Alcohol, Aggression, and Violence: From Public Health to Neuroscience

Sontate, Kajol V.; Kamaluddin, Mohammad Rahim; Mohamed, Isa Naina; Mohamed, Rashidi Mohamed Pakri; Shaikh, Mohd Farooq; Kamal, Haziq; Kumar, Jaya

doi:10.3389/fpsyg.2021.699726

Cited by 66 publications

(28 citation statements)

References 187 publications

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“…Apart from stress models, escalated aggression can be induced in animal models of experimental alcohol addiction during withdrawal from prolonged exposure to repeated high alcohol doses, which is modelled in mice, rats and monkeys, or by acute alcohol exposure [ 85 ]. This model is of particular relevance, as in humans, aggression is heavily associated with use of alcohol [ 86 ] which also can further aggravate depression [ 87 , 88 ]. According to the World Health Organization, alcohol consumption is more strongly associated with aggressive behaviour than the use of any other psychotropic substance [ 89 ], with alcoholics being 2–3 times more likely to experience depressive symptoms than the average population [ 88 ].…”

Section: Animal Models Of Excessive Aggressionmentioning

confidence: 99%

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Gorlova

Svirin

Павлов

et al. 2023

IJMS

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Aggression and deficient cognitive control problems are widespread in psychiatric disorders, including major depressive disorder (MDD). These abnormalities are known to contribute significantly to the accompanying functional impairment and the global burden of disease. Progress in the development of targeted treatments of excessive aggression and accompanying symptoms has been limited, and there exists a major unmet need to develop more efficacious treatments for depressed patients. Due to the complex nature and the clinical heterogeneity of MDD and the lack of precise knowledge regarding its pathophysiology, effective management is challenging. Nonetheless, the aetiology and pathophysiology of MDD has been the subject of extensive research and there is a vast body of the latest literature that points to new mechanisms for this disorder. Here, we overview the key mechanisms, which include neuroinflammation, oxidative stress, insulin receptor signalling and abnormal myelination. We discuss the hypotheses that have been proposed to unify these processes, as many of these pathways are integrated for the neurobiology of MDD. We also describe the current translational approaches in modelling depression, including the recent advances in stress models of MDD, and emerging novel therapies, including novel approaches to management of excessive aggression, such as anti-diabetic drugs, antioxidant treatment and herbal compositions.

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Section: Animal Models Of Excessive Aggressionmentioning

confidence: 99%

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Gorlova

Svirin

Павлов

et al. 2023

IJMS

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“…People may also drink alcohol for enhancement (excitement) and to socialize (celebrate), cope, and conform (Kuntsche & Callinan, 2018 ). Whatever the drivers might be, of concern is the known associations between moderate and high levels of alcohol use and adverse health outcomes (Black, 2021 ; Lee & Walter, 2017 ), aggression, violence and domestic abuse (Sontate et al, 2021 ), and impaired driving (Canadian Centre on Substance Use and Addiction, 2021 a). Discovering one’s motivation to drink alcohol may help guide strategies to reduce harmful drinking behaviours.…”

Section: Discussionmentioning

confidence: 99%

Predictors of reported alcohol intake during the first and second waves of the COVID-19 pandemic in Canada among middle-aged and older adults: results from the Canadian Longitudinal Study on Aging (CLSA)

McMillan

Hogan

Zimmer

et al. 2022

Can J Public Health

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Objective To examine proportions and predictors of change in alcohol intake and binge drinking during the first 2 waves of the COVID-19 pandemic among middle-aged and older participants in the Canadian Longitudinal Study on Aging (CLSA) COVID-19 Questionnaire Study. Methods A total of 28,559 (67.2% of the potential sample) CLSA participants consented to the study with 24,114 completing the exit survey (fall 2020). Descriptive statistics and logistic regressions to examine predictors of change (increase or decrease) in alcohol intake and binge drinking were performed. Results Among alcohol users, 26.3% reported a change in alcohol consumption during the first 10 months of the pandemic. Similar percentages increased (13.0%) or decreased (13.3%) consumption. In our mutually adjusted logistic regression model, odds of change in alcohol intake were greater for younger age, higher income, current cannabis smoker, positive screen for depression, anxiety, and loneliness. The magnitude of all associations for decreased intake was less than that of increased intake, and the directions were opposite for male sex and age. Predictors of current binge drinking (27.9% of alcohol users) included male sex, younger age, higher education and income, cannabis use, depression, and anxiety. Conclusion Factors predictive of potentially worrisome alcohol use (i.e. increased intake, binge drinking) included younger age, sex, greater education and income, living alone, cannabis use, and worse mental health. Some of these factors were also associated with decreased intake, but the magnitudes of associations were smaller. This information may help direct screening efforts and interventions towards individuals at risk for problematic alcohol intake during the pandemic.

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“…It is further worth noting that alcohol use has been associated with increased aggression [ 24 – 27 ], and some alcohol-involved crashes may result from aggressive driving and speeding. While this explanation is quite than our hypothesis of alcohol-induced sedation, it still reflects plausible examples of crash causality that does not rely on impairment of driving related skills.…”

Section: Discussionmentioning

confidence: 99%

The prevalence of alcohol-involved crashes across high and low complexity road environments: Does knowing where drinking drivers crash help explain why they crash?

Johnson

2022

PLoS ONE

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Objective Alcohol use has been linked to impairment of cognitive and psychomotor driving skills, yet the extent to which skill impairment contributes to actual crashes is unknown. A reasonable assumption is that some driving situations have higher skill demands than others. We contend that intersections, the presence of other vehicles or moving objects, and work zones are examples of common situations with higher skill demands. Accordingly, if skill deficits are largely responsible for alcohol-involved crashes, crashes involving a drinking driver (versus only sober drivers) should be overrepresented in these driving situations. Method Publicly available FARS data from 2010 to 2017 were collected. Fatal crashes were coded as alcohol-involved (1+ driver with a blood alcohol concentration [BAC] ≥ .05 g/dl) or having no impaired driver (BACs = .000). Drug-positive crashes were excluded. Crashes were also coded as involving moving versus stationary objects, occurring at versus away from intersections, being multivehicle versus single vehicle, occurring at or away from work zones. Results Across multiple models, controlling for time of day and type of road, alcohol-involved crashes were significantly underrepresented in crashes at intersections, with moving objects, and other vehicles. Most strikingly, alcohol-involved crashes were 24 percentage points more likely to be with a stationary object than a moving object. Conclusions No evidence supported the idea that skill reductions are a primary contributor to alcohol-involved crashes. Alternative explanations and limitations are discussed.

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Alcohol, Aggression, and Violence: From Public Health to Neuroscience

Cited by 66 publications

References 187 publications

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Understanding the Role of Oxidative Stress, Neuroinflammation and Abnormal Myelination in Excessive Aggression Associated with Depression: Recent Input from Mechanistic Studies

Predictors of reported alcohol intake during the first and second waves of the COVID-19 pandemic in Canada among middle-aged and older adults: results from the Canadian Longitudinal Study on Aging (CLSA)

The prevalence of alcohol-involved crashes across high and low complexity road environments: Does knowing where drinking drivers crash help explain why they crash?

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