Alcohol-based natural deep eutectic solvents (NADES) as green solvents for extraction of mangostins from Garcinia mangostana pericarp

Krisanti, Elsa Anisa; Terahadi, F; Fauzia, Farah; Putri, Selly Harnesa

doi:10.1055/s-0035-1565787

Cited by 8 publications

(6 citation statements)

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“…Alternatively, natural deep eutectic solvents (NADES) have also been applied [12,[20][21][22][23][24][25][26] for this purpose. In general, many multicomponent liquid mixtures, such as NADES [27][28][29][30][31][32], ionic liquids [30,[33][34][35], and organic solvent mixtures [36][37][38] are considered as promising green solvents. Another reason for binary solvents research is the optimization of reactants concentrations and crystallization efficiency [39][40][41][42][43][44].…”

Section: Introductionmentioning

confidence: 99%

Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility

2021

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Solubility enhancement of poorly soluble active pharmaceutical ingredients is of crucial importance for drug development and processing. Extensive experimental screening is limited due to the vast number of potential solvent combinations. Hence, theoretical models can offer valuable hints for guiding experiments aimed at providing solubility data. In this paper, we explore the possibility of applying quantum-chemistry-derived molecular descriptors, adequate for development of an ensemble of neural networks model (ENNM), for solubility computations of sulfamethizole (SMT) in neat and aqueous binary solvent mixtures. The machine learning procedure utilized information encoded in σ-potential profiles computed using the COSMO-RS approach. The resulting nonlinear model is accurate in backcomputing SMT solubility and allowed for extensive screening of green solvents. Since the experimental characteristics of SMT solubility are limited, the data pool was extended by new solubility measurements in water, five neat organic solvents (acetonitrile, N,N-dimethylformamide, dimethyl sulfoxide, 1,4-dioxane, and methanol), and their aqueous binary mixtures at 298.15, 303.15, 308.15, and 313.15 K. Experimentally determined order of decreasing SMT solubility in neat solvents is the following: N,N-dimethylformamide > dimethyl sulfoxide > methanol > acetonitrile > 1,4dioxane >> water, in all studied temperatures. Similar trends are observed for aqueous binary mixtures. Since N,N-dimethylformamide is not considered as a green solvent, the more acceptable replacers were searched for using the developed model. This step led to the conclusion that 4-formylmorpholine is a real alternative to N,N-dimethylformamide, fulfilling all requirements of both high dissolution potential and environmental friendliness.

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Section: Introductionmentioning

confidence: 99%

Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility

2021

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“…The absorption peak at 3160 cm –1 refers to the stretching vibrations of the OH group after the formation of a eutectic solvent. The NH group vibration of choline chloride is also at 3200 cm –1 . The vibrations of CH groups are seen at around 2900 cm –1 .…”

Section: Resultsmentioning

confidence: 90%

Liquid−Liquid Equilibrium Data for 1-Butanol–Methylcyclohexane and Acetonitrile–Benzene Mixtures Using Multiple Deep Eutectic Solvents Based on Choline Chloride

Tarighati,

Naderifar,

Pazuki

2024

J. Chem. Eng. Data

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Choline chloride (ChCl)-based deep eutectic solvents (DESs) have been utilized as a green extracting agent for the efficient extraction of 1-butanol from methylcyclohexane + butanol combinations and acetonitrile from benzene + acetonitrile mixture at atmospheric pressure and 298.15 K. The prepared DESs were ChCl + urea (DES1; 1:2 molar ratio), ChCl + 1,2-propanediol (DES2; 1:3 molar ratio), ChCl + ethylene glycol (DES3; 1:2 molar ratio), and ChCl + glycerol (DES4; 1:2 molar ratio). The Hand and Othmer−Tobias equations were used to evaluate the tie-line compositions' reliability. The extrication abilities of the examined DESs to separate methylcyclohexane +1-butanol and benzene + acetonitrile mixtures were compared to the NRTL model. The binary interaction parameters were established when the NRTL model corroborated the measured equilibrium data. The Gibbs topological analysis was utilized to validate consistency of the model parameters. The extraction equilibrium data showed that the selectivity parameter was higher than unity (S > 1) in all the evaluated systems. The distribution coefficient factor in systems containing ChCl−urea was higher than unity, indicating the need for smaller amounts of solvents to separate 1-butanol from methylcyclohexane, and the number of extraction steps was reduced. The distribution coefficient factor was less than unity in all systems, and more DESs were needed for optimal separation of acetonitrile from benzene.

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“…7 DESs have found an unquestionable role in extraction and separation processes, for example in the selective isolation and recovery of metals, 8 the isolation and recovery of compounds from natural products, 9 the desulfurization of fuels, 10 azeotrope breaking, 11 and water purification. 12,13 DESs represent a new generation of unconventional solvents which are obtained just by mixing two or more compounds, generally a salt and an amino acid, 14 a carbohydrate, 15 an alcohol, 16 a carboxylic acid 17 etc., which act as a hydrogen bond acceptor (HBA) and donor (HBD), respectively. This combination of a HBA and a HBD leads to the formation of a final liquid compound, with a melting point much lower than those of the individual starting components.…”

Section: Researcher Informationmentioning

confidence: 99%

Supramolecular hydrogel based on a sodium deep eutectic solvent

et al. 2018

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Alcohol-based natural deep eutectic solvents (NADES) as green solvents for extraction of mangostins from Garcinia mangostana pericarp

Cited by 8 publications

References 0 publications

Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility

Experimental and Theoretical Screening for Green Solvents Improving Sulfamethizole Solubility

Liquid−Liquid Equilibrium Data for 1-Butanol–Methylcyclohexane and Acetonitrile–Benzene Mixtures Using Multiple Deep Eutectic Solvents Based on Choline Chloride

Supramolecular hydrogel based on a sodium deep eutectic solvent

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