Albumin-stabilized layered double hydroxide nanoparticles synergized combination chemotherapy for colorectal cancer treatment

Li, Li; Qian, Yujin; Sun, Luyao; Han, Felicity Y.; Zhang, Run; Wang, Peng‐Yuan; Xu, Zhi Ping

doi:10.1016/j.nano.2021.102369

Cited by 25 publications

(23 citation statements)

References 47 publications

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“…The loading efficiency of PTX-BSA on LIPC reached almost 100% with the loading capacity of 2.3%. Both loaded therapeutics were adequate for CRC treatment [ 26 ]. Note that the loading of ICG and PTX-BSA on LIPC could be adjustable more or less accordingly.…”

Section: Resultsmentioning

confidence: 99%

“…It is reported that PTX-BSA forms a 130-nm nanoparticle. However, PTX-BSA nanoparticles quickly disassembly into PTX-BSA molecules (⁓10 nm) at the concentration below 100 µg/mL [ 26 ]. These PTX-BSA molecules are supposed to adsorb onto the surface of LDH NSs, and their cellular uptake is facilitated by LDH NSs and further enhanced by CCM targeting, similarly to the ICG uptake by CT26 cells.…”

Section: Resultsmentioning

confidence: 99%

“…An equal volume of PTX-BSA solution (24 µg/mL, 10 wt % PTX in PTX-BSA) was slowly added to LI suspension (1 mg/mL) under vigorous stirring and the stirring was continued for 30 min based on our previous report [ 26 ]. Subsequently, the mixture was added to the equal volume of BSA (5 mg/mL) to obtain LIP.…”

Section: Methodsmentioning

confidence: 99%

“…By incorporating Mn 2+ or 19 F magnetic resonance imaging (MRI) probe into LDH NSs, we have developed the pH-sensitive MRI imaging platforms for specific detection of cancers [ 22 , 23 ]. On the other hand, LDH NSs improve the tumor accumulation for efficient chemotherapy and PTT [ 24 – 26 ]. Moreover, positively charged LDH NSs can electrostatically carry negatively charged drugs, siRNA, antigens, and CpG, for crossing the blood–brain barrier [ 27 ], gene delivery [ 28 ], and immunotherapy [ 19 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

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Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

et al. 2021

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Background Multi-modal therapy has attracted increasing attention as it provides enhanced effectiveness and potential stimulation of the immune community. However, low accumulation at the tumor sites and quick immune clearance of the anti-tumor agents are still insurmountable challenges. Hypothetically, cancer cell membrane (CCM) can homologously target the tumor whereas multi-modal therapy can complement the disadvantages of singular therapies. Meanwhile, moderate hyperthermia induced by photothermal therapy can boost the cellular uptake of therapeutic agents by cancer cells. Results CCM-cloaked indocyanine green (ICG)-incorporated and abraxane (PTX-BSA)-loaded layered double hydroxide (LDH) nanosheets (LIPC NSs) were fabricated for target efficient photo-chemotherapy of colorectal carcinoma (CRC). The CCM-cloaked LDH delivery system showed efficient homologous targeting and cytotoxicity, which was further enhanced under laser irradiation to synergize CRC apoptosis. On the other hand, CCM-cloaking remarkably reduced the uptake of LDH NSs by HEK 293T cells and macrophages, implying mitigation of the side effects and the immune clearance, respectively. In vivo data further exhibited that LIPC NSs enhanced the drug accumulation in tumor tissues and significantly retarded tumor progression under laser irradiation at very low therapeutic doses (1.2 and 0.6 mg/kg of ICG and PTX-BSA), without observed side effects on other organs. Conclusions This research has demonstrated that targeting delivery efficiency and immune-escaping ability of LIPC NSs are tremendously enhanced by CCM cloaking for efficient tumor accumulation and in situ generated hyperthermia boosts the uptake of LIPC NSs by cancer cells, a potential effective way to improve the multi-modal cancer therapy. Graphical Abstract

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

et al. 2021

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“…Combination chemotherapy using antineoplastic agents with a different mechanism of action is one potential approach used to combat cancer [ 1 ]. However, the significant drug resistance and narrow dosing window of these drugs, combined with a lack of selectivity, decrease the efficacy of cancer chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Cytotoxic Activity Study of Novel 2-(Aryldiazenyl)-3-methyl-1H-benzo[g]indole Derivatives

et al. 2021

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A novel series of 2-(aryldiazenyl)-3-methyl-1H-benzo[g]indole derivatives (3a–f) were prepared through the cyclization of the corresponding arylamidrazones, employing polyphosphoric acid (PPA) as a cyclizing agent. All of the compounds (3a–f) were characterized using 1H NMR, 13C NMR, MS, elemental analysis, and melting point techniques. The synthesized compounds were evaluated for cytotoxic activity against diverse human cancer cell lines by the National Cancer Institute. While all of the screened compounds were found to be cytotoxic at a 10 µM concentration, two of them (2c) and (3c) were subjected to five dose screens and showed a significant cytotoxicity and selectivity.

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Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

Li,

Soyhan,

Warszawik

et al. 2024

Advanced Science

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Layered double hydroxides (LDHs) have been widely studied for biomedical applications due to their excellent properties, such as good biocompatibility, degradability, interlayer ion exchangeability, high loading capacity, pH‐responsive release, and large specific surface area. Furthermore, the flexibility in the structural composition and ease of surface modification of LDHs makes it possible to develop specifically functionalized LDHs to meet the needs of different applications. In this review, the recent advances of LDHs for biomedical applications, which include LDH‐based drug delivery systems, LDHs for cancer diagnosis and therapy, tissue engineering, coatings, functional membranes, and biosensors, are comprehensively discussed. From these various biomedical research fields, it can be seen that there is great potential and possibility for the use of LDHs in biomedical applications. However, at the same time, it must be recognized that the actual clinical translation of LDHs is still very limited. Therefore, the current limitations of related research on LDHs are discussed by combining limited examples of actual clinical translation with requirements for clinical translation of biomaterials. Finally, an outlook on future research related to LDHs is provided.

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Albumin-stabilized layered double hydroxide nanoparticles synergized combination chemotherapy for colorectal cancer treatment

Cited by 25 publications

References 47 publications

Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

Biomimetic 2D layered double hydroxide nanocomposites for hyperthermia-facilitated homologous targeting cancer photo-chemotherapy

Synthesis and Cytotoxic Activity Study of Novel 2-(Aryldiazenyl)-3-methyl-1H-benzo[g]indole Derivatives

Layered Double Hydroxides: Recent Progress and Promising Perspectives Toward Biomedical Applications

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