Alantolactone suppresses APOC3 expression and alters lipid homeostasis in L02 liver cells

Serum apolipoprotein C3 levels are negatively associated with hepatitis B virus DNA in HBeAg-negative chronic hepatitis B patients

“…Some reports indicated that ApoC3 plays a central role in regulating the plasma metabolism of TG-rich lipoproteins (TRL), and decreases TRL hydrolysis [5, 10]. ApoC3 and ApoA5 are associated with multiple lipid metabolism-related diseases, such as type 1 diabetes and coronary artery disease [11–13]. Although previous study showed that HBV inhibits ApoA5 and ApoC3 promoter activity and mRNA and protein expression through its core gene [14] or X gene [15], respectively, little was revealed about the association between ApoC3 or ApoA5 and HBV replication rate in CHB patients.…”

MicroRNA‐424‐5p regulates aortic smooth muscle cell function in atherosclerosis by blocking APOC3‐mediated nuclear factor‐κB signalling pathway

“…The human APOCs are protein components of VLDL, chylomicrons and high‐density lipoprotein (Jong, Hofker, & Havekes, ). One study discovered that downregulation of APOC3 might alleviate lipid metabolism‐related diseases through the regulation of lipid (LDL) levels (Yang et al., ). Furthermore, loss‐of‐function mutations of APOC3 could also decrease the risk for developing clinical atherosclerotic cardiovascular diseases (Natarajan et al., ).…”

“…APOC3 is a component of very‐low‐density lipoprotein (VLDL) and an inhibitor of lipoprotein lipase, which modulates the binding of chylomicron remnants and VLDL to LDL receptors (Ginsberg & Brown, ; Valenti et al., ). APOC3 is also related to different lipid metabolism‐related diseases, including type 1 diabetes, non‐alcoholic fatty liver disease and various cardiovascular diseases, particularly AS (Yang et al., ). The silencing of APOC3 has been reported previously to result in the inhibition of the nuclear factor‐κB (NF‐κB) signalling pathway, providing protection for placental cells against oxidative stress‐induced injury and reducing the inflammatory response (Li, Wang, Liu, & Xu, ).…”

The potential role of sesquiterpene lactones isolated from medicinal plants in the treatment of the metabolic syndrome – A review

“…Serum creatinine and urea nitrogen levels (↓). Kim et al., 2017a , 2017b ; Yang et al., 2018 ; Zhu et al., 2020 7 Tirotundin 3,10-epoxygermacranolide Tithonia diversifolia Antidiabetic ( in vitro ) Dual PPARα/γ agonists Lin, 2012 8 Tagitinin A 9 Tagitinin G Anti-hyperglycemic ( in vitro ) Glucose uptake in 3T3-L1 adipocytes (↑). Zhao et al., 2012 10 Tagitinin I 11 1β-hydroxydiversifolin-3-O-methyl ether 12 1β-hydroxytirotundin-3-O-methyl ether 13 Micheliolide Guaianolide Magnolia compressa Anti-inflammatory- associated to diabetic nephropathy ( in vitro ) Anti-hepatic steatosis ( in vivo and in vitro ) Suppressed the glucose-stimulated degradation of IκBα and the subsequent activation of NF-κB in rat glomerular mesangial cells.…”

“…In this context, the compound 6 inhibits IL-6-induced insulin-stimulated glucose intolerance and insulin resistance in the skeletal muscle through blockade the activation of STAT3 and the abnormal expression of TLR4 ( Kim et al., 2017a , 2017b ). In L02 cells, alantolactone ( 6 ) also inhibits oxLDL-induced lipid accumulation trough regulating the apolipoprotein C3 (APOC3) expression partly by decreasing the activation of STAT3 ( Yang et al., 2018 ). Thus, may be relevant to explore further its role in managing metabolic complications on e.g.…”