AL Amyloidosis: Unfolding a Complex Disease

Lu, Rebecca; Richards, Tiffany

doi:10.6004/jadpro.2019.10.8.4

Cited by 5 publications

(1 citation statement)

References 57 publications

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“…The deposition of amyloid may be localised, with the deposits occurring in a single organ/tissue or systemic where Frontiers in Biomaterials Science frontiersin.org numerous organs and tissues in the body are affected (Juneja and Pati, 2020). Amyloidosis can present with a broad range of nonspecific and unpredictably progressive symptoms depending on where the amyloid fibrils deposit (Chee et al, 2010;Lu and Richards, 2019). Evaluation of two independent cohorts of patients with light chain amyloidosis reveal a wide range of affected organs in a majority of patients (% of patients indicated), including heart (70%), kidney (60%), liver (20%), gastrointestinal (15%), peripheral (15%) or autonomic nervous system (10%), and soft tissue (10%) (Wechalekar et al, 2013;Muchtar et al, 2019).…”

Section: Amyloidosismentioning

confidence: 99%

Extracellular vesicles as next-generation therapeutics and biomarkers in amyloidosis: a new frontier

Phan,

Reed

2024

Front. Biomater. Sci.

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Nanoparticles hold a great potential for therapeutic targeting due to their ability to improve the stability of encapsulated cargo and promote the transport of cargo across membranes to reach to the target site. Most commercially available nanomedicines are simple synthetic liposomes, however, there are numerous side effects due to their off-target delivery and rapid clearance from the bloodstream. Recently, attention has moved toward extracellular vesicles (EVs)–lipid bilayer enclosed particles released by cells (size ranging from 30 to 10,000 nm in diameter). EVs carry and transport lipids, proteins, and nucleic acids from their parental cells to recipient cells, hence they play a key role in intercellular communication. The ability of EVs to cross biological barriers including the blood brain barrier has generated significant attention to explore them as potential biomarkers and natural drug delivery vehicles for various therapeutics and small molecules. EVs have also been implicated in disease pathogenesis by transmitting pathogenic proteins between cells, making them promising biomarkers for disease diagnosis and monitoring. In this review, we will focus on the potential and challenges of EVs as biomarkers, drug delivery vehicles and next-generation therapeutics. Finally, we will explore misfolded protein disorders, amyloidosis, as a case study for how EVs may contribute to disease pathology and how EVs could be applied in the clinic as diagnostic and prognostic biomarkers of amyloid diseases.

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Section: Amyloidosismentioning

confidence: 99%

Extracellular vesicles as next-generation therapeutics and biomarkers in amyloidosis: a new frontier

Phan,

Reed

2024

Front. Biomater. Sci.

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Retrolenticular Vitreous Opacities as a Diagnostic Indicator of Systemic Amyloidosis

Abramowitz

Chin

Almeida³

2022

Journal of VitreoRetinal Diseases

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Purpose: Systemic amyloidosis is a group of rare, life-threatening disorders characterized by the deposition of amyloid plaques in numerous tissues. Vitreous involvement can occur in amyloidosis and here we describe critical diagnostic findings. Methods: Case report of vitreous amyloidosis diagnosis confounded by non-specific presentation. Results: Despite false-negative vitreous biopsies, in the setting of previous vitreoretinal surgery, the case reveals vitreous opacities, decreased visual acuity, and retinal neovascularization as critical signs in ocular amyloidosis. Conclusions: Here we present the signs and symptoms that raise suspicion for vitreous amyloidosis and how to approach diagnosis early in the disease presentation.

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Persistent diarrhea with petechial rash - unusual pattern of light chain amyloidosis deposition on skin and gastrointestinal biopsies: A case report

Bilton¹,

Shah²,

Dougherty³

et al. 2022

World J Clin Cases

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AL Amyloidosis: Unfolding a Complex Disease

Cited by 5 publications

References 57 publications

Extracellular vesicles as next-generation therapeutics and biomarkers in amyloidosis: a new frontier

Extracellular vesicles as next-generation therapeutics and biomarkers in amyloidosis: a new frontier

Retrolenticular Vitreous Opacities as a Diagnostic Indicator of Systemic Amyloidosis

Persistent diarrhea with petechial rash - unusual pattern of light chain amyloidosis deposition on skin and gastrointestinal biopsies: A case report

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