Alcea rosea root extract as a preventive and curative agent in ethylene glycol-induced urolithiasis in rats

Ahmadi, M. Amir; Rad, Abolfazl Khajavi; Rajaei, Ziba; Hadjzadeh, Mousa‐Al‐Reza; Mohammadian, N Doust; Tabasi, Nafiseh

doi:10.4103/0253-7613.96298

Cited by 25 publications

(11 citation statements)

References 19 publications

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“…[ 91 ], Tribulus terrestris L. [ 92 ], Acalypha indica L. [ 93 ], Aerva lanata (L.) Juss. [ 94 ], Ageratum conyzoides (L.) L. [ 11 ], Alcea rosea L. [ 95 ], Asparagus racemosus Willd. [ 96 ], Bombax ceiba L. [ 97 ], Carthamus tinctorius L. [ 98 ], Cynodon dactylon (L.) Pers.…”

Section: Medicinal Plants and Phytoconstituents As Dietary Supplemmentioning

confidence: 99%

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Nirumand

Hajialyani

Rahimi

et al. 2018

IJMS

174

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Kidney stones are one of the oldest known and common diseases in the urinary tract system. Various human studies have suggested that diets with a higher intake of vegetables and fruits play a role in the prevention of kidney stones. In this review, we have provided an overview of these dietary plants, their main chemical constituents, and their possible mechanisms of action. Camellia sinensis (green tea), Rubus idaeus (raspberry), Rubia cordifolia (common madder), Petroselinum crispum (parsley), Punica granatum (pomegranate), Pistacia lentiscus (mastic), Solanum xanthocarpum (yellow-fruit nightshade), Urtica dioica (stinging nettle), Dolichos biflorus (horse gram), Ammi visnaga (khella), Nigella sativa (black-cumin), Hibiscus sabdariffa (roselle), and Origanum vulgare (oregano) have received considerable interest based on scientific evidence. Beside these dietary plants, phytochemicals—such as catechin, epicatechin, epigallocatechin-3-gallate, diosmin, rutin, quercetin, hyperoside, and curcumin—as antioxidant dietary phyto-phenols were found to be effective for the prevention of urolithiasis (the process of stone formation in the urinary tract). The main underlying mechanisms of these dietary plants and their isolated phytonutrients in the management of urolithiasis include diuretic, antispasmodic, and antioxidant activity, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The results as presented in this review demonstrate the promising role of dietary plants and phytophenols in the prevention and management of kidney stones. Further investigations are required to confirm the safety and efficacy of these compounds.

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Section: Medicinal Plants and Phytoconstituents As Dietary Supplemmentioning

confidence: 99%

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Nirumand

Hajialyani

Rahimi

et al. 2018

IJMS

174

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“… 2016 ), antiurolithiatic, diuretic anti-inflammatory (Ahmadi et al. 2012 ), antibacterial (Lim 2014 ), hepatoprotective (Hussain et al. 2014 ), analgesic and cytotoxic activities (Wang et al.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of hyperglycaemia and modulation of antioxidant status by Alcea rosea seeds in alloxan-induced diabetic rats

Dar

Ali

Sheikh

et al. 2017

Pharmaceutical Biology

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Context:Alcea rosea L. (Malvaceae) has various medicinal uses including anticancer, anti-inflammatory and analgesic properties. However, there is no report on its antidiabetic activity.Objective:Alcea rosea seed extracts were evaluated for antihyperglycaemic and antioxidative potential in diabetic rats.Materials and methods: Single intra-peritoneal injection of alloxan (130 mg/kg b.w.) was used for induction of diabetes in Albino Wistar rats. Antihyperglycaemic and antioxidant activities of methanol and aqueous extracts of Alcea rosea seed (100 and 300 mg/kg b.w.), administered orally on daily basis for 15 days, were assessed in vivo for fasting blood glucose level and antioxidant status of liver and pancreas. Metformin was used as a positive control.Results: Aqueous and methanol extracts (300 mg/kg b.w.) decreased blood glucose level in diabetic rats by 24% and 46%, respectively. Administration of aqueous and methanol extracts at 300 mg/kg b.w. significantly (p < 0.01) modulated the antioxidant status of liver in diabetic rats by increasing levels of GR (22.5 ± 1.0, 24.4 ± 1.02 μg GSSG utilized/min/mg of protein), GPx (20.7 ± 1.2, 23.6 ± 2.04 μg GSH utilized/min/mg of protein), SOD (36.1 ± 1.7, 39.05 ± 1.5 units/mg of protein) and CAT (1744.5 ± 132.5, 1956.6 ± 125.2 nmol H2O2 decomposed/min/mg of protein), respectively. Similar results were observed for pancreas.Discussion and conclusions: Antihyperglycaemic and antioxidative potentials of Alcea rosea seeds suggest its usefulness in management of diabetes and its complications. This is the first report on antidiabetic activity of this plant.

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“…showed that hydroalcoholic extract of Alcearosea had both preventive and curative effects on the formation of CaOx calculi apparently due to its diuretic and anti-inflammatory activities, presence of mucilaginous polysaccharides, and lowering of urinary concentrations of stone-forming constituents. [ 23 ] Low volume of urine is one the risk factors of nephrolithiasis due to hypersaturation of all solutes. [ 23 24 ] It has been reported that A. millefolium has diuretic effects and increases diuresis by 25% from initial volume without changing of urine pH in the patients with calcium type of urolithiasis.…”

Section: Discussionmentioning

confidence: 99%

“…[ 23 ] Low volume of urine is one the risk factors of nephrolithiasis due to hypersaturation of all solutes. [ 23 24 ] It has been reported that A. millefolium has diuretic effects and increases diuresis by 25% from initial volume without changing of urine pH in the patients with calcium type of urolithiasis. [ 24 ] Therefore, the diuretic effect of A. millefolium may be another possible mechanism involved in prevention of new calculi formation and dissolution of preformed stones.…”

Section: Discussionmentioning

confidence: 99%

Biochemical and pathological study of hydroalcoholic extract of Achillea millefolium l. on ethylene glycol-induced nephrolithiasis in laboratory rats

et al. 2014

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Background:Nephrolithiasis is of the most prevalent urinary tract disease. It seems worthwhile to replace the conventional treatments with more beneficial and safer agents, particularly herbal medicines which are receiving an increasing interest nowadays.Aims:In this study, we investigated the protective and curative effects of Achillea millefolium L. on ethylene glycol (EG)-induced nephrolithiasis in rats.Materials and Methods:The extract of A. millefolium was prepared by soxhlet method. Forty male Wistar rats were randomly divided into five groups (N = 8) as follows. The negative control (group A) received tap drinking water. Rats in sham (positive control group B), curative (group C and D), and preventive (group E) groups all received 1% EG in drinking water according to the experimental protocol for 30 days. In the curative groups, dosages of 200 and 400 mg/kg body weight (BW) of A. millefolium extract were administered orally from day 15 to the end of the experiment, group C and D, respectively. Group E received 200 mg/kg A. millefolium extract from the 1st day throughout the experiment. Urinary oxalate and citrate concentrations were measured by spectrophotometer on the first and 30th days. On day 31, the kidneys were removed and examined histopathologically for counting the calcium oxalate (CaOx) deposits in 50 microscopic fields.Results:In the curative and preventive groups, administration of A. millefolium extract showed significant reduction in urinary oxalate concentration (P < 0.05). Also, urinary citrate concentration was significantly increased in group C, D, and E. The CaOx deposits significantly decreased in group C to E compared with the group B.Conclusions:According to our results, A. millefolium extract had preventive and curative effects on EG-induced renal calculi.

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Alcea rosea root extract as a preventive and curative agent in ethylene glycol-induced urolithiasis in rats

Cited by 25 publications

References 19 publications

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms

Amelioration of hyperglycaemia and modulation of antioxidant status by Alcea rosea seeds in alloxan-induced diabetic rats

Biochemical and pathological study of hydroalcoholic extract of Achillea millefolium l. on ethylene glycol-induced nephrolithiasis in laboratory rats

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