View full text Add to dashboard Cite

a b s t r a c tHuman matrix metalloproteinases (MMPs) belong to the M10 family of the MA clan of endopeptidases. They are ubiquitarian enzymes, structurally characterized by an active site where a Zn 2+ atom, coordinated by three histidines, plays the catalytic role, assisted by a glutamic acid as a general base. Various MMPs display different domain composition, which is very important for macromolecular substrates recognition. Substrate specificity is very different among MMPs, being often associated to their cellular compartmentalization and/or cellular type where they are expressed. An extensive review of the different MMPs structural and functional features is integrated with their pathological role in several types of diseases, spanning from cancer to cardiovascular diseases and to neurodegeneration. It emerges a very complex and crucial role played by these enzymes in many physiological and pathological processes.

show abstract

Airway Obstruction Correlates with Collagenase-2 (MMP-8) Expression and Activation in Bronchial Asthma

Cited by 105 publications

References 48 publications

Neutrophils, interleukin-17A and lung disease

Neutrophils, interleukin-17A and lung disease

Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: Potential implications in asthma and other lung diseases

Human matrix metalloproteinases: An ubiquitarian class of enzymes involved in several pathological processes

Contact Info

Product

Resources

About