Albuminuria is Suggested as a Potential Health Screening Biomarker for Senior Citizens and General Population with Hypertension or Diabetes in China

Gu, Danan; Xu, Pengcheng; Yuan, Yuhua; Fu, Hongwei

doi:10.7754/clin.lab.2016.160212

Cited by 2 publications

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“…The clinical test with the highest sensitivity and the best predictive value for an early diagnosis of DN is the measurement of albuminuria in urinary tests; measuring MAL is considered the ‘gold standard’. Although, clinically, MAL is used for an early diagnosis of DN, it is affected by a variety of factors, such as systemic or urinary tract infections, bleeding, vigorous exercise, or kidney damage related to drugs. Therefore, MAL alone cannot provide a timely and accurately diagnosis DN.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of serum interleukin‐8 and soluble tumor necrosis factor‐like weak inducer of apoptosis levels in patients with diabetic nephropathy

Liu

Chen

2018

J of Diabetes Invest

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Aims/IntroductionRecent studies suggest that chronic inflammatory responses are important in the development of diabetic nephropathy (DN). Various inflammatory and angiogenesis molecules affect the pathogenesis and progression of DN. Inflammation damages the microcirculation and causes kidney damage. In the present study, we studied changes in interleukin‐8 (IL‐8) and soluble tumor necrosis factor‐like weak inducer of apoptosis (sTWEAK) levels in patients with DN, and investigated the clinical significance of these two inflammatory factors.Materials and MethodsParticipants were categorized into healthy controls (n = 30) and patients with type 2 diabetes mellitus (n = 124). The type 2 diabetes mellitus group was further subdivided into the normoalbuminuria (n = 34), microalbuminuria (MAU ; n = 46,) and proteinuria (MaAU; n = 44,) groups. Patients with DN were included in the MAU and MaAU groups. Total cholesterol, triglyceride, low‐density lipoprotein cholesterol, glycosylated hemoglobin, fasting blood glucose, 2‐h postprandial blood glucose, blood urea nitrogen, serum creatinine, 24‐h urine microalbumin, IL‐8 and sTWEAK levels were measured. Logistic regression was used to analyze the factors associated with proteinuria.ResultsIn the healthy controls, normoalbuminuria, MAU and MaAU groups, we found that IL‐8 levels increased, whereas sTWEAK levels decreased (P < 0.05). IL‐8 might be an independent risk factor and serum sTWEAK a protective factor for MAU and MaAU. Serum levels of sTWEAK, IL‐8 and microalbumin were significantly correlated in the MAU and MaAU groups.ConclusionsSerum IL‐8 and sTWEAK levels might be markers that can be used for an early diagnosis of DN.

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Section: Discussionmentioning

confidence: 99%

Clinical significance of serum interleukin‐8 and soluble tumor necrosis factor‐like weak inducer of apoptosis levels in patients with diabetic nephropathy

Liu

Chen

2018

J of Diabetes Invest

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“…Other studies have used this information to identify associations between outcomes. One study reported that albuminuria may be a biomarker for hypertension and diabetes mellitus;8 another study reported serum uric acid to be positively associated with pulmonary function 9. Moreover, lifestyle factors have been shown to be associated with gastroesophageal reflux disease, and one study linked health screening and claims data to predict hospitalization due to pneumonia 1011.…”

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confidence: 99%

The Multi-Institutional Health Screening Records Database of South Korea: Description and Evaluation of Its Characteristics

et al. 2019

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This study sought to describe and to evaluate the characteristics of the Health Screening Records Database (HSRD) of the Korea Association of Health Promotion as a data source for epidemiologic studies. The HSRD was compared to a National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) database for 2015. Common variables between the databases were selected, and sex-based analyses were conducted. The HSRD showed statistical concordance when NHIS-HEALS estimates fell within the HSRD estimate's 95% confidence interval. The HSRD and NHIS-HEALS included 946461 and 111690 participants in health screening programs, respectively. Compared to the NHIS-HEALS, the HSRD had more female (55.2% vs. 42.6%) but fewer older adult participants (34.4% vs. 51.2%). Virtually all variables had clinical concordance, with some having statistical concordance as well, among both general and life-transition program participants. The HSRD comprised more clinical information over a wider age range in contrast to the NHIS-HEALS, while showing clinical concordance. Providing more comprehensive clinical data, the HSRD may serve as an alternative resource for epidemiologic studies.

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Albuminuria is Suggested as a Potential Health Screening Biomarker for Senior Citizens and General Population with Hypertension or Diabetes in China

Abstract: Albuminuria should be suggested as a potential health screening biomarker in senior citizens and general population with hypertension and diabetes.

Cited by 2 publications

References 0 publications

Clinical significance of serum interleukin‐8 and soluble tumor necrosis factor‐like weak inducer of apoptosis levels in patients with diabetic nephropathy

Clinical significance of serum interleukin‐8 and soluble tumor necrosis factor‐like weak inducer of apoptosis levels in patients with diabetic nephropathy

The Multi-Institutional Health Screening Records Database of South Korea: Description and Evaluation of Its Characteristics

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