Alcohol Affects the Late Differentiation of Progenitor B Cells

Wang, Hao; Zhou, Huijuan; Mahler, Simon A.; Chervenak, Robert; Wolcott, Michael P.

doi:10.1093/alcalc/agq076

Cited by 20 publications

(16 citation statements)

References 45 publications

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“…; Wang et al . ). However, to date, there are no studies about specific effects on different microflora components.…”

Section: Resultsmentioning

confidence: 97%

“…The consumption of these stimulants, over a period of one or more decades has been shown to affect the integrity of the oral cavity and the local immune system (Malhotra et al 2010;Wang et al 2011). However, to date, there are no studies about specific effects on different microflora components.…”

Section: Oral Microbiota Is Modulated In a Species-specific Manner Bymentioning

confidence: 99%

“…In addition to their stimulant effects upon the central nervous system, both substances contribute highly to the risk of developing oral cancer (Hashibe et al 2000;Johnson 2001). The effects of alcohol on the human immune system include the impairment of B cell differentiation, abnormalities in the function and structure of lymphocytes, Kupffer cells and other macrophages, and the impairment of cellular immunity (Watson et al 1994;Szabo 1999;Wang et al 2011).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alcohol and tobacco consumption affect the oral carriage ofCandida albicansand mutans streptococci

Sheth

Makda

Dilmahomed

et al. 2016

Lett Appl Microbiol

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In this paper, we evaluate the effect of alcohol and tobacco consumption on key species of the oral microflora. Our results show species-specific changes in two major opportunistic pathogens, such as Candida albicans and mutans streptococci, whereas other members of oral microflora are not affected by the consumption of the stimulants studied. We believe this original paper will contribute to raise awareness among the dental community towards a more personalized oral health assessment, taking in consideration alcohol and tobacco consumption in the prevention of specific oral and systemic pathologies.

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“…; Wang et al . ). However, to date, there are no studies about specific effects on different microflora components.…”

Section: Resultsmentioning

confidence: 97%

Section: Oral Microbiota Is Modulated In a Species-specific Manner Bymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alcohol and tobacco consumption affect the oral carriage ofCandida albicansand mutans streptococci

Sheth

Makda

Dilmahomed

et al. 2016

Lett Appl Microbiol

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“…Some reports have found that EtOH consumption is associated with a lower production of B lymphocytes in the bone marrow (Chang et al, 2002;Wang et al, 2011), but this finding has not been confirmed by other groups (Cook et al, 2007;Zhang et al, 2012). In addition, excessive amounts of interleukin (IL) 4-a T helper (Th) 2 cytokine that prevails in ALD over the Th1 cytokines (Laso et al, 1999)-together with the inability of B cells to properly interact with IL-4, may also lead to an abnormally diminished B-cell expansion capacity, at least in patients with AH.…”

Section: Discussionmentioning

confidence: 99%

Altered Distribution of Peripheral Blood Maturation-Associated B-Cell Subsets in Chronic Alcoholism

Almeida

Polvorosa

Gonzalez-Quintela

et al. 2015

Alcohol Clin Exp Res

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“…48,62 (43,98) 45,38 (42,38) 46,81 (46,20-49,01) 43,09 (36,(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)29) р 0 = 0,032…”

Section: результаты и обсуждениеmentioning

confidence: 99%

Features of cellular immunity and regeneration for alcoholic fibrosis of the liver

et al. 2019

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Purpose. The subpopulation composition of peripheral blood lymphocytes was evaluated in patients with alcoholic liver fibrosis (ALF).Materials and methods. The study included 62 patients with ALF; 15 patients abusing alcohol without liver fibrosis and 20 conditionally healthy donors. In samples of lysed peripheral blood, the number of cells bearing surface markers was determined by flow cytometry. In patients with ALF at terminal stages of fibrosis, significant lymphopenia was recorded with a change in the composition of the main subpopulations of lymphocytes relative to the values of conditionally healthy donors and the comparison group.Results. We identified in the blood of ALF patients with terminal (III–IV) stage (relative to control and comparison group) of the relative number of naive (TN) and central memory T-lymphocytes (TCM) associated with an increase in the number of effector cells (TEM and TEMRA) allows us to suggest in this category of patients the direct differentiation of TN and TCM lymphocytes to effector (TEM and TEMRA), which can aggravate the course of the tissue-destructive process due to the high biocidal activity of the latter. Elevated levels of hematopoietic (CD34 and CD133) cells in the peripheral blood at the initial and moderate stages. (I–II) fibrosis (relative to control and comparison group) may be due to persistent inflammation in the liver parenchyma and an increasing imbalance between the processes of its damage and reparative capabilities. Whereas the decrease in their number at the terminal station fibrosis may indicate an increasing decompensation and depletion of the regenerative potential of the organism in the final stages of the degenerative process.Conclusions. In general, the obtained data demonstrate new aspects of the immune regulation of the processes of fibrogenesis in chronic alcoholism.

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Alcohol Affects the Late Differentiation of Progenitor B Cells

Abstract: Alcohol affects the ONP cell differentiation into B lineage at a late stage. Alcohol also down-regulates the expression level of TFs and cytokine receptors resulting in the impairment of B cell differentiation.

Cited by 20 publications

References 45 publications

Alcohol and tobacco consumption affect the oral carriage ofCandida albicansand mutans streptococci

Alcohol and tobacco consumption affect the oral carriage ofCandida albicansand mutans streptococci

Altered Distribution of Peripheral Blood Maturation-Associated B-Cell Subsets in Chronic Alcoholism

Features of cellular immunity and regeneration for alcoholic fibrosis of the liver

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