Alcohol consumption and digestive tract cancer

Haas, Stephan; Ye, Weimin; Löhr, Matthias

doi:10.1097/mco.0b013e3283566699

Cited by 66 publications

(49 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When alcohol is consumed, it is metabolized by alcohol dehydrogenases (ADH) and cytochrome P450 subenzyme 2E1 (CYP2E1), which catalyze the oxidation of alcohol to acetaldehyde [10]. Alcohol dehydrogenases ( ADH ) are a well-defined group of enzymes involved in general detoxification of alcohols and are associated with several human cancers, including CRC [11].…”

Section: Introductionmentioning

confidence: 99%

Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells

Moon

Lee

et al. 2014

BMC Cancer

View full text Add to dashboard Cite

BackgroundThe hypermethylation of Alcohol dehydrogenase iron containing 1 (ADHFE1) was recently reported to be associated with colorectal cancer (CRC) differentiation. However, the effect of alcohol on ADHFE1 hypermethylation in CRC is still unclear.MethodsThe methylation status and expression levels of ADHFE1 were investigated in primary tumor tissues and adjacent normal tissues of 73 patients with CRC, one normal colon cell line, and 4 CRC cell lines (HT-29, SW480, DLD-1, and LoVo) by quantitative methylation-specific polymerase chain reaction (QMSP) and real-time reverse transcription polymerase chain reaction (real time PCR), respectively. The effect of alcohol on the methylation status of ADHFE1 was analyzed in HT-29, SW480, DLD-1, and CCD18Co cells using QMSP, real-time PCR, immunoblot, and cell proliferation assay.ResultsADHFE1 was hypermethylated in 69 of 73 CRC tissues (95%) compared to adjacent normal tissues (p < 0.05). The mRNA expression of ADHFE1 was significantly reduced in CRC compared to adjacent normal tissues (p < 0.05) and its expression was decreased in the alcohol consumption group (p < 0.05). ADHFE1 was hypermethylated and its expression was decreased in 4 CRC cell lines compared with normal colon cell line. Alcohol induced hypermethylation of ADHFE1, decreased its expression, and stimulated cell proliferation of HT-29, SW480, and DLD-1cells.ConclusionThese results demonstrate that the promoter hypermethylation of ADHFE1 is frequently present in CRC and alcohol induces methylation-mediated down expression of ADHFE1 and proliferation of CRC cells.

show abstract

Section: Introductionmentioning

confidence: 99%

Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells

Moon

Lee

et al. 2014

BMC Cancer

View full text Add to dashboard Cite

show abstract

“…Probable mechanisms for the association between alcohol drinking and upper digestive tract cancer have been presented in several studies [98,99] . The carcinogen of esophageal cancer, with regard to alcohol consumption, is acetaldehyde [100,101] , which is a highly reactive and toxic alcohol metabolite.…”

Section: Oncogenic Effectsmentioning

confidence: 99%

Binge drinking: Burden of liver disease and beyond

Llerena¹

2015

WJH

View full text Add to dashboard Cite

binge drinking has generalized. It is considered to be a socio-sanitary problem with few known consequences in terms of individual and third-party social impacts (in the form of violence or traffic accidents) and its organic impact (affects the liver and other organs and systems, such as the nervous and cardiovascular systems) and represents an important financial burden due to its increasing economic impact. This review provides a global approach to binge drinking and emphasizes its epidemiological character, the effect of this type of consumption and the possible management of a problem with an increasing tendency in our society. Core tip: Binge drinking is an alcohol consumption conduct that is primarily performed during the weekend by 24% of teenagers and young adults. Although the consequences of this habit are not well known, they have a social and organic impact on individuals. Binge drinking is considered to be a public health issue that should be addressed with primary prevention programs and a comprehensive intervention of the problem. Author contributions: Llerena S, Arias-Loste MT, Puente A, Cabezas J, Crespo J and Fábrega E contributed equally to this work; Llerena S and Fábrega E wrote the paper. Conflict-of-interest statement:The authors of the present manuscript declare no conflict of interests. AbstractThe consumption of alcoholic beverages is harmful to human health. In recent years, consumption patterns of alcoholic beverages have changed in our society, and

show abstract

“…Submukozal fibrozis ağız içi mukozada sarımsı-beyaz renk değişimi şeklinde kendini gösterir. Sıklıkla tütün çiğneme alışkanlığının olduğu Asya'da görülür [2][3][4] . Oral mukozaya yerleşen HPV'nün kadınlarda serviks kanseri gelişimindeki gibi oral karsinogenezde de rol oynadığı bazı çalışmalarda gösterilmiştir.…”

Section: Etyopatogenezunclassified

Oral Mukozanın Malign Hastalıkları

...

2012

Turkderm

View full text Add to dashboard Cite

ÖzetDünyada önemli bir sağlık sorunu olan oral kanser, baş ve boyun kanserlerinin bir alt tipidir. Bu kanserler dünya çapında 6. en sık rastlanan malign tümörlerdir. Ağızdaki tüm malign tümörlerin % 90'ı skuamöz hücreli karsinomdur. Oral skuamöz hücreli karsinomun etyolojisi karmaşıktır. Özellikle gelişmiş ülkelerde en önemli risk faktörleri, sigara ve alkol alımıdır. (Türk derm 2012; 46 Özel Sayı 2: 90-5) Anah tar Ke li me ler: Oral mukoza, oral kanser, skuamöz hücreli karsinom Sum maryOral cancer which is a significant world health problem is a subtype of head and neck cancer. They are the sixth most common malignant tumors worldwide. More than 90% of malignant tumors in the mouth are squamous cell carcinomas. Etiology of the oral squamous cell carcinoma is complex. The most important risk factors, especially in well-developed countries are tobacco smoking and alcohol exposure.. Gi riflOral mukozada gelişen malignitelerin %90'dan fazlasının skuamöz hücreli karsinom (SHK) olduğu belirtilmiştir. Bunun %30'a yakını dudakları etkiler. Ağız içi ve dildeki yerleşim, temas edilen maddelere göre değişiklik gösterir. Ağız içi kanserlerinin çoğunluğu ağız tabanına yerleşse de, yanak mukoza yerleşimi de temasa bağlı olarak sıklıkla bildirilmiştir. Skuamöz Hücreli Karsinom SıklıkOral malignite gelişiminin Hindistan, Fransa, Güney Afrika, Brezilya ve Avustralya gibi ülkelerde sıklıkla arttığı bildirilmiştir 1 . Ülkemizde oral malignite sıklığı ile ilgili bir veri bulunmamakla beraber, dudak mukozası da düşünüldüğünde görülme sıklığının artmakta olduğu söylenebilir. Birinci derece akrabalarında oral SHK görülen kişilerde SHK gelişme sıklığı artmaktadır. EtyopatogenezHastalık etyopatogenezinde ultraviyole radyasyonu (genelde alt dudağı etkiler), sigara, tütün, "betel" (benzopren, nitrozamin) çiğnenmesi, ayrıca oral HPV infeksiyonu, kronik alkol tüketimi, meyve ve sebzelerden fakir diyet, ağız içi hijyen bozukluğu ve diş protezleri risk faktörleridir 1 . Lökoplaki ve eritroplaki gibi oral mukozaya yerleşen bazı premalign hastalıkların SHK gelişme riskini arttırdığı bilinmektedir 1,2 . Bunların dışında oral liken planus, diskoid lupus eritematozus ve submukozal fibrozis riski arttıran hastalıklardır. Farklı çalışmalarda, immün süpresif hastalarda oral SHK sıklığının özellikle gençlerde arttığı gözlenmiştir. Lökoplaki, oral mukozanın en sık rastlanan premalign lezyonu olup, 50 yaş üstü erkeklerde daha sık rastlanır 1,3 . Eritroplaki, lökoplakiden daha az sıklıkta görülmesine rağmen malignite gelişme riski daha fazladır. Oral liken planusun genelde erozif ve ülseratif tiplerinde malign dönüşüm görülebilir (Resim 1). Bu hastalarda oral hijyen bozukluğu, dental işlemler, gıdalar ve sigara kullanımı gibi

show abstract

Alcohol consumption and digestive tract cancer

Abstract: Alcohol overconsumption is a serious avoidable risk factor for the development of gastrointestinal tract cancer, both alone but even more in combination with other risk factors such as tobacco and obesity.

Cited by 66 publications

References 65 publications

Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells

Alcohol induces cell proliferation via hypermethylation of ADHFE1 in colorectal cancer cells

Binge drinking: Burden of liver disease and beyond

Oral Mukozanın Malign Hastalıkları

Contact Info

Product

Resources

About